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Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages.
Cortés-Martín A, Buttimer C, Maier JL, Tobin CA, Draper LA, Ross RP, Kleiner M, Hill C, Shkoporov AN. Cortés-Martín A, et al. Among authors: draper la. Gut Microbes. 2025 Dec;17(1):2507775. doi: 10.1080/19490976.2025.2507775. Epub 2025 May 23. Gut Microbes. 2025. PMID: 40407098 Free PMC article.
Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. ...
Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. ...
Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages.
Cortés-Martín A, Buttimer C, Maier JL, Tobin CA, Draper LA, Ross RP, Kleiner M, Hill C, Shkoporov AN. Cortés-Martín A, et al. Among authors: draper la. bioRxiv [Preprint]. 2024 Nov 17:2024.11.17.624012. doi: 10.1101/2024.11.17.624012. bioRxiv. 2024. Update in: Gut Microbes. 2025 Dec;17(1):2507775. doi: 10.1080/19490976.2025.2507775. PMID: 39605433 Free PMC article. Updated. Preprint.
BACKGROUND: Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. ...
BACKGROUND: Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. ...
Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis.
Khan T, Mondal SI, Mahmud A, Karim D, Draper LA, Hill C, Azad AK, Akter A. Khan T, et al. Among authors: draper la. Biochem Biophys Rep. 2024 Oct 14;40:101844. doi: 10.1016/j.bbrep.2024.101844. eCollection 2024 Dec. Biochem Biophys Rep. 2024. PMID: 39483175 Free PMC article.
Identifying alternatives to antibiotic therapies is urgently needed to combat Pneumococcus. Bacteriophage-derived endolysins can be used as alternative therapeutics due to their bacterial cell wall hydrolyzing capability. ...
Identifying alternatives to antibiotic therapies is urgently needed to combat Pneumococcus. Bacteriophage-derived endolysins can be u …
Isolation and characterization of Septuagintavirus; a novel clade of Escherichia coli phages within the subfamily Vequintavirinae.
Cortés-Martín A, Buttimer C, Pozhydaieva N, Hille F, Shareefdeen H, Bolocan AS, Draper LA, Shkoporov AN, Franz CMAP, Höfer K, Ross RP, Hill C. Cortés-Martín A, et al. Among authors: draper la. Microbiol Spectr. 2024 Sep 3;12(9):e0059224. doi: 10.1128/spectrum.00592-24. Epub 2024 Aug 5. Microbiol Spectr. 2024. PMID: 39101714 Free PMC article.
There is increasing interest in comprehending the variety of bacteriophages (phages) that target this bacterium, as such insights could pave the way for their potential use in therapeutic applications. ...Certain strains are associated with gastrointestinal diseases, and t …
There is increasing interest in comprehending the variety of bacteriophages (phages) that target this bacterium, as such insights cou …
The gut virome is associated with stress-induced changes in behaviour and immune responses in mice.
Ritz NL, Draper LA, Bastiaanssen TFS, Turkington CJR, Peterson VL, van de Wouw M, Vlckova K, Fülling C, Guzzetta KE, Burokas A, Harris H, Dalmasso M, Crispie F, Cotter PD, Shkoporov AN, Moloney GM, Dinan TG, Hill C, Cryan JF. Ritz NL, et al. Among authors: draper la. Nat Microbiol. 2024 Feb;9(2):359-376. doi: 10.1038/s41564-023-01564-y. Epub 2024 Feb 5. Nat Microbiol. 2024. PMID: 38316929 Free PMC article.
The gut virome constitutes a major portion of the microbiome, with bacteriophages having the potential to remodel bacteriome structure and activity. Here we use a mouse model of chronic social stress, and employ 16S rRNA and whole metagenomic sequencing on faecal pellets t …
The gut virome constitutes a major portion of the microbiome, with bacteriophages having the potential to remodel bacteriome structur …
Dynamic nature of viral and bacterial communities in human faeces.
Shkoporov AN, O'Regan O, Smith L, Khokhlova EV, Draper LA, Ross RP, Hill C. Shkoporov AN, et al. Among authors: draper la. iScience. 2023 Dec 29;27(2):108778. doi: 10.1016/j.isci.2023.108778. eCollection 2024 Feb 16. iScience. 2023. PMID: 38292428 Free PMC article.
Bacteriophages are a major component of the gut microbiome and are believed to play a role in establishment and stabilization of microbial communities by influencing taxonomic and functional diversity. ...We observed subject-specific blooms and collapses of selected bac …
Bacteriophages are a major component of the gut microbiome and are believed to play a role in establishment and stabilization of micr …
Isolation and characterization of a novel lytic Parabacteroides distasonis bacteriophage phiPDS1 from the human gut.
Cortés-Martín A, Denise R, Guerin E, Stockdale SR, Draper LA, Ross RP, Shkoporov AN, Hill C. Cortés-Martín A, et al. Among authors: draper la. Gut Microbes. 2024 Jan-Dec;16(1):2298254. doi: 10.1080/19490976.2023.2298254. Epub 2024 Jan 4. Gut Microbes. 2024. PMID: 38178369 Free PMC article.
The viral component (virome) is predominantly composed of bacteriophages (phages) and has received significantly less attention in comparison to the bacteriome. ...
The viral component (virome) is predominantly composed of bacteriophages (phages) and has received significantly less attention in co …
Temperate bacteriophages infecting the mucin-degrading bacterium Ruminococcus gnavus from the human gut.
Buttimer C, Khokhlova EV, Stein L, Hueston CM, Govi B, Draper LA, Ross RP, Shkoporov AN, Hill C. Buttimer C, et al. Among authors: draper la. Gut Microbes. 2023 Jan-Dec;15(1):2194794. doi: 10.1080/19490976.2023.2194794. Gut Microbes. 2023. PMID: 36994608 Free PMC article.
This study reports the isolation and characterization of six bacteriophages (phages) isolated from human fecal material and environmental samples that infect this species. ...
This study reports the isolation and characterization of six bacteriophages (phages) isolated from human fecal material and environme …
Comparing In Vitro Faecal Fermentation Methods as Surrogates for Phage Therapy Application.
Ács N, Holohan R, Dunne LJ, Fernandes AR, Clooney AG, Draper LA, Ross RP, Hill C. Ács N, et al. Among authors: draper la. Viruses. 2022 Nov 25;14(12):2632. doi: 10.3390/v14122632. Viruses. 2022. PMID: 36560636 Free PMC article.
Less studied components of the gut microbiome are the bacterial viruses called bacteriophages that may be present in numbers equal to or greater than the prokaryotes. Their potential to lyse their bacterial hosts, or to act as agents of horizontal gene transfer makes them …
Less studied components of the gut microbiome are the bacterial viruses called bacteriophages that may be present in numbers equal to …
Impact of a phage cocktail targeting Escherichia coli and Enterococcus faecalis as members of a gut bacterial consortium in vitro and in vivo.
Buttimer C, Sutton T, Colom J, Murray E, Bettio PH, Smith L, Bolocan AS, Shkoporov A, Oka A, Liu B, Herzog JW, Sartor RB, Draper LA, Ross RP, Hill C. Buttimer C, et al. Among authors: draper la. Front Microbiol. 2022 Jul 22;13:936083. doi: 10.3389/fmicb.2022.936083. eCollection 2022. Front Microbiol. 2022. PMID: 35935217 Free PMC article.
Escherichia coli and Enterococcus faecalis have been implicated as important players in human gut health that have been associated with the onset of inflammatory bowel disease (IBD). Bacteriophage (phage) therapy has been used for decades to target pathogens as an alternat …
Escherichia coli and Enterococcus faecalis have been implicated as important players in human gut health that have been associated with the …
Viral biogeography of the mammalian gut and parenchymal organs.
Shkoporov AN, Stockdale SR, Lavelle A, Kondova I, Heuston C, Upadrasta A, Khokhlova EV, van der Kamp I, Ouwerling B, Draper LA, Langermans JAM, Paul Ross R, Hill C. Shkoporov AN, et al. Among authors: draper la. Nat Microbiol. 2022 Aug;7(8):1301-1311. doi: 10.1038/s41564-022-01178-w. Epub 2022 Aug 2. Nat Microbiol. 2022. PMID: 35918425 Free PMC article.
Luminal samples from the large intestine of both mammals harboured the highest loads and diversity of bacteriophages (class Caudoviricetes, family Microviridae and others). Mucosal samples contained much lower viral loads but a higher proportion of eukaryotic viruses (fami …
Luminal samples from the large intestine of both mammals harboured the highest loads and diversity of bacteriophages (class Caudoviri …
Selective Isolation of Eggerthella lenta from Human Faeces and Characterisation of the Species Prophage Diversity.
Buttimer C, Bottacini F, Shkoporov AN, Draper LA, Ross P, Hill C. Buttimer C, et al. Among authors: draper la. Microorganisms. 2022 Jan 17;10(1):195. doi: 10.3390/microorganisms10010195. Microorganisms. 2022. PMID: 35056644 Free PMC article.
However, little is known regarding its susceptibility to bacteriophage predation and how this may influence its fitness. Here, we report the isolation of seven novel E. lenta strains using cefotaxime and ceftriaxone as selective agents. ...Prophage gene products represent …
However, little is known regarding its susceptibility to bacteriophage predation and how this may influence its fitness. Here, we rep …
Characterization of an Endolysin Targeting Clostridioides difficile That Affects Spore Outgrowth.
Mondal SI, Akter A, Draper LA, Ross RP, Hill C. Mondal SI, et al. Among authors: draper la. Int J Mol Sci. 2021 May 26;22(11):5690. doi: 10.3390/ijms22115690. Int J Mol Sci. 2021. PMID: 34073633 Free PMC article.
Therefore, there is an urgent need for novel therapeutics that are effective in preventing C. difficile growth, spore germination, and outgrowth. In recent years bacteriophage-derived endolysins and their derivatives show promise as a novel class of antibacterial agents. . …
Therefore, there is an urgent need for novel therapeutics that are effective in preventing C. difficile growth, spore germination, and outgr …
Stability of the human gut virome and effect of gluten-free diet.
Garmaeva S, Gulyaeva A, Sinha T, Shkoporov AN, Clooney AG, Stockdale SR, Spreckels JE, Sutton TDS, Draper LA, Dutilh BE, Wijmenga C, Kurilshikov A, Fu J, Hill C, Zhernakova A. Garmaeva S, et al. Among authors: draper la. Cell Rep. 2021 May 18;35(7):109132. doi: 10.1016/j.celrep.2021.109132. Cell Rep. 2021. PMID: 34010651 Free article.
The Advantages and Challenges of Using Endolysins in a Clinical Setting.
Murray E, Draper LA, Ross RP, Hill C. Murray E, et al. Among authors: draper la. Viruses. 2021 Apr 15;13(4):680. doi: 10.3390/v13040680. Viruses. 2021. PMID: 33920965 Free PMC article. Review.
Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. Bacteriophage-derived proteins such as endolysins could offer one effective solution. Endolysins are bacteriophage-encoded pep …
Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed. …
Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens.
Guerin E, Shkoporov AN, Stockdale SR, Comas JC, Khokhlova EV, Clooney AG, Daly KM, Draper LA, Stephens N, Scholz D, Ross RP, Hill C. Guerin E, et al. Among authors: draper la. Microbiome. 2021 Apr 12;9(1):89. doi: 10.1186/s40168-021-01036-7. Microbiome. 2021. PMID: 33845877 Free PMC article.
BACKGROUND: The gut phageome comprises a complex phage community of thousands of individual strains, with a few highly abundant bacteriophages. CrAss-like phages, which infect bacteria of the order Bacteroidales, are the most abundant bacteriophage family in the hum …
BACKGROUND: The gut phageome comprises a complex phage community of thousands of individual strains, with a few highly abundant bacteriop …
Autochthonous faecal viral transfer (FVT) impacts the murine microbiome after antibiotic perturbation.
Draper LA, Ryan FJ, Dalmasso M, Casey PG, McCann A, Velayudhan V, Ross RP, Hill C. Draper LA, et al. BMC Biol. 2020 Nov 20;18(1):173. doi: 10.1186/s12915-020-00906-0. BMC Biol. 2020. PMID: 33218339 Free PMC article.
However, the bacteriomes of mice that received an FVT, in which bacteriophages predominate, separated from those of the control mice as determined by principal co-ordinate analysis (PCoA). ...Similarly, metagenomic sequencing of the virome confirmed that faecal bacterio …
However, the bacteriomes of mice that received an FVT, in which bacteriophages predominate, separated from those of the control mice …
Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection.
Mondal SI, Draper LA, Ross RP, Hill C. Mondal SI, et al. Among authors: draper la. Gut Microbes. 2020 Nov 9;12(1):1813533. doi: 10.1080/19490976.2020.1813533. Gut Microbes. 2020. PMID: 32985336 Free PMC article. Review.
Novel targeted therapeutics are urgently needed to combat CDI. Bacteriophage-derived endolysins are required to disrupt the bacterial cell wall of their target bacteria and are possible alternatives to antibiotics. ...
Novel targeted therapeutics are urgently needed to combat CDI. Bacteriophage-derived endolysins are required to disrupt the bacterial …
30 results