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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 32
1994 72
1995 135
1996 216
1997 268
1998 340
1999 361
2000 416
2001 416
2002 475
2003 454
2004 493
2005 529
2006 626
2007 643
2008 667
2009 754
2010 830
2011 837
2012 897
2013 893
2014 973
2015 1072
2016 1121
2017 1135
2018 1192
2019 1302
2020 1462
2021 1509
2022 1435
2023 1306
2024 408

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20,833 results

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Page 1
BRCA1 as target for breast cancer prevention and therapy.
Romagnolo AP, Romagnolo DF, Selmin OI. Romagnolo AP, et al. Anticancer Agents Med Chem. 2015;15(1):4-14. doi: 10.2174/1871520614666141020153543. Anticancer Agents Med Chem. 2015. PMID: 25329591 Review.
The Breast Cancer 1 protein (BRCA1) is a tumor suppressor involved in basic cellular functions necessary for cell replication and DNA synthesis, but reduced expression of BRCA1, due to mutations or epigenetic inactivation, leads to impaired mammary gland diff …
The Breast Cancer 1 protein (BRCA1) is a tumor suppressor involved in basic cellular functions necessary for cell replication …
BRCA1 and BRCA2 mutations and breast cancer.
Narod SA, Salmena L. Narod SA, et al. Discov Med. 2011 Nov;12(66):445-53. Discov Med. 2011. PMID: 22127115 Free article.
The goals of treatment for a woman with a BRCA-associated breast cancer should be to prevent recurrence of the initial cancer and to prevent second primary breast and ovarian cancers. Women with breast cancer and a BRCA1 mutation may benefit fro …
The goals of treatment for a woman with a BRCA-associated breast cancer should be to prevent recurrence of the initial cancer …
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.
Yoshida K, Miki Y. Yoshida K, et al. Cancer Sci. 2004 Nov;95(11):866-71. doi: 10.1111/j.1349-7006.2004.tb02195.x. Cancer Sci. 2004. PMID: 15546503 Free article. Review.
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. ...The functions of BRCA proteins are also linked to distinct and specific phosphorylation events …
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predis …
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.
Paul A, Paul S. Paul A, et al. Front Biosci (Landmark Ed). 2014 Jan 1;19(4):605-18. doi: 10.2741/4230. Front Biosci (Landmark Ed). 2014. PMID: 24389207 Free PMC article. Review.
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. ...Mutations of BRCA1/2 genes greatly increase lifetime risk to develop breast and ovarian cancer and these mutations are frequently …
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity. ...Mutations …
Skin cancer risk in BRCA1/2 mutation carriers.
Gumaste PV, Penn LA, Cymerman RM, Kirchhoff T, Polsky D, McLellan B. Gumaste PV, et al. Br J Dermatol. 2015 Jun;172(6):1498-1506. doi: 10.1111/bjd.13626. Epub 2015 Apr 29. Br J Dermatol. 2015. PMID: 25524463 Free PMC article. Review.
Women with BRCA1/2 mutations have an elevated risk of breast and ovarian cancer. These patients and their clinicians are often concerned about their risk for other cancers, including skin cancer. Research evaluating the association between BRCA1 …
Women with BRCA1/2 mutations have an elevated risk of breast and ovarian cancer. These patients and their clinicians are often …
Which Genes for Hereditary Breast Cancer?
Narod SA. Narod SA. N Engl J Med. 2021 Feb 4;384(5):471-473. doi: 10.1056/NEJMe2035083. Epub 2021 Jan 20. N Engl J Med. 2021. PMID: 33471975 No abstract available.
BRCA1 in cancer, cell cycle and genomic stability.
Jhanwar-Uniyal M. Jhanwar-Uniyal M. Front Biosci. 2003 Sep 1;8:s1107-17. doi: 10.2741/1131. Front Biosci. 2003. PMID: 12957814 Review.
The BRCA1 gene was isolated in 1994; germline mutations of this gene are known to confer susceptibility to breast and ovarian cancer in high-risk families. ...Thus, BRCA1 plays a significant role in maintaining genomic stability and serves as a tumor suppress …
The BRCA1 gene was isolated in 1994; germline mutations of this gene are known to confer susceptibility to breast and ovarian canc …
An overview of cancer genetics with focus on involvement of BRCA1/2 genes in breast carcinomas.
Tahir DE, Rehman MS, Rehman MU. Tahir DE, et al. J Pak Med Assoc. 2020 Jul;70(7):1240-1247. doi: 10.5455/JPMA.20351. J Pak Med Assoc. 2020. PMID: 32799280 Free article. Review.
Other than the well-known breast cancer susceptibility 1/2 genes, there are several other genes involved in the development of breast and ovarian cancers. However, since the past two decades the focus of research has been on and breast cancer su …
Other than the well-known breast cancer susceptibility 1/2 genes, there are several other genes involved in the develop …
BRCA1 and BRCA2--breast cancer susceptibility genes.
Hofmann W, Schlag PM. Hofmann W, et al. J Cancer Res Clin Oncol. 2000 Sep;126(9):487-96. doi: 10.1007/s004320000140. J Cancer Res Clin Oncol. 2000. PMID: 11003560 Review.
Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibi …
Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast can …
Role of BRCA1 mutation screening in the management of familial ovarian cancer.
Berchuck A, Cirisano F, Lancaster JM, Schildkraut JM, Wiseman RW, Futreal A, Marks JR. Berchuck A, et al. Am J Obstet Gynecol. 1996 Sep;175(3 Pt 1):738-46. doi: 10.1053/ob.1996.v175.a74288. Am J Obstet Gynecol. 1996. PMID: 8828444 Review.
It is now thought that > 90% of familial ovarian cancer is due to inherited mutations in the BRCA1 breast-ovarian cancer susceptibility gene on chromosome 17q. ...With the ability to identify inherited mutations in BRCA1, prophylactic oophorectomy a …
It is now thought that > 90% of familial ovarian cancer is due to inherited mutations in the BRCA1 breast-ovarian cancer …
20,833 results
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