Bacillus subtilis antibiotics: structures, syntheses and specific functions.
Mol Microbiol. 2005.
PMID: 15853875
Review.
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Bacillus subtilis antibiotics: structures, syntheses and specific functions.
Mol Microbiol. 2005 May;56(4):845-57. doi: 10.1111/j.1365-2958.2005.04587.x.
Mol Microbiol. 2005.
PMID: 15853875
Free article.
Review.
The endospore-forming rhizobacterium Bacillus subtilis- the model system for Gram-positive organisms, is able to produce more than two dozen antibiotics with an amazing variety of structures. ...Here I summarize the structures of all known B. …
The endospore-forming rhizobacterium Bacillus subtilis- the model system for Gram-positive organisms, is able to produce more …
Probing the growth and mechanical properties of Bacillus subtilis biofilms through genetic mutation strategies.
Synth Syst Biotechnol. 2022 Jun 3;7(3):965-971. doi: 10.1016/j.synbio.2022.05.005. eCollection 2022 Sep.
Synth Syst Biotechnol. 2022.
PMID: 35756965
Free PMC article.
Bacillus subtilis is a widely used experimental species, and its biofilms are used as representative models of beneficial biofilms. ...These materials, which form an interconnected, cohesive, three-dimensional polymer network, provide the mechanical stability of bio …
Bacillus subtilis is a widely used experimental species, and its biofilms are used as representative models of beneficial biof …
Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli.
ACS Chem Biol. 2018 Oct 19;13(10):2966-2972. doi: 10.1021/acschembio.8b00599. Epub 2018 Sep 18.
ACS Chem Biol. 2018.
PMID: 30183259
Free PMC article.
Glycocins (glycosylated bacteriocins) are a family of ribosomally synthesized and post-translationally modified peptides with antimicrobial activities against pathogens of interest, including methicillin-resistant Staphylococcus aureus, representing a promising source of n …
Glycocins (glycosylated bacteriocins) are a family of ribosomally synthesized and post-translationally modified peptides with antimic …
Antibacterial Performance of Copper-loaded Mesoporous C3N6.
Small. 2026 Mar;22(13):e13990. doi: 10.1002/smll.202513990. Epub 2026 Jan 12.
Small. 2026.
PMID: 41524655
Copper-loaded mesoporous nitrogen-rich carbon nitride (xCu-mC(3)N(6)) was synthesized using a mesoporous silica SBA-15 hard template. While low-angle XRD data and transmission electron microscopic images confirm the periodic hexagonal porous texture of the synthesized …
Copper-loaded mesoporous nitrogen-rich carbon nitride (xCu-mC(3)N(6)) was synthesized using a mesoporous silica SBA-15 hard template. …
Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis.
Acta Crystallogr F Struct Biol Commun. 2024 Sep 1;80(Pt 9):200-209. doi: 10.1107/S2053230X24007039. Epub 2024 Aug 23.
Acta Crystallogr F Struct Biol Commun. 2024.
PMID: 39177700
Free PMC article.
The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as a promising candidate for the development of novel antibiotics. To identify crystals suitable for fragment screening, CdaA enzymes f …
The enzyme CdaA, which synthesizes an essential second messenger cyclic di-AMP (c-di-AMP) in many pathogenic bacteria, has emerged as …
Biosynthesis of Antimicrobial Ornithine-Containing Lacticin 481 Analogues by Use of a Combinatorial Biosynthetic Pathway in Escherichia coli.
ACS Synth Biol. 2024 Dec 20;13(12):4209-4217. doi: 10.1021/acssynbio.4c00650. Epub 2024 Dec 11.
ACS Synth Biol. 2024.
PMID: 39660664
Free PMC article.
Lacticin 481, a ribosomally synthesized and post-translationally modified peptide (RiPP), exhibits antimicrobial activity, for which its characteristic lanthionine and methyllanthionine ring structures are essential. ...Furthermore, this study demonstrates that prio …
Lacticin 481, a ribosomally synthesized and post-translationally modified peptide (RiPP), exhibits antimicrobial activity, for which …
Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.
Protein Sci. 2012 May;21(5):707-16. doi: 10.1002/pro.2058. Epub 2012 Mar 30.
Protein Sci. 2012.
PMID: 22407814
Free PMC article.
BacD is an ATP-dependent dipeptide ligase responsible for the biosynthesis of L-alanyl-L-anticapsin, a precursor of an antibiotic produced by Bacillus spp. In contrast to the well-studied and phylogenetically related D-alanine: D-alanine ligase (Ddl), BacD synthe …
BacD is an ATP-dependent dipeptide ligase responsible for the biosynthesis of L-alanyl-L-anticapsin, a precursor of an antibiotic pro …
Efficient Synthesis, Structural Characterization, Antibacterial Assessment, ADME-Tox Analysis, Molecular Docking and Molecular Dynamics Simulations of New Functionalized Isoxazoles.
Molecules. 2024 Jul 17;29(14):3366. doi: 10.3390/molecules29143366.
Molecules. 2024.
PMID: 39064944
Free PMC article.
The antibacterial effect of the isoxazoles was assessed in vitro against Escherichia coli, Bacillus subtilis, and Staphylococcusaureus bacterial strains. Isoxazole 4a showed significant activity against E. coli and B. subtilis compared to the reference ant …
The antibacterial effect of the isoxazoles was assessed in vitro against Escherichia coli, Bacillus subtilis, and Staphylococc …
Screen for agents that induce autolysis in Bacillus subtilis.
Antimicrob Agents Chemother. 2013 Jan;57(1):229-34. doi: 10.1128/AAC.00741-12. Epub 2012 Oct 22.
Antimicrob Agents Chemother. 2013.
PMID: 23089762
Free PMC article.
The growing prevalence of antibiotic-resistant infections underscores the need to discover new antibiotics and to use them with maximum effectiveness. In response to these needs, we describe a screening protocol for the discovery of autolysis-inducing agents …
The growing prevalence of antibiotic-resistant infections underscores the need to discover new antibiotics and to use them wit …
Analysis of genes involved in biosynthesis of the lantibiotic subtilin.
Appl Environ Microbiol. 1992 Jan;58(1):132-42. doi: 10.1128/aem.58.1.132-142.1992.
Appl Environ Microbiol. 1992.
PMID: 1539969
Free PMC article.
Lantibiotics are peptide-derived antibiotics with high antimicrobial activity against pathogenic gram-positive bacteria. They are ribosomally synthesized and posttranslationally modified (N. ...The most important lantibiotics are subtilin and the food preservative n …
Lantibiotics are peptide-derived antibiotics with high antimicrobial activity against pathogenic gram-positive bacteria. They are rib …
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