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The degradation signal in a short-lived protein.
Bachmair A, Varshavsky A. Bachmair A, et al. Cell. 1989 Mar 24;56(6):1019-32. doi: 10.1016/0092-8674(89)90635-1. Cell. 1989. PMID: 2538246
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's degradation signal. ...The mechanistic significance of the second determinant is illuminated by the finding that in a targeted, short …
Our previous work has shown that the amino-terminal residue of a short-lived protein is a distinct component of the protein's …
How cells coordinate waste removal through their major proteolytic pathways.
Martens S, Bachmair A. Martens S, et al. Among authors: bachmair a. Nat Cell Biol. 2015 Jul;17(7):841-2. doi: 10.1038/ncb3198. Nat Cell Biol. 2015. PMID: 26123109
A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation....
A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation....
Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors.
Gibbs DJ, Md Isa N, Movahedi M, Lozano-Juste J, Mendiondo GM, Berckhan S, Marín-de la Rosa N, Vicente Conde J, Sousa Correia C, Pearce SP, Bassel GW, Hamali B, Talloji P, Tomé DF, Coego A, Beynon J, Alabadí D, Bachmair A, León J, Gray JE, Theodoulou FL, Holdsworth MJ. Gibbs DJ, et al. Among authors: bachmair a. Mol Cell. 2014 Feb 6;53(3):369-79. doi: 10.1016/j.molcel.2013.12.020. Epub 2014 Jan 23. Mol Cell. 2014. PMID: 24462115 Free PMC article.
Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). ...
Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant …
Protein sumoylation and phosphorylation intersect in Arabidopsis signaling.
Nukarinen E, Tomanov K, Ziba I, Weckwerth W, Bachmair A. Nukarinen E, et al. Among authors: bachmair a. Plant J. 2017 Aug;91(3):505-517. doi: 10.1111/tpj.13575. Epub 2017 Jun 4. Plant J. 2017. PMID: 28419593 Free PMC article.
Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis.
Yin XJ, Volk S, Ljung K, Mehlmer N, Dolezal K, Ditengou F, Hanano S, Davis SJ, Schmelzer E, Sandberg G, Teige M, Palme K, Pickart C, Bachmair A. Yin XJ, et al. Among authors: bachmair a. Plant Cell. 2007 Jun;19(6):1898-911. doi: 10.1105/tpc.107.052035. Epub 2007 Jun 22. Plant Cell. 2007. PMID: 17586653 Free PMC article.
Auxin and cytokinin levels are changed, and the plants show a decreased response to exogenously added auxin. Changes in the abundance of PIN family auxin transport proteins and synthetic lethality with a mutation in the auxin transport regulator BIG suggest that the …
Auxin and cytokinin levels are changed, and the plants show a decreased response to exogenously added auxin. Changes in the abundance …
In vivo half-life of a protein is a function of its amino-terminal residue.
Bachmair A, Finley D, Varshavsky A. Bachmair A, et al. Science. 1986 Oct 10;234(4773):179-86. doi: 10.1126/science.3018930. Science. 1986. PMID: 3018930
When a chimeric gene encoding a ubiquitin-beta-galactosidase fusion protein is expressed in the yeast Saccharomyces cerevisiae, ubiquitin is cleaved off the nascent fusion protein, yielding a deubiquitinated beta-galactosidase (beta gal). ...Thus the recognit …
When a chimeric gene encoding a ubiquitin-beta-galactosidase fusion protein is expressed in the yeast Saccharomyces cerevisiae …
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.
Chau V, Tobias JW, Bachmair A, Marriott D, Ecker DJ, Gonda DK, Varshavsky A. Chau V, et al. Among authors: bachmair a. Science. 1989 Mar 24;243(4898):1576-83. doi: 10.1126/science.2538923. Science. 1989. PMID: 2538923
The ubiquitin-dependent degradation of a test protein beta-galactosidase (beta gal) is preceded by ubiquitination of beta gal. ...The experiments with ubiquitin mutated at its Lys48 residue indicate that the multiubiquitin chain in a targeted protein is essential fo …
The ubiquitin-dependent degradation of a test protein beta-galactosidase (beta gal) is preceded by ubiquitination of beta gal. ...The …
Universality and structure of the N-end rule.
Gonda DK, Bachmair A, Wünning I, Tobias JW, Lane WS, Varshavsky A. Gonda DK, et al. Among authors: bachmair a. J Biol Chem. 1989 Oct 5;264(28):16700-12. J Biol Chem. 1989. PMID: 2506181
Our previous work has shown that, in the yeast Saccharomyces cerevisiae, any of the eight stabilizing amino-terminal residues confers a long (greater than 20 h) half-life on a test protein beta-galactosidase (beta gal), whereas 12 destabilizing amino-terminal residu …
Our previous work has shown that, in the yeast Saccharomyces cerevisiae, any of the eight stabilizing amino-terminal residues confers a
The N-end rule of selective protein turnover: mechanistic aspects and functional implications.
Varshavsky A, Bachmair A, Finley D. Varshavsky A, et al. Among authors: bachmair a. Biochem Soc Trans. 1987 Oct;15(5):815-6. doi: 10.1042/bst0150815. Biochem Soc Trans. 1987. PMID: 3691950 No abstract available.
The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Gibbs DJ, Bacardit J, Bachmair A, Holdsworth MJ. Gibbs DJ, et al. Among authors: bachmair a. Trends Cell Biol. 2014 Oct;24(10):603-11. doi: 10.1016/j.tcb.2014.05.001. Epub 2014 May 26. Trends Cell Biol. 2014. PMID: 24874449 Review.
The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the nature of its N-terminus, has emerged as a key regulator of diverse processes in eukaryotes. Recent reports that N-terminally acetylated and methionine-initiating protein …
The N-end rule pathway of targeted proteolysis, which relates the stability of a protein to the nature of its N-terminus, has emerged …
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