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Did you mean bckd (137 results)?
BCKDK deficiency: a treatable neurodevelopmental disease amenable to newborn screening.
Tangeraas T, Constante JR, Backe PH, Oyarzábal A, Neugebauer J, Weinhold N, Boemer F, Debray FG, Ozturk-Hism B, Evren G, Tuba EF, Ummuhan O, Footitt E, Davison J, Martinez C, Bueno C, Machado I, Rodríguez-Pombo P, Al-Sannaa N, De Los Santos M, López JM, Ozturkmen-Akay H, Karaca M, Tekin M, Pajares S, Ormazabal A, Stoway SD, Artuch R, Dixon M, Mørkrid L, García-Cazorla A. Tangeraas T, et al. Brain. 2023 Jul 3;146(7):3003-3013. doi: 10.1093/brain/awad010. Brain. 2023. PMID: 36729635
Branched-chain ketoacid dehydrogenase kinase (BCKDK) deficiency causes branched-chain amino acid (BCAA) depletion and is linked to a neurodevelopmental disorder characterized by autism, intellectual disability and microcephaly. ...In this cross-sectional study, patients wi …
Branched-chain ketoacid dehydrogenase kinase (BCKDK) deficiency causes branched-chain amino acid (BCAA) depletion and is linked to a …
BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1.
Xu C, Yang K, Xuan Z, Li J, Liu Y, Zhao Y, Zheng Z, Bai Y, Shi Z, Shao C, Zhang L, Sun H. Xu C, et al. Cell Death Dis. 2023 Jul 17;14(7):445. doi: 10.1038/s41419-023-05944-4. Cell Death Dis. 2023. PMID: 37460470 Free PMC article.
However, the relevance of BCKDK to the development and progression of breast cancers and its function is unclear. This study found that BCKDK was overexpressed in breast cancer, associated with poor prognosis, and implicated in tumor metastasis. ...
However, the relevance of BCKDK to the development and progression of breast cancers and its function is unclear. This study found th …
BCKDK modification enhances the anticancer efficacy of CAR-T cells by reprogramming branched chain amino acid metabolism.
Yang Q, Zhu X, Huang P, Li C, Han L, Han Y, Gan R, Xin B, Tu Y, Zhou S, Yuan T, Hao J, Li C, Zhang L, Shi L, Guo C. Yang Q, et al. Mol Ther. 2024 Sep 4;32(9):3128-3144. doi: 10.1016/j.ymthe.2024.05.017. Epub 2024 May 11. Mol Ther. 2024. PMID: 38734897 Free PMC article.
BCKDK overexpression (OE) in CAR-T cells significantly improved cancer cell lysis, while BCKDK knockout (KO) resulted in inferior lysis potential. ...In conclusion, BCKDK-engineered CAR-T cells exert a distinct phenotype for superior anticancer efficiency....
BCKDK overexpression (OE) in CAR-T cells significantly improved cancer cell lysis, while BCKDK knockout (KO) resulted in infer …
Cross-talk between BCKDK-mediated phosphorylation and STUB1-dependent ubiquitination degradation of BCAT1 promotes GBM progression.
Wang W, Li Y, Tang L, Shi Y, Li W, Zou L, Zhang L, Cheng Y, Yuan Z, Zhu F, Duan Q. Wang W, et al. Cancer Lett. 2024 Jun 1;591:216849. doi: 10.1016/j.canlet.2024.216849. Epub 2024 Apr 16. Cancer Lett. 2024. PMID: 38621458 Free article.
We found that BCAT1 is phosphorylated by branched chain ketoacid dehydrogenase kinase (BCKDK) at S5, S9, and T312, which increases its catalytic and antioxidant activity and stability. ...In addition, we demonstrate through in vivo and in vitro experiments that BCAT1 phosp …
We found that BCAT1 is phosphorylated by branched chain ketoacid dehydrogenase kinase (BCKDK) at S5, S9, and T312, which increases it …
The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis.
Acevedo A, Jones AE, Danna BT, Turner R, Montales KP, Benincá C, Reue K, Shirihai OS, Stiles L, Wallace M, Wang Y, Bertholet AM, Divakaruni AS. Acevedo A, et al. J Biol Chem. 2024 Mar;300(3):105702. doi: 10.1016/j.jbc.2024.105702. Epub 2024 Jan 30. J Biol Chem. 2024. PMID: 38301896 Free PMC article.
The branched-chain ketoacid dehydrogenase kinase (BCKDK) inhibitor BT2 (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid) is often used in preclinical models to increase BCAA oxidation and restore steady-state BCAA and branched-chain alpha-ketoacid levels. BT2 administratio …
The branched-chain ketoacid dehydrogenase kinase (BCKDK) inhibitor BT2 (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid) is often use …
BCKDK alters the metabolism of non-small cell lung cancer.
Wang Y, Xiao J, Jiang W, Zuo D, Wang X, Jin Y, Qiao L, An H, Yang L, Dumoulin DW, Dempke WCM, Best SA, Ren L. Wang Y, et al. Transl Lung Cancer Res. 2021 Dec;10(12):4459-4476. doi: 10.21037/tlcr-21-885. Transl Lung Cancer Res. 2021. PMID: 35070754 Free PMC article.
Branched-chain alpha-keto acid dehydrogenase kinase (BCKDK) plays an important role in diabetes, obesity, and other diseases. However, the function of BCKDK in NSCLC is unclear. ...The expression of BCKDK was measured using reverse transcriptase-polymerase ch …
Branched-chain alpha-keto acid dehydrogenase kinase (BCKDK) plays an important role in diabetes, obesity, and other diseases. However …
BCKDK Promotes Ovarian Cancer Proliferation and Migration by Activating the MEK/ERK Signaling Pathway.
Li H, Yu D, Li L, Xiao J, Zhu Y, Liu Y, Mou L, Tian Y, Chen L, Zhu F, Duan Q, Xue P. Li H, et al. J Oncol. 2022 Apr 22;2022:3691635. doi: 10.1155/2022/3691635. eCollection 2022. J Oncol. 2022. PMID: 35498541 Free PMC article.
RESULTS: We found that the expression of BCKDK was upregulated in OC tissues and the high expression of BCKDK was correlated with an advanced pathological grade in patients. The ectopic overexpression of BCKDK promoted the proliferation and migration of OC ce …
RESULTS: We found that the expression of BCKDK was upregulated in OC tissues and the high expression of BCKDK was correlated w …
Bckdk-Mediated Branch Chain Amino Acid Metabolism Reprogramming Contributes to Muscle Atrophy during Cancer Cachexia.
Chen L, Zhang H, Chi M, Wang Y, Zhu X, Han L, Xin B, Gan R, Tu Y, Sun X, Lu J, Li J, Huang J, Zhang J, Han Y, Guo C, Yang Q. Chen L, et al. Mol Nutr Food Res. 2024 Jul;68(14):e2300577. doi: 10.1002/mnfr.202300577. Epub 2023 Dec 27. Mol Nutr Food Res. 2024. PMID: 38150655
The study uses muscle-specific branched-chain alpha-keto acid dehydrogenase kinase (Bckdk) conditional knockout (cKO) mice to reveal the contribution of BCAA metabolic dysfunction to muscle wasting. METHOD AND RESULTS: Muscle-specific Bckdk-cKO mice are generated th …
The study uses muscle-specific branched-chain alpha-keto acid dehydrogenase kinase (Bckdk) conditional knockout (cKO) mice to reveal …
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease.
Jishi A, Hu D, Shang Y, Wang R, Gunzler SA, Qi X. Jishi A, et al. Acta Neuropathol Commun. 2024 Dec 21;12(1):198. doi: 10.1186/s40478-024-01915-8. Acta Neuropathol Commun. 2024. PMID: 39709505 Free PMC article.
Mechanistically, BCKDK interacts with the NDUFS1 subunit of Complex I to stabilize its function. Loss of BCKDK disrupts this interaction, leading to Complex I destabilization and enhanced alphaSyn aggregation. ...Similarly, in patient-derived iPS cells differentiate …
Mechanistically, BCKDK interacts with the NDUFS1 subunit of Complex I to stabilize its function. Loss of BCKDK disrupts this i …
102 results