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26 results

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Page 1
BPIFB1 promotes metastasis of hormone receptor-positive breast cancer via inducing macrophage M2-like polarization.
Hu A, Liu Y, Zhang H, Wang T, Zhang J, Cheng W, Yu T, Duan Y, Feng J, Chen Z, Ding Y, Li Y, Li M, Rong Z, Shang Y, Shakila SS, Zou Y, Ma F, Guo B. Hu A, et al. Cancer Sci. 2023 Nov;114(11):4157-4171. doi: 10.1111/cas.15957. Epub 2023 Sep 13. Cancer Sci. 2023. PMID: 37702269 Free PMC article.
Here, we identify that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. ...Together, these results …
Here, we identify that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1), which plays an important role …
Molecular biology of BPIFB1 and its advances in disease.
Li J, Xu P, Wang L, Feng M, Chen D, Yu X, Lu Y. Li J, et al. Ann Transl Med. 2020 May;8(10):651. doi: 10.21037/atm-20-3462. Ann Transl Med. 2020. PMID: 32566588 Free PMC article. Review.
The 5' terminal of the BPIFB1 protein has a signal peptide sequence composed of 19 amino acids. BPIFB1 is abnormally expressed in nasopharyngeal carcinoma (NPC), gastric cancer, and other cancer tissues, regulate chronic infections and inflammation, in …
The 5' terminal of the BPIFB1 protein has a signal peptide sequence composed of 19 amino acids. BPIFB1 is abnormally expressed …
BPIFB1 inhibits vasculogenic mimicry via downregulation of GLUT1-mediated H3K27 acetylation in nasopharyngeal carcinoma.
Jiang X, Deng X, Wang J, Mo Y, Shi L, Wei F, Zhang S, Gong Z, He Y, Xiong F, Wang Y, Guo C, Xiang B, Zhou M, Liao Q, Li X, Li Y, Li G, Xiong W, Zeng Z. Jiang X, et al. Oncogene. 2022 Jan;41(2):233-245. doi: 10.1038/s41388-021-02079-8. Epub 2021 Nov 1. Oncogene. 2022. PMID: 34725462
BPIFB1 expression is substantially downregulated in NPC and is significantly associated with poor prognosis in patients with NPC. However, the specific molecular mechanism by which BPIFB1 regulates NPC is not well understood. In this study, we found that BPIFB1 …
BPIFB1 expression is substantially downregulated in NPC and is significantly associated with poor prognosis in patients with NPC. How …
BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression.
Wei F, Tang L, He Y, Wu Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Ni Q, Luo J, Li X, Li Y, Peng C, Chen X, Li G, Xiong W, Zeng Z. Wei F, et al. Cell Death Dis. 2018 Apr 1;9(4):432. doi: 10.1038/s41419-018-0409-0. Cell Death Dis. 2018. PMID: 29568064 Free PMC article.
Thus, we aimed to investigate the role of BPIFB1 in the radioresponse of NPC. Colony formation and cell survival results showed that BPIFB1 sensitized NPC cells to ionizing radiation. ...However, BPIFB1 inhibited this VTN-mediated radioresistance, ultimately …
Thus, we aimed to investigate the role of BPIFB1 in the radioresponse of NPC. Colony formation and cell survival results showed that …
BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM.
Wei F, Wu Y, Tang L, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Zhou M, Xiang B, Li X, Li Y, Li G, Xiong W, Zeng Z. Wei F, et al. Br J Cancer. 2018 Jan;118(2):233-247. doi: 10.1038/bjc.2017.385. Epub 2017 Nov 9. Br J Cancer. 2018. PMID: 29123267 Free PMC article.
Because metastasis represents the primary cause of NPC-related death, we explored the role of BPIFB1 in NPC migration and invasion. METHODS: The role of BPIFB1 in NPC metastasis was investigated in vitro and in vivo. ...Additionally, identification of two BPIFB1 …
Because metastasis represents the primary cause of NPC-related death, we explored the role of BPIFB1 in NPC migration and invasion. M …
Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis.
Ferré EMN, Nichols-Vinueza DX, Rosen LB, Burbelo PD, Fennelly KP, Pechacek J, Goldstein DM, Agharahimi A, Saksena A, Kleiner DE, Demirdag YY, Rajan A, Schrump DS, Holland SM, Freeman AF, Lionakis MS. Ferré EMN, et al. J Clin Immunol. 2024 Jul 1;44(7):156. doi: 10.1007/s10875-024-01760-3. J Clin Immunol. 2024. PMID: 38954150 Free PMC article.
We performed history and physical examination; laboratory, radiographic, histologic and pulmonary function evaluations; and measurement of the lung-directed autoantibodies KCNRG and BPIFB1 prior to and at 1- and 6-months following initiation of lymphocyte-directed immunomo …
We performed history and physical examination; laboratory, radiographic, histologic and pulmonary function evaluations; and measurement of t …
Quantitative proteomics revealed protein biomarkers to distinguish malignant pleural effusion from benign pleural effusion.
Dong T, Liang Y, Chen H, Li Y, Li Z, Gao X. Dong T, et al. J Proteomics. 2024 Jun 30;302:105201. doi: 10.1016/j.jprot.2024.105201. Epub 2024 May 18. J Proteomics. 2024. PMID: 38768894
Finally, significant survival and gene and protein expression analysis demonstrated BPIFB1, DPP4, HPRT1 and ABI3BP had high discriminating values. SIGNIFICANCE: We performed a 4D-DIA proteomics to determine the differentially expressed proteins in pleural effusion samples …
Finally, significant survival and gene and protein expression analysis demonstrated BPIFB1, DPP4, HPRT1 and ABI3BP had high discrimin …
Multi-omics analysis reveals a molecular landscape of the early recurrence and early metastasis in pan-cancer.
He DN, Wang N, Wen XL, Li XH, Guo Y, Fu SH, Xiong FF, Wu ZY, Zhu X, Gao XL, Wang ZZ, Wang HJ. He DN, et al. Front Genet. 2023 Apr 20;14:1061364. doi: 10.3389/fgene.2023.1061364. eCollection 2023. Front Genet. 2023. PMID: 37152984 Free PMC article.
Then, various analytical techniques, such as proportional hazard model and Fisher's exact test, were used to identify specific genes or immune characteristics associated with early cancer recurrence and metastasis. For example, we observed that the overexpression of BPI …
Then, various analytical techniques, such as proportional hazard model and Fisher's exact test, were used to identify specific genes or immu …
Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations.
Jin G, Zhu M, Yin R, Shen W, Liu J, Sun J, Wang C, Dai J, Ma H, Wu C, Yin Z, Huang J, Higgs BW, Xu L, Yao Y, Christiani DC, Amos CI, Hu Z, Zhou B, Shi Y, Lin D, Shen H. Jin G, et al. Am J Hum Genet. 2015 May 7;96(5):832-40. doi: 10.1016/j.ajhg.2015.03.009. Epub 2015 Apr 30. Am J Hum Genet. 2015. PMID: 25937444 Free PMC article.
Genome-wide association studies have successfully identified a subset of common variants associated with lung cancer risk. However, these variants explain only a fraction of lung cancer heritability. ...We identified three low-frequency missense variants in BAT2 (rs …
Genome-wide association studies have successfully identified a subset of common variants associated with lung cancer risk. However, t …
BPIFB1, Serving as a Downstream Effector of EBV-miR-BART4, Blocks Immune Escape of Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression.
Cai J, Xiao L, Liu J, Wang D, Zhou Y, Liao Z, Chen G. Cai J, et al. Biochem Genet. 2025 Feb;63(1):540-556. doi: 10.1007/s10528-024-10719-3. Epub 2024 Mar 11. Biochem Genet. 2025. PMID: 38467887
Mechanistically, BPIFB1 was found to repress the expression of STAT1, which was identified to be an upstream activator of PD-L1. Furthermore, the EBV-encoded miR-BART4 overexpressed in NPC cells could directly target and inhibit BPIFB1. This study provided a compreh …
Mechanistically, BPIFB1 was found to repress the expression of STAT1, which was identified to be an upstream activator of PD-L1. Furt …
26 results