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Metabolism of flavonolignans in human hepatocytes.
Vrba J, Papoušková B, Roubalová L, Zatloukalová M, Biedermann D, Křen V, Valentová K, Ulrichová J, Vacek J. Vrba J, et al. Among authors: papouskova b. J Pharm Biomed Anal. 2018 Apr 15;152:94-101. doi: 10.1016/j.jpba.2018.01.048. Epub 2018 Jan 31. J Pharm Biomed Anal. 2018. PMID: 29414024
This study examined the in vitro biotransformation of eight structurally related flavonolignans, namely silybin, 2,3-dehydrosilybin, silychristin, 2,3-dehydrosilychristin, silydianin, 2,3-dehydrosilydianin, isosilybin A and isosilybin B. The metabolic transformations were …
This study examined the in vitro biotransformation of eight structurally related flavonolignans, namely silybin, 2,3-dehydrosilybin, silychr …
Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases.
Vrba J, Papoušková B, Lněničková K, Kosina P, Křen V, Ulrichová J. Vrba J, et al. Among authors: papouskova b. Antioxidants (Basel). 2021 Jun 14;10(6):954. doi: 10.3390/antiox10060954. Antioxidants (Basel). 2021. PMID: 34198653 Free PMC article.
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively. ...Furthermore, we found that recombinant human UGTs 1A1, 1A3, 1A7, 1A8, 1A9, and 1A10 were capable o …
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin …
Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.
Vrba J, Papoušková B, Lněničková K, Kosina P, Křen V, Ulrichová J. Vrba J, et al. Among authors: papouskova b. J Pharm Biomed Anal. 2020 Jan 30;178:112972. doi: 10.1016/j.jpba.2019.112972. Epub 2019 Nov 4. J Pharm Biomed Anal. 2020. PMID: 31727359
This study was designed to identify UDP-glucuronosyltransferases (UGTs) involved in the glucuronidation of six silymarin flavonolignans, namely silybin A, silybin B, isosilybin A, isosilybin B, silychristin, and silydianin. UHPLC-MS analyses showed that all of the t …
This study was designed to identify UDP-glucuronosyltransferases (UGTs) involved in the glucuronidation of six silymarin flavonolignans, nam …
Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin.
Vrba J, Papoušková B, Kosina P, Lněničková K, Valentová K, Ulrichová J. Vrba J, et al. Among authors: papouskova b. Metabolites. 2020 Aug 12;10(8):329. doi: 10.3390/metabo10080329. Metabolites. 2020. PMID: 32806559 Free PMC article.
The study focused on major flavonolignan constituents, including silybin A, silybin B, isosilybin A, isosilybin B, silychristin, and silydianin, as well as the flavonoid taxifolin. ...The sulfation products detected were monosulfates, of which some of the major ones …
The study focused on major flavonolignan constituents, including silybin A, silybin B, isosilybin A, isosilybin B, silychristi …
Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo-controlled double-blind randomized clinical trial with cannabidiol.
Jirasek P, Jusku A, Frankova J, Urbankova M, Diabelko D, Ruzicka F, Papouskova B, Chytilova K, Vrba J, Havlasek J, Langova K, Storch J, Voborna I, Simanek V, Vacek J. Jirasek P, et al. Among authors: papouskova b. J Periodontal Res. 2024 Feb 5. doi: 10.1111/jre.13234. Online ahead of print. J Periodontal Res. 2024. PMID: 38311974
In the clinical part, a placebo-control double-blind randomized study was conducted (56 days) in three groups (n = 90) using dental gel without CBD (group A) and with 1% (w/w) CBD (group B) and corresponding toothpaste (group A - no CBD, group B - with CBD) for home …
In the clinical part, a placebo-control double-blind randomized study was conducted (56 days) in three groups (n = 90) using dental gel with …
The δ subunit of RNA polymerase is required for rapid changes in gene expression and competitive fitness of the cell.
Rabatinová A, Šanderová H, Jirát Matějčková J, Korelusová J, Sojka L, Barvík I, Papoušková V, Sklenár V, Žídek L, Krásný L. Rabatinová A, et al. Among authors: papouskova v. J Bacteriol. 2013 Jun;195(11):2603-11. doi: 10.1128/JB.00188-13. Epub 2013 Mar 29. J Bacteriol. 2013. PMID: 23543716 Free PMC article.
Finally, we show that two other proteins, GreA and YdeB, previously implicated to affect regulation of RNAP by [iNTP] in other organisms, do not have this function in B. subtilis....
Finally, we show that two other proteins, GreA and YdeB, previously implicated to affect regulation of RNAP by [iNTP] in other organisms, do …
Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry.
Kosina P, Vacek J, Papoušková B, Stiborová M, Stýskala J, Cankař P, Vrublová E, Vostálová J, Simánek V, Ulrichová J. Kosina P, et al. Among authors: papouskova b. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 1;879(15-16):1077-85. doi: 10.1016/j.jchromb.2011.03.023. Epub 2011 Mar 17. J Chromatogr B Analyt Technol Biomed Life Sci. 2011. PMID: 21482205
Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry.
Vacek J, Papoušková B, Kosina P, Vrba J, Křen V, Ulrichová J. Vacek J, et al. Among authors: papouskova b. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:109-15. doi: 10.1016/j.jchromb.2012.05.009. Epub 2012 May 14. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22664057
11 results