High precision NOEs as a probe for low level conformers--a second conformation of strychnine

Chem Commun (Camb). 2011 Jan 28;47(4):1193-5. doi: 10.1039/c0cc04114a. Epub 2010 Nov 26.

Abstract

A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Strychnine / chemistry*

Substances

  • Strychnine