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PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.
Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M. Halaban R, et al. Among authors: bacchiocchi a. Pigment Cell Melanoma Res. 2010 Apr;23(2):190-200. doi: 10.1111/j.1755-148X.2010.00685.x. Epub 2010 Feb 10. Pigment Cell Melanoma Res. 2010. PMID: 20149136 Free PMC article.
GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation.
Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D; Yale Center for Mendelian Genomics, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. Lim YH, et al. Among authors: bacchiocchi a. Am J Hum Genet. 2016 Aug 4;99(2):443-50. doi: 10.1016/j.ajhg.2016.06.010. Epub 2016 Jul 28. Am J Hum Genet. 2016. PMID: 27476652 Free PMC article.
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Wickens P, Kluender H, Dixon J, Brennan C, Achebe F, Bacchiocchi A, Bankston D, Bierer D, Brands M, Braun D, Brown MS, Chuang CY, Dumas J, Enyedy I, Hofilena G, Hong Z, Housley T, Jones B, Khire U, Kreiman C, Kumarasinghe E, Lowinger T, Ott-Morgan R, Perkins L, Phillips B, Schoenleber R, Scott WJ, Sheeler R, Redman A, Sun X, Taylor I, Wang L, Wilhelm S, Zhang X, Zhang M, Sullivan E, Carter C, Miglarese M, Levy J. Wickens P, et al. Among authors: bacchiocchi a. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4378-81. doi: 10.1016/j.bmcl.2007.02.075. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17574417
Clonal growth of human melanocytes using cell-free extracellular matrix.
Zhang R, Premi S, Kilic SS, Bacchiocchi A, Halaban R, Brash DE. Zhang R, et al. Among authors: bacchiocchi a. Pigment Cell Melanoma Res. 2013 Nov;26(6):925-7. doi: 10.1111/pcmr.12159. Epub 2013 Sep 19. Pigment Cell Melanoma Res. 2013. PMID: 24034857 Free PMC article. No abstract available.
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors.
Choi J, Landrette SF, Wang T, Evans P, Bacchiocchi A, Bjornson R, Cheng E, Stiegler AL, Gathiaka S, Acevedo O, Boggon TJ, Krauthammer M, Halaban R, Xu T. Choi J, et al. Among authors: bacchiocchi a. Pigment Cell Melanoma Res. 2014 Mar;27(2):253-62. doi: 10.1111/pcmr.12197. Epub 2014 Jan 6. Pigment Cell Melanoma Res. 2014. PMID: 24283590 Free PMC article.
A novel anti-melanoma SRC-family kinase inhibitor.
Halaban R, Bacchiocchi A, Straub R, Cao J, Sznol M, Narayan D, Allam A, Krauthammer M, Mansour TS. Halaban R, et al. Among authors: bacchiocchi a. Oncotarget. 2019 Mar 19;10(23):2237-2251. doi: 10.18632/oncotarget.26787. eCollection 2019 Mar 19. Oncotarget. 2019. PMID: 31040916 Free PMC article.
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Krauthammer M, et al. Among authors: bacchiocchi a. Nat Genet. 2015 Sep;47(9):996-1002. doi: 10.1038/ng.3361. Epub 2015 Jul 27. Nat Genet. 2015. PMID: 26214590 Free PMC article.
25 results