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Year Number of Results
1978 1
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1987 2
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1989 1
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44 results

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Page 1
Effects of alcohol on other hepatotoxins.
Zimmerman HJ. Zimmerman HJ. Alcohol Clin Exp Res. 1986 Jan-Feb;10(1):3-15. doi: 10.1111/j.1530-0277.1986.tb05605.x. Alcohol Clin Exp Res. 1986. PMID: 3083708 Review. No abstract available.
Selection of new chemical entities with decreased potential for adverse drug reactions.
Park KB, Dalton-Brown E, Hirst C, Williams DP. Park KB, et al. Eur J Pharmacol. 2006 Nov 7;549(1-3):1-8. doi: 10.1016/j.ejphar.2006.08.025. Epub 2006 Aug 26. Eur J Pharmacol. 2006. PMID: 16979156 Review.
It is well established that the toxicities of model hepatotoxins, such as acetaminophen, furosemide, bromobenzene and methapyrilene can be correlated with the generation of chemically reactive metabolites, which can be detected by measurement of the irreversible bin …
It is well established that the toxicities of model hepatotoxins, such as acetaminophen, furosemide, bromobenzene and methapyr …
Toxicophores: investigations in drug safety.
Williams DP. Williams DP. Toxicology. 2006 Sep 1;226(1):1-11. doi: 10.1016/j.tox.2006.05.101. Epub 2006 Jun 9. Toxicology. 2006. PMID: 16860917
It is well established that the toxicities of model hepatotoxins, such as acetaminophen, furosemide, bromobenzene and methapyrilene can be correlated with the generation of chemically reactive metabolites, which can be detected by measurement of the irreversible bin …
It is well established that the toxicities of model hepatotoxins, such as acetaminophen, furosemide, bromobenzene and methapyr …
Effect of sublethal liver injury on doxorubicin metabolism.
August DA, Halter S, Brenner DE. August DA, et al. Clin Cancer Res. 1995 Mar;1(3):351-8. Clin Cancer Res. 1995. PMID: 9815991
Centrilobular hepatocyte contribution to doxorubicin (DOX) metabolism and myelotoxicity was probed with bromobenzene (BRB), a known centrilobular hepatotoxin. New Zealand White rabbits were given DOX, 3 mg/kg i.v. ...
Centrilobular hepatocyte contribution to doxorubicin (DOX) metabolism and myelotoxicity was probed with bromobenzene (BRB), a known c …
Alterations in xenobiotic metabolism in the long-lived Little mice.
Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G. Amador-Noguez D, et al. Aging Cell. 2007 Aug;6(4):453-70. doi: 10.1111/j.1474-9726.2007.00300.x. Epub 2007 May 23. Aging Cell. 2007. PMID: 17521389 Free PMC article.
Here, we show that this up-regulation is associated with a potent increase in resistance against the adverse effects of a variety of xenobiotics, including the hepatotoxins acetaminophen and bromobenzene and the paralyzing agent zoxazolamine. The classic xenobiotic …
Here, we show that this up-regulation is associated with a potent increase in resistance against the adverse effects of a variety of xenobio …
Histochemical detection of lipid peroxidation in the liver of bromobenzene-poisoned mice.
Pompella A, Maellaro E, Casini AF, Comporti M. Pompella A, et al. Am J Pathol. 1987 Nov;129(2):295-301. Am J Pathol. 1987. PMID: 3674204 Free PMC article.
The technique was based on the detection of aldehyde functions with the use of the Schiff's reagent. The study was carried out on bromobenzene-intoxicated mice, which generally exhibit levels of lipid peroxidation considerably higher than those observed in the case of othe …
The technique was based on the detection of aldehyde functions with the use of the Schiff's reagent. The study was carried out on bromobe …
Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.
Smith AC, Berman ML, James RC, Harbison RD. Smith AC, et al. Biochem Pharmacol. 1983 Dec 1;32(23):3531-9. doi: 10.1016/0006-2952(83)90299-x. Biochem Pharmacol. 1983. PMID: 6651874
Likewise, hyperthyroidism did not enhance the hepatotoxicity of another hepatotoxin bromobenzene. The in vitro enzymatic activities associated with cytochrome P-450-dependent metabolism and glutathione S-transferase conjugation activity were markedly altered in hype …
Likewise, hyperthyroidism did not enhance the hepatotoxicity of another hepatotoxin bromobenzene. The in vitro enzymatic activ …
Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices.
Wang BH, Zuzel KA, Rahman K, Billington D. Wang BH, et al. Toxicology. 1998 Apr 3;126(3):213-22. doi: 10.1016/s0300-483x(98)00018-3. Toxicology. 1998. PMID: 9674969
Precision-cut liver slices from phenobarbital-treated rats were incubated for up to 8 h with the industrial solvent and hepatotoxin bromobenzene at a final concentration of 1 mM. Phenobarbital pretreatment potentiates bromobenzene hepatotoxicity by inducing t …
Precision-cut liver slices from phenobarbital-treated rats were incubated for up to 8 h with the industrial solvent and hepatotoxin …
Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices.
Wang BH, Zuzel KA, Rahman K, Billington D. Wang BH, et al. Toxicology. 1999 Feb 15;132(2-3):215-25. doi: 10.1016/s0300-483x(99)00004-9. Toxicology. 1999. PMID: 10433384
Precision-cut liver slices from phenobarbital-induced rats were incubated for 6 h with the model hepatotoxin bromobenzene (BB) at a final concentration of 1 mM. Severe toxicity was indicated by a decreased K+, adenosine triphosphate and glutathione (GSH) content of …
Precision-cut liver slices from phenobarbital-induced rats were incubated for 6 h with the model hepatotoxin bromobenzene (BB) …
Enhancing effect of zinc on hepatoprotectivity of epigallocatechin gallate in isolated rat hepatocytes.
Kagaya N, Kawase M, Maeda H, Tagawa Y, Nagashima H, Ohmori H, Yagi K. Kagaya N, et al. Biol Pharm Bull. 2002 Sep;25(9):1156-60. doi: 10.1248/bpb.25.1156. Biol Pharm Bull. 2002. PMID: 12230108 Free article.
The influence of metal ions (Fe2+, Cu2+, Zn2+) on the hepatoprotective activity of epigallocatechin gallate (EGCG) against hepatotoxin-induced cell injury was investigated. Primary cultures of rat hepatocytes were treated with a well-known hepatotoxin, bromobenze …
The influence of metal ions (Fe2+, Cu2+, Zn2+) on the hepatoprotective activity of epigallocatechin gallate (EGCG) against hepatotoxin …
44 results