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1996 1
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105 results

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Page 1
BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARgamma/PDK1 dependent manner.
Wang Q, Liang N, Liu C, Li J, Bai Y, Lei S, Huang Q, Sun L, Tang L, Zeng C, Tang Y, He X, Yang T, Wang G. Wang Q, et al. Br J Cancer. 2023 Oct;129(9):1477-1489. doi: 10.1038/s41416-023-02418-4. Epub 2023 Sep 15. Br J Cancer. 2023. PMID: 37715024 Free PMC article.
RESULTS: Our results indicated that overexpression of BEX1 significantly enhanced the Warburg effect in HB cells. Furthermore, glycolysis inhibition largely attenuated the effects of BEX1 on HB cell growth and self-renewal, suggesting that BEX1 promotes stemn …
RESULTS: Our results indicated that overexpression of BEX1 significantly enhanced the Warburg effect in HB cells. Furthermore, glycol …
DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer.
Wang Q, Liang N, Yang T, Li Y, Li J, Huang Q, Wu C, Sun L, Zhou X, Cheng X, Zhao L, Wang G, Chen Z, He X, Liu C. Wang Q, et al. J Hepatol. 2021 Nov;75(5):1142-1153. doi: 10.1016/j.jhep.2021.06.025. Epub 2021 Jul 1. J Hepatol. 2021. PMID: 34217777
METHODS: Stemness scores were analyzed in 5 murine HCC models. A subpopulation of BEX1-positive cells and BEX1-negative cells were sorted from HCC cell lines, and subjected to transcriptome analysis. ...Moreover, DNMT1-mediated methylation of the BEX1 promote …
METHODS: Stemness scores were analyzed in 5 murine HCC models. A subpopulation of BEX1-positive cells and BEX1-negative cells …
BEX1 is a critical determinant of viral myocarditis.
Martens CR, Dorn LE, Kenney AD, Bansal SS, Yount JS, Accornero F. Martens CR, et al. PLoS Pathog. 2022 Feb 22;18(2):e1010342. doi: 10.1371/journal.ppat.1010342. eCollection 2022 Feb. PLoS Pathog. 2022. PMID: 35192678 Free PMC article.
Interestingly, despite the greater viral load observed in mice lacking BEX1, inflammatory immune cell recruitment in the mouse heart was profoundly impaired in the absence of BEX1. ...Conversely, transgenic mice overexpressing BEX1 in cardiomyocytes revealed …
Interestingly, despite the greater viral load observed in mice lacking BEX1, inflammatory immune cell recruitment in the mouse heart …
Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.
Hibino E, Ichiyama Y, Tsukamura A, Senju Y, Morimune T, Ohji M, Maruo Y, Nishimura M, Mori M. Hibino E, et al. BMC Biol. 2022 Feb 10;20(1):42. doi: 10.1186/s12915-022-01246-x. BMC Biol. 2022. PMID: 35144600 Free PMC article.
RESULTS: Here we show that brain expressed X-linked 1 (Bex1) plays an essential role in tubulin polymerization and primary cilia formation. The Bex1 protein shows the physicochemical property of being an intrinsically disordered protein (IDP). ...The apical Bex1 …
RESULTS: Here we show that brain expressed X-linked 1 (Bex1) plays an essential role in tubulin polymerization and primary cilia form …
BEX1 mediates sorafenib resistance in hepatocellular carcinoma by regulating AKT signaling.
Zhuang N, Gu Z, Feng J, Chai Z, Shan J, Qian C. Zhuang N, et al. Cell Signal. 2023 Aug;108:110722. doi: 10.1016/j.cellsig.2023.110722. Epub 2023 May 19. Cell Signal. 2023. PMID: 37209973
Loss- and gain-of-function studies showed that BEX1 regulates the cell-killing ability of sorafenib. Further studies revealed that BEX1 renders HCC cells sensitive to sorafenib via induction of apoptosis and negatively regulates the phosphorylation of Akt. In summar …
Loss- and gain-of-function studies showed that BEX1 regulates the cell-killing ability of sorafenib. Further studies revealed that …
BEX1 is an RNA-dependent mediator of cardiomyopathy.
Accornero F, Schips TG, Petrosino JM, Gu SQ, Kanisicak O, van Berlo JH, Molkentin JD. Accornero F, et al. Nat Commun. 2017 Nov 30;8(1):1875. doi: 10.1038/s41467-017-02005-1. Nat Commun. 2017. PMID: 29192139 Free PMC article.
Modeling the increase in BEX1 that occurs in disease, cardiac-specific BEX1 transgenic mice show worse cardiac disease with stress stimulation, whereas Bex1 gene-deleted mice are protected from heart failure-promoting insults. ...Thus, BEX1 functions a …
Modeling the increase in BEX1 that occurs in disease, cardiac-specific BEX1 transgenic mice show worse cardiac disease with st …
Bex1 attenuates neuronal apoptosis in rat intracerebral hemorrhage model.
He M, Wang Y, Shen J, Duan C, Lu X, Li J. He M, et al. Pathol Res Pract. 2018 Apr;214(4):527-535. doi: 10.1016/j.prp.2018.02.012. Epub 2018 Feb 21. Pathol Res Pract. 2018. PMID: 29572119
The in vitro study using Bex1 siRNA transfection in hemin-exposed PC12 cells suggested that Bex1 exerted anti-apoptotic function. Therefore, Bex1 may play the neuronal anti-apoptosis role following ICH, implying a novel molecular target for the therapy of ICH …
The in vitro study using Bex1 siRNA transfection in hemin-exposed PC12 cells suggested that Bex1 exerted anti-apoptotic functi …
BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2.
Xiao Q, Hu Y, Liu Y, Wang Z, Geng H, Hu L, Xu D, Wang K, Zheng L, Zheng S, Ding K. Xiao Q, et al. PLoS One. 2014 Mar 13;9(3):e91782. doi: 10.1371/journal.pone.0091782. eCollection 2014. PLoS One. 2014. PMID: 24626299 Free PMC article.
The interaction between BEX1 and BCL-2 was subsequently confirmed by co-immunoprecipitation assays. Like BCL-2, BEX1 was localized to the mitochondria. ...Our results revealed an interaction between BEX1 and BCL-2 and a novel mechanism of imatinib resistance …
The interaction between BEX1 and BCL-2 was subsequently confirmed by co-immunoprecipitation assays. Like BCL-2, BEX1 was local …
Bex1 knock out mice show altered skeletal muscle regeneration.
Koo JH, Smiley MA, Lovering RM, Margolis FL. Koo JH, et al. Biochem Biophys Res Commun. 2007 Nov 16;363(2):405-10. doi: 10.1016/j.bbrc.2007.08.186. Epub 2007 Sep 11. Biochem Biophys Res Commun. 2007. PMID: 17884015 Free PMC article.
To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1-KO) mice. ...Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to prop …
To study the role of Bex1 and its interaction with CaM in skeletal muscle regeneration, we generated Bex1 knock out (Bex1 …
105 results