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Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.
Woo JH, Kim YH, Choi YJ, Kim DG, Lee KS, Bae JH, Min DS, Chang JS, Jeong YJ, Lee YH, Park JW, Kwon TK. Woo JH, et al. Among authors: bae jh. Carcinogenesis. 2003 Jul;24(7):1199-208. doi: 10.1093/carcin/bgg082. Epub 2003 May 9. Carcinogenesis. 2003. PMID: 12807727
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.
Jang BC, Paik JH, Jeong HY, Oh HJ, Park JW, Kwon TK, Song DK, Park JG, Kim SP, Bae JH, Mun KC, Suh MH, Yoshida M, Suh SI. Jang BC, et al. Among authors: bae jh. Biochem Pharmacol. 2004 Jul 15;68(2):263-74. doi: 10.1016/j.bcp.2004.03.007. Biochem Pharmacol. 2004. PMID: 15193998
1,513 results