Bach A - Search Results

1

A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.

Tran KT, Pallesen JS, Solbak SMØ, Narayanan D, Baig A, Zang J, Aguayo-Orozco A, Carmona RMC, Garcia AD, Bach A. Tran KT, et al. Among authors: bach a. J Med Chem. 2019 Sep 12;62(17):8028-8052. doi: 10.1021/acs.jmedchem.9b00723. Epub 2019 Aug 27. J Med Chem. 2019. PMID: 31411465 Free article.

2

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Chi CN, Olsen TB, Pedersen SW, Røder MU, Pang GF, Clausen RP, Jemth P, Strømgaard K. Bach A, et al. J Med Chem. 2008 Oct 23;51(20):6450-9. doi: 10.1021/jm800836w. Epub 2008 Sep 24. J Med Chem. 2008. PMID: 18811137

3

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1.

Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Bach A, et al. Org Biomol Chem. 2010 Oct 7;8(19):4281-8. doi: 10.1039/c0ob00025f. Epub 2010 Jul 29. Org Biomol Chem. 2010. PMID: 20668766 Free PMC article.

4

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Eildal JN, Stuhr-Hansen N, Deeskamp R, Gottschalk M, Pedersen SW, Kristensen AS, Strømgaard K. Bach A, et al. J Med Chem. 2011 Mar 10;54(5):1333-46. doi: 10.1021/jm1013924. Epub 2011 Feb 15. J Med Chem. 2011. PMID: 21322614

5

Design, synthesis, and characterization of fatty acid derivatives of a dimeric peptide-based postsynaptic density-95 (PSD-95) inhibitor.

Nissen KB, Andersen JJ, Haugaard-Kedström LM, Bach A, Strømgaard K. Nissen KB, et al. Among authors: bach a. J Med Chem. 2015 Feb 12;58(3):1575-80. doi: 10.1021/jm501755d. Epub 2015 Jan 30. J Med Chem. 2015. PMID: 25590984

6

Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies.

Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D. Bach A, et al. J Med Chem. 2015 Dec 10;58(23):9258-72. doi: 10.1021/acs.jmedchem.5b01188. Epub 2015 Nov 23. J Med Chem. 2015. PMID: 26560855

7

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.

Pallesen JS, Tran KT, Bach A. Pallesen JS, et al. Among authors: bach a. J Med Chem. 2018 Sep 27;61(18):8088-8103. doi: 10.1021/acs.jmedchem.8b00358. Epub 2018 May 29. J Med Chem. 2018. PMID: 29750408

8

Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.

Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A. Solbak SMØ, et al. Among authors: bach a. J Med Chem. 2020 Feb 13;63(3):1156-1177. doi: 10.1021/acs.jmedchem.9b01492. Epub 2020 Jan 23. J Med Chem. 2020. PMID: 31922756

9

The dynamics of linear polyubiquitin.

Jussupow A, Messias AC, Stehle R, Geerlof A, Solbak SMØ, Paissoni C, Bach A, Sattler M, Camilloni C. Jussupow A, et al. Among authors: bach a. Sci Adv. 2020 Oct 14;6(42):eabc3786. doi: 10.1126/sciadv.abc3786. Print 2020 Oct. Sci Adv. 2020. PMID: 33055165 Free PMC article.

10

Identification of Novel Fragments Binding to the PDZ1-2 Domain of PSD-95.

Zang J, Ye F, Solbak SMØ, Høj LJ, Zhang M, Bach A. Zang J, et al. Among authors: bach a. ChemMedChem. 2021 Mar 18;16(6):949-954. doi: 10.1002/cmdc.202000865. Epub 2020 Dec 30. ChemMedChem. 2021. PMID: 33305877

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