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2005 1
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Page 1
Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury.
Timofeev I, Nortje J, Al-Rawi PG, Hutchinson PJ, Gupta AK. Timofeev I, et al. Among authors: hutchinson pj. J Cereb Blood Flow Metab. 2013 Mar;33(3):422-7. doi: 10.1038/jcbfm.2012.186. Epub 2012 Dec 12. J Cereb Blood Flow Metab. 2013. PMID: 23232949 Free PMC article. Clinical Trial.
Four tissue states were defined based on pH(bt) and P(bt)O(2): 1--low P(bt)O(2)/pH(bt), 2--low pH(bt)/normal P(bt)O(2), 3--normal pH(bt)/low P(bt)O(2), and 4--normal pH(bt)/P(bt)O(2)). ...The state 2 was a sign …
Four tissue states were defined based on pH(bt) and P(bt)O(2): 1--low P(bt)O(2)/pH(bt), 2--low pH(bt)/nor …
Studies on B Cells in the Fruit-Eating Black Flying Fox (Pteropus alecto).
Periasamy P, Hutchinson PE, Chen J, Bonne I, Shahul Hameed SS, Selvam P, Hey YY, Fink K, Irving AT, Dutertre CA, Baker M, Crameri G, Wang LF, Alonso S. Periasamy P, et al. Among authors: hutchinson pe. Front Immunol. 2019 Mar 14;10:489. doi: 10.3389/fimmu.2019.00489. eCollection 2019. Front Immunol. 2019. PMID: 30930908 Free PMC article.
Comparison of Bone Tunnel and Cortical Surface Tendon-to-Bone Healing in a Rabbit Model of Biceps Tenodesis.
Tan H, Wang D, Lebaschi AH, Hutchinson ID, Ying L, Deng XH, Rodeo SA, Warren RF. Tan H, et al. Among authors: hutchinson id. J Bone Joint Surg Am. 2018 Mar 21;100(6):479-486. doi: 10.2106/JBJS.17.00797. J Bone Joint Surg Am. 2018. PMID: 29557864 Free PMC article.
RESULTS: Biomechanical testing demonstrated no significant difference between the groups in mean failure loads (BT: 56.8 28.8 N, SA: 55.8 14.9 N; p = 0.92) or stiffness (BT: 26.3 16.6 N/mm, SA: 32.3 9.6 N/mm; p = 0.34). Micro-CT analysis demonstrated no significant …
RESULTS: Biomechanical testing demonstrated no significant difference between the groups in mean failure loads (BT: 56.8 28.8 N, SA: …
Observations on the Cerebral Effects of Refractory Intracranial Hypertension After Severe Traumatic Brain Injury.
Donnelly J, Smielewski P, Adams H, Zeiler FA, Cardim D, Liu X, Fedriga M, Hutchinson P, Menon DK, Czosnyka M. Donnelly J, et al. Among authors: hutchinson p. Neurocrit Care. 2020 Apr;32(2):437-447. doi: 10.1007/s12028-019-00748-x. Neurocrit Care. 2020. PMID: 31240622 Free PMC article.
METHODS: Thirty-three severe TBI patients from a single center who developed severe refractory intracranial hypertension (ICP > 40 mm Hg for longer than 1 h) with ICP, arterial blood pressure, and brain tissue oxygenation (P(BT)O(2)) monitoring (subcohort, n = 9) were s …
METHODS: Thirty-three severe TBI patients from a single center who developed severe refractory intracranial hypertension (ICP > 40 mm Hg …
Development of CAPER peptides for the treatment of triple negative breast cancer.
Chilewski SD, Bhosale D, Dees S, Hutchinson I, Trimble R, Pontiggia L, Mercier I, Jasmin JF. Chilewski SD, et al. Among authors: hutchinson i. Cell Cycle. 2020 Feb;19(4):432-447. doi: 10.1080/15384101.2020.1711579. Epub 2020 Jan 13. Cell Cycle. 2020. PMID: 31931653 Free PMC article.
These CAPER peptides result in a decrease in cell number and an increase in apoptosis in two TNBC cell lines, MDA-MB-231 and BT-549, while having no effect on the non-tumorigenic cell line MCF 10A. Additionally, two modes of action were demonstrated which appear to be cell …
These CAPER peptides result in a decrease in cell number and an increase in apoptosis in two TNBC cell lines, MDA-MB-231 and BT-549, …
Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location.
Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ. Timofeev I, et al. Among authors: hutchinson pj. J Neurotrauma. 2011 Jun;28(6):849-60. doi: 10.1089/neu.2010.1656. J Neurotrauma. 2011. PMID: 21488707 Free PMC article.
Perilesional tissue chemistry exhibited a significant independent relationship with ICP, P(bt)O(2) and CPP thresholds, with increasing LP ratio in response to decrease in P(bt)O(2) and CPP, and increase in ICP. ...These differences remained significant following adj …
Perilesional tissue chemistry exhibited a significant independent relationship with ICP, P(bt)O(2) and CPP thresholds, with increasin …
Developmental toxicity of benzotriazole in the protochordate Ciona intestinalis (Chordata, Ascidiae).
Kadar E, Dashfield S, Hutchinson TH. Kadar E, et al. Among authors: hutchinson th. Anal Bioanal Chem. 2010 Jan;396(2):641-7. doi: 10.1007/s00216-009-3293-8. Epub 2009 Nov 24. Anal Bioanal Chem. 2010. PMID: 19937003
Benzotriazoles (BT) are applied as anticorrosive and de-icing agents and have been detected in a variety of aquatic ecosystems and municipal wastewater effluents. ...
Benzotriazoles (BT) are applied as anticorrosive and de-icing agents and have been detected in a variety of aquatic ecosystems and mu …
Phospholipase C from two bacterial strains acts differently on pure phospholipids and membrane bound glycosylphosphatidylinositol (GPI) anchors.
Rastogi A, Hutchinson TE, Pereira BM. Rastogi A, et al. Among authors: hutchinson te. Indian J Biochem Biophys. 2005 Apr;42(2):92-9. Indian J Biochem Biophys. 2005. PMID: 23923568
PLC-Bc showed a preference for phosphatidylinositol, while PLC-Bt favoured phosphatidylcholine as the substrate. Although both the enzymes were able to hydrolyze pure phosphatidylinositol, distinct differences were observed in their activity on phosphatidylinositol-anchore …
PLC-Bc showed a preference for phosphatidylinositol, while PLC-Bt favoured phosphatidylcholine as the substrate. Although both the en …