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Year Number of Results
1972 1
1977 1
1983 1
1986 1
2000 1
2005 1
2008 1
2009 3
2010 2
2013 1
2014 1
2015 3
2016 2
2017 5
2018 1
2019 2
2020 2
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Reactivation of BK polyomavirus in patients with multiple sclerosis receiving natalizumab therapy.
Lonergan RM, Carr MJ, De Gascun CF, Costelloe LF, Waters A, Coughlan S, Duggan M, Doyle K, Jordan S, Hutchinson MW, Hall WW, Tubridy NJ. Lonergan RM, et al. J Neurovirol. 2009 Sep;15(5-6):351-9. doi: 10.3109/13550280903131923. J Neurovirol. 2009. PMID: 19670070
Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leucoencephalopathy. ...Patients with relapsing remitting multiple sclerosis treated with natalizumab were prospectively monitored …
Natalizumab therapy in multiple sclerosis has been associated with JC polyomavirus-induced progressive multifocal leuco …
Polyomaviruses.
Cook L. Cook L. Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.DMIH2-0010-2015. Microbiol Spectr. 2016. PMID: 27726799 Review.
The first two human polyomaviruses discovered, BKPyV and JCPyV, are the causative agents for transplant-related kidney disease, BK commonly and JC rarely. JC has also been strongly associated with the development of progressive multifocal leukoencephalopathy (PML), a rare …
The first two human polyomaviruses discovered, BKPyV and JCPyV, are the causative agents for transplant-related kidney disease, BK co …
Polyomavirus detection in multiple sclerosis patients under natalizumab therapy: Profile and frequency of urinary shedding.
Nali LH, Fink MC, do Olival GS, Moraes L, Callegaro D, Tilbery CP, Vidal JE, Sumita LM, de Oliveira AC, Romano CM. Nali LH, et al. J Med Virol. 2017 Mar;89(3):528-534. doi: 10.1002/jmv.24646. Epub 2016 Aug 9. J Med Virol. 2017. PMID: 27464945
Besides John Cunningham virus (JCV), BK polyomavirus might represent an additional concern for such patients since it can also infect CNS cells. ...Here, we investigated the profile shedding of JCV and BKV in multiple sclerosis (MS) patients dur …
Besides John Cunningham virus (JCV), BK polyomavirus might represent an additional concern for such patients since it c …
Optimizing JC and BK polyomavirus IgG testing for seroepidemiology and patient counseling.
Kardas P, Leboeuf C, Hirsch HH. Kardas P, et al. J Clin Virol. 2015 Oct;71:28-33. doi: 10.1016/j.jcv.2015.07.305. Epub 2015 Jul 29. J Clin Virol. 2015. PMID: 26370311
BACKGROUND: Polyomavirus JC (JCPyV) and BK (BKPyV) can cause significant diseases in immunocompromised patients including nephropathy, hemorrhagic cystitis, and leukoencephalopathy. Recently, JCPyV and BKPyV IgG have been explored as risk predictors in multiple …
BACKGROUND: Polyomavirus JC (JCPyV) and BK (BKPyV) can cause significant diseases in immunocompromised patients including neph …
BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection.
Martelli F, Wu Z, Delbue S, Weissbach FH, Giulioli MC, Ferrante P, Hirsch HH, Giannecchini S. Martelli F, et al. Viruses. 2018 Aug 30;10(9):466. doi: 10.3390/v10090466. Viruses. 2018. PMID: 30200237 Free PMC article.
We found that laboratory and clinical rr-NCCR-BKPyV-strains show higher replication rates but significantly lower microRNA levels than archetype virus intracellularly and in exosomes. ...To explore the potential relevance in humans, urine samples from 12 natalizumab-treate …
We found that laboratory and clinical rr-NCCR-BKPyV-strains show higher replication rates but significantly lower microRNA levels than arche …
Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS.
Largey F, Jelcic I, Sospedra M, Heesen C, Martin R, Jelcic I. Largey F, et al. Neurol Neuroimmunol Neuroinflamm. 2019 Sep 25;6(6):e621. doi: 10.1212/NXI.0000000000000621. Print 2019 Nov. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31554671 Free PMC article.
METHODS: We performed a longitudinal, observational study analyzing both serum and CSF samples collected before and during NAT treatment for antibodies against measles, rubella, mumps, influenza, entero, herpes, and polyoma viruses, including JC polyomavirus (JCV) and its …
METHODS: We performed a longitudinal, observational study analyzing both serum and CSF samples collected before and during NAT treatment for …
JCV detection in multiple sclerosis patients treated with natalizumab.
Sadiq SA, Puccio LM, Brydon EW. Sadiq SA, et al. J Neurol. 2010 Jun;257(6):954-8. doi: 10.1007/s00415-009-5444-4. Epub 2010 Jan 7. J Neurol. 2010. PMID: 20052484
We wanted to investigate whether serial plasma and cerebrospinal fluid (CSF) screening for polyomavirus would identify patients with laboratory evidence of viral infection prior to the development of clinical PML. Two hundred MS patients had pre-treatment CSF/plasma screen …
We wanted to investigate whether serial plasma and cerebrospinal fluid (CSF) screening for polyomavirus would identify patients with …
Specific antibodies reacting to JC polyomavirus capsid protein mimotopes in sera from multiple sclerosis and other neurological diseases-affected patients.
Mazzoni E, Bononi I, Pietrobon S, Torreggiani E, Rossini M, Pugliatti M, Casetta I, Castellazzi M, Granieri E, Guerra G, Martini F, Tognon M. Mazzoni E, et al. J Cell Physiol. 2020 Jul;235(7-8):5847-5855. doi: 10.1002/jcp.29533. Epub 2020 Feb 3. J Cell Physiol. 2020. PMID: 32012272
JC (JC polyomavirus [JCPyV]), BK (BKPyV), and simian virus 40 (SV40) neurotropic polyomavirus footprints have been detected in brain tissue specimens and samples from patients affected by different neurological diseases. ...Our study indicates that the …
JC (JC polyomavirus [JCPyV]), BK (BKPyV), and simian virus 40 (SV40) neurotropic polyomavirus footprints have be …
Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease.
Haley SA, Atwood WJ. Haley SA, et al. Annu Rev Virol. 2017 Sep 29;4(1):349-367. doi: 10.1146/annurev-virology-101416-041439. Epub 2017 Jun 21. Annu Rev Virol. 2017. PMID: 28637388 Review.
The virus was named JC virus after the initials of the patient. In that same year a second human polyomavirus was discovered in the urine of a kidney transplant patient and named BK virus. ...We review what is currently known about JC polyoma …
The virus was named JC virus after the initials of the patient. In that same year a second human polyomavirus was disco …
Natalizumab-associated progressive multifocal leukoencephalopathy in Germany.
Blankenbach K, Schwab N, Hofner B, Adams O, Keller-Stanislawski B, Warnke C. Blankenbach K, et al. Neurology. 2019 May 7;92(19):e2232-e2239. doi: 10.1212/WNL.0000000000007451. Epub 2019 Apr 5. Neurology. 2019. PMID: 30952796
OBJECTIVE: To evaluate characteristics relevant to diagnosis of JC polyomavirus-associated progressive multifocal leukoencephalopathy (PML), and PML risk stratification in a large national cohort of patients with multiple sclerosis during therapy with nataliz …
OBJECTIVE: To evaluate characteristics relevant to diagnosis of JC polyomavirus-associated progressive multifocal leukoencephalopathy …
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