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160 results

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Page 1
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street.
White PJ, McGarrah RW, Herman MA, Bain JR, Shah SH, Newgard CB. White PJ, et al. Mol Metab. 2021 Oct;52:101261. doi: 10.1016/j.molmet.2021.101261. Epub 2021 May 24. Mol Metab. 2021. PMID: 34044180 Free PMC article. Review.
SCOPE OF REVIEW: More recently, human metabolomics and genetic studies have confirmed and expanded upon these observations, accompanied by a surge in preclinical studies that have identified mechanisms involved in the perturbation of amino acid homeostasis- how these events are c …
SCOPE OF REVIEW: More recently, human metabolomics and genetic studies have confirmed and expanded upon these observations, accompanied by a …
Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes.
Vanweert F, Schrauwen P, Phielix E. Vanweert F, et al. Nutr Diabetes. 2022 Aug 5;12(1):35. doi: 10.1038/s41387-022-00213-3. Nutr Diabetes. 2022. PMID: 35931683 Free PMC article. Review.
Several studies showed elevated plasma BCAA levels in humans with insulin resistance and patients with T2D, although the underlying reason is unknown. ...In this review, we discuss several hypothesized mechanistic links between BCAA catabolism and i …
Several studies showed elevated plasma BCAA levels in humans with insulin resistance and patients with T2D, although th …
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis.
Verkerke ARP, Wang D, Yoshida N, Taxin ZH, Shi X, Zheng S, Li Y, Auger C, Oikawa S, Yook JS, Granath-Panelo M, He W, Zhang GF, Matsushita M, Saito M, Gerszten RE, Mills EL, Banks AS, Ishihama Y, White PJ, McGarrah RW, Yoneshiro T, Kajimura S. Verkerke ARP, et al. Cell. 2024 May 9;187(10):2359-2374.e18. doi: 10.1016/j.cell.2024.03.030. Epub 2024 Apr 22. Cell. 2024. PMID: 38653240 Free PMC article.
However, human BAT is protective against type 2 diabetes, independent of body weight. The mechanism underlying this dissociation remains unclear. Here, we report that impaired mitochondrial catabolism of branched-chain amino acids (BCAAs) in BAT, by deleting …
However, human BAT is protective against type 2 diabetes, independent of body weight. The mechanism underlying this dis …
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
Nie C, He T, Zhang W, Zhang G, Ma X. Nie C, et al. Int J Mol Sci. 2018 Mar 23;19(4):954. doi: 10.3390/ijms19040954. Int J Mol Sci. 2018. PMID: 29570613 Free PMC article. Review.
Current evidence supports BCAAs and their derivatives as the potential biomarkers of diseases such as insulin resistance (IR), type 2 diabetes mellitus (T2DM), cancer, and cardiovascular diseases (CVDs). These diseases are closely associa …
Current evidence supports BCAAs and their derivatives as the potential biomarkers of diseases such as insulin resistance (IR), …
Branched-chain amino acids in metabolic signalling and insulin resistance.
Lynch CJ, Adams SH. Lynch CJ, et al. Nat Rev Endocrinol. 2014 Dec;10(12):723-36. doi: 10.1038/nrendo.2014.171. Epub 2014 Oct 7. Nat Rev Endocrinol. 2014. PMID: 25287287 Free PMC article. Review.
However, circulating levels of BCAAs tend to be increased in individuals with obesity and are associated with worse metabolic health and future insulin resistance or type 2 diabetes mellitus (T2DM). A hypothesized mechanism linking increa …
However, circulating levels of BCAAs tend to be increased in individuals with obesity and are associated with worse metabolic health and fut …
Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance.
Saad MJ, Santos A, Prada PO. Saad MJ, et al. Physiology (Bethesda). 2016 Jul;31(4):283-93. doi: 10.1152/physiol.00041.2015. Physiology (Bethesda). 2016. PMID: 27252163 Free article. Review.
Obesity and insulin resistance are the major predisposing factors to comorbidities, such as Type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular and neurodegenerative diseases, and several types of cancer. ...In the near future, thi …
Obesity and insulin resistance are the major predisposing factors to comorbidities, such as Type 2 diabetes …
Advances in multi-omics study of biomarkers of glycolipid metabolism disorder.
Fang X, Miao R, Wei J, Wu H, Tian J. Fang X, et al. Comput Struct Biotechnol J. 2022 Oct 25;20:5935-5951. doi: 10.1016/j.csbj.2022.10.030. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36382190 Free PMC article. Review.
Several studies demonstrated that neuroendocrine axis dysfunction, insulin resistance, oxidative stress, chronic inflammatory response, and gut microbiota dysbiosis are core pathological links associated with it. ...
Several studies demonstrated that neuroendocrine axis dysfunction, insulin resistance, oxidative stress, chronic inflammatory …
Insulin resistance and cognitive decline: the metabolic mechanisms linking type 2 diabetes to Alzheimer's disease.
Majid H, Dahalia M, Hussain S, Saini S, Nidhi. Majid H, et al. Diabetol Int. 2025 Jul 1;16(4):614-629. doi: 10.1007/s13340-025-00830-0. eCollection 2025 Oct. Diabetol Int. 2025. PMID: 41111578 Free PMC article. Review.
BACKGROUND: Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) share overlapping pathophysiological pathways, including metabolic reprogramming, oxidative stress, and impaired cellular homeostasis. ...RESULTS: Overexpression of Branched Chain …
BACKGROUND: Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) share overlapping pathophysiological pa …
Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements.
Holeček M. Holeček M. Nutr Metab (Lond). 2018 May 3;15:33. doi: 10.1186/s12986-018-0271-1. eCollection 2018. Nutr Metab (Lond). 2018. PMID: 29755574 Free PMC article. Review.
Decreased BCKD activity is the main cause of increased BCAA levels and BCKAs in maple syrup urine disease, and plays a role in increased BCAA levels in diabetes type 2 and obesity. ...Further studies are needed to elucidate the effects of BCA …
Decreased BCKD activity is the main cause of increased BCAA levels and BCKAs in maple syrup urine disease, and plays a role in increa …
Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes.
Gao J, Re YanMu Rouzi M, Yang H, Zheng W, Wang L, Lei T, Lu J. Gao J, et al. Diabetol Metab Syndr. 2025 Aug 1;17(1):308. doi: 10.1186/s13098-025-01860-z. Diabetol Metab Syndr. 2025. PMID: 40751273 Free PMC article.
BACKGROUND: This study aimed to examine the association between branched-chain amino acids/branched-chain alpha-keto acids (BCAAs/BCKAs) and adipose tissue insulin resistance (Adipo-IR) in patients with type 2 diabetes mellitus (T2DM). ME …
BACKGROUND: This study aimed to examine the association between branched-chain amino acids/branched-chain alpha-keto acids (BCAAs/BCKAs) and …
160 results