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Year Number of Results
1997 1
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124 results

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Page 1
The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication.
Tarsounas M, Sung P. Tarsounas M, et al. Nat Rev Mol Cell Biol. 2020 May;21(5):284-299. doi: 10.1038/s41580-020-0218-z. Epub 2020 Feb 24. Nat Rev Mol Cell Biol. 2020. PMID: 32094664 Free PMC article. Review.
Understanding the functional crosstalk between BRCA1-BARD1 and its cofactors and antagonists will illuminate the molecular basis of cancers that arise from a deficiency or misregulation of chromosome damage repair and replication fork maintenance. ...In this Review, …
Understanding the functional crosstalk between BRCA1-BARD1 and its cofactors and antagonists will illuminate the molecular bas …
The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination.
Wu D, Huang H, Chen T, Gai X, Li Q, Wang C, Yao J, Liu Y, Cai S, Yu X. Wu D, et al. Cell Discov. 2023 Oct 3;9(1):99. doi: 10.1038/s41421-023-00590-8. Cell Discov. 2023. PMID: 37789001 Free PMC article.
Similarly, the BRCA1/BARD1 complex associates with pre-rRNA in somatic cells, which not only forms nuclear foci in response to DSBs, but also targets the BRCA1/BARD1 complex to DSBs. The interactions between the BRCT domains of the BRC …
Similarly, the BRCA1/BARD1 complex associates with pre-rRNA in somatic cells, which not only forms nuclear foci in resp …
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I, Dello Stritto MR, Mütze M, Braunshier S, Mengoli V, Reginato G, Võ HMP, Jimeno S, Acharya A, Roy M, Sanchez A, Halder S, Howard SM, Guérois R, Huertas P, Noordermeer SM, Seidel R, Cejka P. Ceppi I, et al. Nature. 2024 Oct;634(8033):492-500. doi: 10.1038/s41586-024-07909-9. Epub 2024 Sep 11. Nature. 2024. PMID: 39261728 Free PMC article.
In the DNA2-dependent pathway, BRCA1-BARD1 stimulates DNA unwinding by the Werner or Bloom helicase. Together with MRE11-RAD50-NBS1 and phosphorylated CtIP, BRCA1-BARD1 forms the BRCA1-C complex(17,18), which stimulates resection synergistically …
In the DNA2-dependent pathway, BRCA1-BARD1 stimulates DNA unwinding by the Werner or Bloom helicase. Together with MRE11-RAD50 …
Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.
Salunkhe S, Daley JM, Kaur H, Tomimatsu N, Xue C, Raina VB, Jasper AM, Rogers CM, Li W, Zhou S, Mojidra R, Kwon Y, Fang Q, Ji JH, Badamchi Shabestari A, Fitzgerald O, Dinh H, Mukherjee B, Habib AA, Hromas R, Mazin AV, Wasmuth EV, Olsen SK, Libich DS, Zhou D, Zhao W, Greene EC, Burma S, Sung P. Salunkhe S, et al. Nature. 2024 Oct;634(8033):482-491. doi: 10.1038/s41586-024-07910-2. Epub 2024 Sep 11. Nature. 2024. PMID: 39261729 Free PMC article.
DNA end resection is mechanistically intricate and reliant on the tumour suppressor complex BRCA1-BARD1 (ref. (2)). Specifically, three distinct nuclease entities-the 5'-3' exonuclease EXO1 and heterodimeric complexes of the DNA endonuclease DNA2, with …
DNA end resection is mechanistically intricate and reliant on the tumour suppressor complex BRCA1-BARD1 (ref. (2)). Spe …
BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.
Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. Zhao W, et al. Nature. 2017 Oct 19;550(7676):360-365. doi: 10.1038/nature24060. Epub 2017 Oct 4. Nature. 2017. PMID: 28976962 Free PMC article.
The tumour suppressor complex BRCA1-BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. ...Mechanistically, BRCA1-BARD1 promotes the assembly of the synaptic complex, an essential intermediate in RAD51 …
The tumour suppressor complex BRCA1-BARD1 functions in the repair of DNA double-stranded breaks by homologous recombina …
Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.
Dai L, Dai Y, Han J, Huang Y, Wang L, Huang J, Zhou Z. Dai L, et al. Mol Cell. 2021 Jul 1;81(13):2765-2777.e6. doi: 10.1016/j.molcel.2021.05.010. Epub 2021 Jun 7. Mol Cell. 2021. PMID: 34102105 Free article.
The BRCA1-BARD1 complex directs the DNA double-strand break (DSB) repair pathway choice to error-free homologous recombination (HR) during the S-G2 stages. ...Together, this study elucidates the mechanism of BRCA1-BARD1 complex recruitmen …
The BRCA1-BARD1 complex directs the DNA double-strand break (DSB) repair pathway choice to error-free homologous recomb …
Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex.
Dutta A, Ji JH, Syed S, Fang Q, Mukhopadhyay P, Wang H, Loranc E, Medina D, Abdulsahib S, Zhou S, Tovar M, Wang J, Benoit JM, Liang F, Tomimatsu N, Nyalwidhe JO, Dray E, Verway-Cohen A, McDonald DT, de la Peña Avalos B, Li W, Herrero AO, Fitzgerald O, Taylor AB, Kwon Y, Semmes OJ, Tsai MS, Rao M, Hromas R, Burma S, Chen Y, Mazin AV, Wasmuth E, Olsen SK, Zhou D, Bishop AJR, Zhao W, Kupfer GM, Sung P. Dutta A, et al. Nat Struct Mol Biol. 2026 Apr;33(4):615-630. doi: 10.1038/s41594-026-01778-8. Epub 2026 Mar 31. Nat Struct Mol Biol. 2026. PMID: 41917467 Free PMC article.
BRCA1-BARD1 alleviates the inhibitory effect of RAD52 on SETX-mediated R-loop unwinding. ...Thus, our results delineate the molecular basis for functional synergy between SETX and BRCA1-BARD1 in R-loop resolution and the mitigation of transcription-rep …
BRCA1-BARD1 alleviates the inhibitory effect of RAD52 on SETX-mediated R-loop unwinding. ...Thus, our results delineate the mo …
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Tsukada K, Jones SE, Bannister J, Durin MA, Vendrell I, Fawkes M, Fischer R, Kessler BM, Chapman JR, Blackford AN. Tsukada K, et al. Mol Cell. 2024 Feb 15;84(4):640-658.e10. doi: 10.1016/j.molcel.2023.12.040. Epub 2024 Jan 23. Mol Cell. 2024. PMID: 38266639 Free article.
Here, we identify a negative genetic interaction between BLM loss and deficiency in the BRCA1-BARD1 tumor suppressor complex. We show that this is due to a previously overlooked role for BARD1 in recruiting SLX4 to resolve DNA intermediates left unprocessed b …
Here, we identify a negative genetic interaction between BLM loss and deficiency in the BRCA1-BARD1 tumor suppressor comple …
Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.
Wang M, Li W, Tomimatsu N, Yu CH, Ji JH, Alejo S, Witus SR, Alimbetov D, Fitzgerald O, Wu B, Wang Q, Huang Y, Gan Y, Dong F, Kwon Y, Sareddy GR, Curiel TJ, Habib AA, Hromas R, Dos Santos Passos C, Yao T, Ivanov DN, Brzovic PS, Burma S, Klevit RE, Zhao W. Wang M, et al. Mol Cell. 2023 Oct 19;83(20):3679-3691.e8. doi: 10.1016/j.molcel.2023.09.015. Epub 2023 Oct 4. Mol Cell. 2023. PMID: 37797621 Free PMC article.
The importance of BRCA1-BARD1 E3 activity in tumor suppression remains highly controversial, mainly stemming from studying mutant ligase-deficient BRCA1-BARD1 species that we show here still retain significant ligase activity. Using full-length BRCA …
The importance of BRCA1-BARD1 E3 activity in tumor suppression remains highly controversial, mainly stemming from studying mut …
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL. Wang JQ, et al. Nature. 2022 Aug;608(7922):413-420. doi: 10.1038/s41586-022-05006-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922515
On one hand, AMPK increases LXRalpha by decreasing its ubiquitin ligases BRCA1/BARD1. On the other hand, AMPK suppresses SREBP1 that controls lipogenesis. Anti-ASGR1 neutralizing antibody lowers lipid levels by increasing cholesterol excretion, and shows synergistic …
On one hand, AMPK increases LXRalpha by decreasing its ubiquitin ligases BRCA1/BARD1. On the other hand, AMPK suppresses SREBP …
124 results