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Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application.
Ács N, Holohan R, Dunne LJ, Fernandes AR, Clooney AG, Draper LA, Ross RP, Hill C. Ács N, et al. Among authors: hill c. Viruses. 2022 Nov 25;14(12):2632. doi: 10.3390/v14122632. Viruses. 2022. PMID: 36560636 Free PMC article.
Less studied components of the gut microbiome are the bacterial viruses called bacteriophages that may be present in numbers equal to or greater than the prokaryotes. ...This knowledge can guide us to a better understanding of the short-term impact of bacteriophage …
Less studied components of the gut microbiome are the bacterial viruses called bacteriophages that may be present in numbers equal to …
The gut virome in health and disease: new insights and associations.
Shareefdeen H, Hill C. Shareefdeen H, et al. Among authors: hill c. Curr Opin Gastroenterol. 2022 Nov 1;38(6):549-554. doi: 10.1097/MOG.0000000000000885. Epub 2022 Sep 9. Curr Opin Gastroenterol. 2022. PMID: 36165045 Review.
The vast majority of the human intestinal virome consists of bacteriophages, viruses that infect bacteria. The dynamic relationship between gut bacterial populations and bacteriophages is influenced by environmental factors that also impact host health and disease. …
The vast majority of the human intestinal virome consists of bacteriophages, viruses that infect bacteria. The dynamic relationship b …
Impact of a phage cocktail targeting Escherichia coli and Enterococcus faecalis as members of a gut bacterial consortium in vitro and in vivo.
Buttimer C, Sutton T, Colom J, Murray E, Bettio PH, Smith L, Bolocan AS, Shkoporov A, Oka A, Liu B, Herzog JW, Sartor RB, Draper LA, Ross RP, Hill C. Buttimer C, et al. Among authors: hill c. Front Microbiol. 2022 Jul 22;13:936083. doi: 10.3389/fmicb.2022.936083. eCollection 2022. Front Microbiol. 2022. PMID: 35935217 Free PMC article.
Escherichia coli and Enterococcus faecalis have been implicated as important players in human gut health that have been associated with the onset of inflammatory bowel disease (IBD). Bacteriophage (phage) therapy has been used for decades to target pathogens as an alternat …
Escherichia coli and Enterococcus faecalis have been implicated as important players in human gut health that have been associated with the …
Viral biogeography of the mammalian gut and parenchymal organs.
Shkoporov AN, Stockdale SR, Lavelle A, Kondova I, Heuston C, Upadrasta A, Khokhlova EV, van der Kamp I, Ouwerling B, Draper LA, Langermans JAM, Paul Ross R, Hill C. Shkoporov AN, et al. Among authors: hill c. Nat Microbiol. 2022 Aug;7(8):1301-1311. doi: 10.1038/s41564-022-01178-w. Epub 2022 Aug 2. Nat Microbiol. 2022. PMID: 35918425 Free PMC article.
Luminal samples from the large intestine of both mammals harboured the highest loads and diversity of bacteriophages (class Caudoviricetes, family Microviridae and others). Mucosal samples contained much lower viral loads but a higher proportion of eukaryotic viruses (fami …
Luminal samples from the large intestine of both mammals harboured the highest loads and diversity of bacteriophages (class Caudoviri …
Mutualistic interplay between bacteriophages and bacteria in the human gut.
Shkoporov AN, Turkington CJ, Hill C. Shkoporov AN, et al. Among authors: hill c. Nat Rev Microbiol. 2022 Dec;20(12):737-749. doi: 10.1038/s41579-022-00755-4. Epub 2022 Jun 30. Nat Rev Microbiol. 2022. PMID: 35773472 Review.
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts, and phage predation is one of the leading forces controlling the density and distribution of bacterial populations. ...
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts, and phage predation is one of the leading …
Phage-mediated horizontal gene transfer and its implications for the human gut microbiome.
Borodovich T, Shkoporov AN, Ross RP, Hill C. Borodovich T, et al. Among authors: hill c. Gastroenterol Rep (Oxf). 2022 Apr 13;10:goac012. doi: 10.1093/gastro/goac012. eCollection 2022. Gastroenterol Rep (Oxf). 2022. PMID: 35425613 Free PMC article.
Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacteriophage transfers non-viral DNA from one bacterial host cell to another. The abundance of tailed bacteriophages in the human gut …
Evidence exists of extensive horizontal transfer in the human gut microbiome. Phage transduction is a type of HGT event in which a bacter …
Insights into Gene Transcriptional Regulation of Kayvirus Bacteriophages Obtained from Therapeutic Mixtures.
Arroyo-Moreno S, Buttimer C, Bottacini F, Chanishvili N, Ross P, Hill C, Coffey A. Arroyo-Moreno S, et al. Among authors: hill c. Viruses. 2022 Mar 17;14(3):626. doi: 10.3390/v14030626. Viruses. 2022. PMID: 35337034 Free PMC article.
Bacteriophages (phages) of the genus Kayvirus of Staphylococcus aureus are promising agents for therapeutic applications. ...
Bacteriophages (phages) of the genus Kayvirus of Staphylococcus aureus are promising agents for therapeutic applications. ...
Selective Isolation of Eggerthella lenta from Human Faeces and Characterisation of the Species Prophage Diversity.
Buttimer C, Bottacini F, Shkoporov AN, Draper LA, Ross P, Hill C. Buttimer C, et al. Among authors: hill c. Microorganisms. 2022 Jan 17;10(1):195. doi: 10.3390/microorganisms10010195. Microorganisms. 2022. PMID: 35056644 Free PMC article.
However, little is known regarding its susceptibility to bacteriophage predation and how this may influence its fitness. Here, we report the isolation of seven novel E. lenta strains using cefotaxime and ceftriaxone as selective agents. ...Prophage gene products represent …
However, little is known regarding its susceptibility to bacteriophage predation and how this may influence its fitness. Here, we rep …
Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis.
Shkoporov AN, Khokhlova EV, Stephens N, Hueston C, Seymour S, Hryckowian AJ, Scholz D, Ross RP, Hill C. Shkoporov AN, et al. Among authors: hill c. BMC Biol. 2021 Aug 18;19(1):163. doi: 10.1186/s12915-021-01084-3. BMC Biol. 2021. PMID: 34407825 Free PMC article.
From an ecological and evolutionary standpoint, this type of phage-host interaction is consistent with the Piggyback-the-Winner model, which suggests a preference towards lysogenic or other "benign" forms of phage infection when the host is stably present at high abundance. CONCL …
From an ecological and evolutionary standpoint, this type of phage-host interaction is consistent with the Piggyback-the-Winner model, which …
Characterization of an Endolysin Targeting Clostridioides difficile That Affects Spore Outgrowth.
Mondal SI, Akter A, Draper LA, Ross RP, Hill C. Mondal SI, et al. Among authors: hill c. Int J Mol Sci. 2021 May 26;22(11):5690. doi: 10.3390/ijms22115690. Int J Mol Sci. 2021. PMID: 34073633 Free PMC article.
Therefore, there is an urgent need for novel therapeutics that are effective in preventing C. difficile growth, spore germination, and outgrowth. In recent years bacteriophage-derived endolysins and their derivatives show promise as a novel class of antibacterial agents. . …
Therefore, there is an urgent need for novel therapeutics that are effective in preventing C. difficile growth, spore germination, and outgr …
Stability of the human gut virome and effect of gluten-free diet.
Garmaeva S, Gulyaeva A, Sinha T, Shkoporov AN, Clooney AG, Stockdale SR, Spreckels JE, Sutton TDS, Draper LA, Dutilh BE, Wijmenga C, Kurilshikov A, Fu J, Hill C, Zhernakova A. Garmaeva S, et al. Among authors: hill c. Cell Rep. 2021 May 18;35(7):109132. doi: 10.1016/j.celrep.2021.109132. Cell Rep. 2021. PMID: 34010651 Free article.
Efficacy of Phage- and Bacteriocin-Based Therapies in Combatting Nosocomial MRSA Infections.
Walsh L, Johnson CN, Hill C, Ross RP. Walsh L, et al. Among authors: hill c. Front Mol Biosci. 2021 Apr 29;8:654038. doi: 10.3389/fmolb.2021.654038. eCollection 2021. Front Mol Biosci. 2021. PMID: 33996906 Free PMC article. Review.
Although antibiotics are available to treat nosocomial infections, the increased occurrence of antibiotic resistance has rendered many treatments ineffective. Such is the case for methicillin resistant S. aureus (MRSA), which has continued to be a threat to public health s …
Although antibiotics are available to treat nosocomial infections, the increased occurrence of antibiotic resistance has rendered many treat …
The Advantages and Challenges of Using Endolysins in a Clinical Setting.
Murray E, Draper LA, Ross RP, Hill C. Murray E, et al. Among authors: hill c. Viruses. 2021 Apr 15;13(4):680. doi: 10.3390/v13040680. Viruses. 2021. PMID: 33920965 Free PMC article. Review.
Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. Bacteriophage-derived proteins such as endolysins could offer one effective solution. Endolysins are bacteriophage-encoded pep …
Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. …
Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens.
Guerin E, Shkoporov AN, Stockdale SR, Comas JC, Khokhlova EV, Clooney AG, Daly KM, Draper LA, Stephens N, Scholz D, Ross RP, Hill C. Guerin E, et al. Among authors: hill c. Microbiome. 2021 Apr 12;9(1):89. doi: 10.1186/s40168-021-01036-7. Microbiome. 2021. PMID: 33845877 Free PMC article.
BACKGROUND: The gut phageome comprises a complex phage community of thousands of individual strains, with a few highly abundant bacteriophages. CrAss-like phages, which infect bacteria of the order Bacteroidales, are the most abundant bacteriophage family in the hum …
BACKGROUND: The gut phageome comprises a complex phage community of thousands of individual strains, with a few highly abundant bacteriop …
Probing the "Dark Matter" of the Human Gut Phageome: Culture Assisted Metagenomics Enables Rapid Discovery and Host-Linking for Novel Bacteriophages.
Fitzgerald CB, Shkoporov AN, Upadrasta A, Khokhlova EV, Ross RP, Hill C. Fitzgerald CB, et al. Among authors: hill c. Front Cell Infect Microbiol. 2021 Mar 15;11:616918. doi: 10.3389/fcimb.2021.616918. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 33791236 Free PMC article.
Recent years have been marked by the growing interest towards virulent and temperate bacteriophage populations inhabiting the human lower gastrointestinal tract - the gut phageome. ...Using this approach dozens of novel and previously known bacteriophages were detec …
Recent years have been marked by the growing interest towards virulent and temperate bacteriophage populations inhabiting the human l …
A New Phage Lysin Isolated from the Oral Microbiome Targeting Streptococcus pneumoniae.
van der Kamp I, Draper LA, Smith MK, Buttimer C, Ross RP, Hill C. van der Kamp I, et al. Among authors: hill c. Pharmaceuticals (Basel). 2020 Dec 19;13(12):478. doi: 10.3390/ph13120478. Pharmaceuticals (Basel). 2020. PMID: 33352708 Free PMC article.
Due to the rising number of multidrug-resistant (MDR) strains of S. pneumoniae, new antimicrobials with alternative mechanisms of action are urgently needed. ...Their lysins, 23TH_48 and SA01_53, were recombinantly expressed, characterized and tested for their lethality. S …
Due to the rising number of multidrug-resistant (MDR) strains of S. pneumoniae, new antimicrobials with alternative mechanisms of act …
Autochthonous faecal viral transfer (FVT) impacts the murine microbiome after antibiotic perturbation.
Draper LA, Ryan FJ, Dalmasso M, Casey PG, McCann A, Velayudhan V, Ross RP, Hill C. Draper LA, et al. Among authors: hill c. BMC Biol. 2020 Nov 20;18(1):173. doi: 10.1186/s12915-020-00906-0. BMC Biol. 2020. PMID: 33218339 Free PMC article.
However, the bacteriomes of mice that received an FVT, in which bacteriophages predominate, separated from those of the control mice as determined by principal co-ordinate analysis (PCoA). ...Similarly, metagenomic sequencing of the virome confirmed that faecal bacterio …
However, the bacteriomes of mice that received an FVT, in which bacteriophages predominate, separated from those of the control mice …
Shining Light on Human Gut Bacteriophages.
Guerin E, Hill C. Guerin E, et al. Among authors: hill c. Front Cell Infect Microbiol. 2020 Sep 10;10:481. doi: 10.3389/fcimb.2020.00481. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 33014897 Free PMC article. Review.
Multiple factors have a role to play in driving the composition of human gut bacterial communities either toward homeostasis or the instability that is associated with many disease states. One of the most important forces are likely to be bacteriophages, bacteria-infecting …
Multiple factors have a role to play in driving the composition of human gut bacterial communities either toward homeostasis or the instabil …
62 results