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13,916 results

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Page 1
Essential biochemistry and physiology of (NT-pro)BNP.
Hall C. Hall C. Eur J Heart Fail. 2004 Mar 15;6(3):257-60. doi: 10.1016/j.ejheart.2003.12.015. Eur J Heart Fail. 2004. PMID: 14987573 Free article. Review.
Recently, cardiac fibroblasts have also been shown to produce BNP. Other neurohormones may stimulate cardiac BNP production in different cardiac cell types. ...While the plasma concentration of NT-proBNP and BNP is approximately equal in normal controls, NT-p …
Recently, cardiac fibroblasts have also been shown to produce BNP. Other neurohormones may stimulate cardiac BNP production in …
BNP protects against diabetic cardiomyopathy by promoting Opa1-mediated mitochondrial fusion via activating the PKG-STAT3 pathway.
Chang P, Zhang X, Zhang J, Wang J, Wang X, Li M, Wang R, Yu J, Fu F. Chang P, et al. Redox Biol. 2023 Jun;62:102702. doi: 10.1016/j.redox.2023.102702. Epub 2023 Apr 20. Redox Biol. 2023. PMID: 37116257 Free PMC article.
Diabetic cardiomyopathy (DCM) is often associated with increased BNP levels. This present research intends to explore the role of BNP in the development of DCM and the underlying mechanisms. ...PKG, a crucial signaling biomolecule in the BNP signaling pathway …
Diabetic cardiomyopathy (DCM) is often associated with increased BNP levels. This present research intends to explore the role of …
Potential pitfalls when interpreting plasma BNP levels in heart failure practice.
Nishikimi T, Nakagawa Y. Nishikimi T, et al. J Cardiol. 2021 Oct;78(4):269-274. doi: 10.1016/j.jjcc.2021.05.003. Epub 2021 Jun 2. J Cardiol. 2021. PMID: 34088563 Free article. Review.
However, recent studies have shown that considerable amount of uncleaved proBNP circulates in the blood. The commercially available BNP assay kits consist of two antibodies that sandwich the BNP molecule. Therefore, if proBNP is present, BNP assay kit cross-r …
However, recent studies have shown that considerable amount of uncleaved proBNP circulates in the blood. The commercially available BNP …
B-Type Natriuretic Peptide (BNP) Revisited-Is BNP Still a Biomarker for Heart Failure in the Angiotensin Receptor/Neprilysin Inhibitor Era?
Nishikimi T, Nakagawa Y. Nishikimi T, et al. Biology (Basel). 2022 Jul 9;11(7):1034. doi: 10.3390/biology11071034. Biology (Basel). 2022. PMID: 36101415 Free PMC article. Review.
Currently available BNP immunoassays react with both mature BNP and proBNP. Therefore, BNP measured with an immunoassay is mature BNP + proBNP. ...Later, ARNI reduces myocardial wall stress, and the resultant reduction in BNP production more tha …
Currently available BNP immunoassays react with both mature BNP and proBNP. Therefore, BNP measured with an immunoassay …
Mechanisms of renal hyporesponsiveness to BNP in heart failure.
Egom EE, Feridooni T, Hotchkiss A, Kruzliak P, Pasumarthi KB. Egom EE, et al. Can J Physiol Pharmacol. 2015 Jun;93(6):399-403. doi: 10.1139/cjpp-2014-0356. Epub 2015 Feb 26. Can J Physiol Pharmacol. 2015. PMID: 25881664 Review.
Despite the potential benefits of BNP, accumulating evidence suggests that simply increasing the amount of circulating BNP does not necessarily increase natriuresis in patients with heart failure (HF). Moreover, despite high BNP levels, natriuresis falls when …
Despite the potential benefits of BNP, accumulating evidence suggests that simply increasing the amount of circulating BNP doe …
BNP and a renal patient: emphasis on the unique characteristics of B-type natriuretic peptide in end-stage kidney disease.
Haapio M, Ronco C. Haapio M, et al. Contrib Nephrol. 2008;161:68-75. doi: 10.1159/000129756. Contrib Nephrol. 2008. PMID: 18451660 Review.
RESULTS: We review in detail the physiology and effects of BNP along with providing a thoughtful analysis of the limitations of BNP testing in patients with impaired kidney function. Additionally, the practicability of BNP in the management of renal patients …
RESULTS: We review in detail the physiology and effects of BNP along with providing a thoughtful analysis of the limitations of BN …
BNP-Response to Acute Heart Failure Treatment Identifies High-Risk Population.
Patel AN, Southern WN. Patel AN, et al. Heart Lung Circ. 2020 Mar;29(3):354-360. doi: 10.1016/j.hlc.2019.02.004. Epub 2019 Feb 26. Heart Lung Circ. 2020. PMID: 30904237
Patients were divided into two groups based on their pro-BNP response to treatment: (1) pro-BNP responsive to treatment (decrease by at least 30%) and (2) pro-BNP unresponsive to treatment (decrease by less than 30%). ...RESULTS: The total study population in …
Patients were divided into two groups based on their pro-BNP response to treatment: (1) pro-BNP responsive to treatment (decre …
Atrial and brain natriuretic peptides: Hormones secreted from the heart.
Nakagawa Y, Nishikimi T, Kuwahara K. Nakagawa Y, et al. Peptides. 2019 Jan;111:18-25. doi: 10.1016/j.peptides.2018.05.012. Epub 2018 May 31. Peptides. 2019. PMID: 29859763 Free article. Review.
ProANP and beta-ANP are minor forms in the circulation but are increased in patients with heart failure. The human BNP precursor proBNP is proteolytically processed to BNP(1-32) and N-terminal proBNP (NT-proBNP) within ventricular myocytes. ...Mature BNP, its …
ProANP and beta-ANP are minor forms in the circulation but are increased in patients with heart failure. The human BNP precursor proB …
BNP as a New Biomarker of Cardiac Thyroid Hormone Function.
Wang K, Ojamaa K, Samuels A, Gilani N, Zhang K, An S, Zhang Y, Tang YD, Askari B, Gerdes AM. Wang K, et al. Front Physiol. 2020 Jul 9;11:729. doi: 10.3389/fphys.2020.00729. eCollection 2020. Front Physiol. 2020. PMID: 32733267 Free PMC article.
RESULTS: Six days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free …
RESULTS: Six days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in …
Cutting Edge of Brain Natriuretic Peptide (BNP) Research - The Diversity of BNP Immunoreactivity and Its Clinical Relevance.
Kuwahara K, Nakagawa Y, Nishikimi T. Kuwahara K, et al. Circ J. 2018 Sep 25;82(10):2455-2461. doi: 10.1253/circj.CJ-18-0824. Epub 2018 Aug 21. Circ J. 2018. PMID: 30135320 Free article. Review.
Recently, the diversity of BNP molecular forms in the peripheral circulation, which includes mature BNP (BNP(1-32)) and its metabolites (BNP(3-32), BNP(4-32), and BNP(5-32)), was demonstrated. ...Interestingly, BNP(1-32), its metab …
Recently, the diversity of BNP molecular forms in the peripheral circulation, which includes mature BNP (BNP(1-32)) and …
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