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Low doses of anti-CD3, ciclosporin A and the vitamin D analogue, TX527, synergise to delay recurrence of autoimmune diabetes in an islet-transplanted NOD mouse model of diabetes.
Baeke F, Van Belle TL, Takiishi T, Ding L, Korf H, Laureys J, Gysemans C, Mathieu C. Baeke F, et al. Diabetologia. 2012 Oct;55(10):2723-2732. doi: 10.1007/s00125-012-2630-1. Epub 2012 Jul 3. Diabetologia. 2012. PMID: 22752077
A proteomic approach on the effects of TX527, a 1α,25-dihydroxyvitamin D3 analog, in human T lymphocytes.
Ferreira GB, Baeke F, Verstuyf A, De Clercq P, Waelkens E, Mathieu C, Overbergh L. Ferreira GB, et al. Among authors: baeke f. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:96-101. doi: 10.1016/j.jsbmb.2013.10.013. Epub 2013 Oct 28. J Steroid Biochem Mol Biol. 2014. PMID: 24176759
The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, Van Lommel L, Waer M, Schuit F, Gysemans C, Mathieu C. Baeke F, et al. J Immunol. 2011 Jan 1;186(1):132-42. doi: 10.4049/jimmunol.1000695. Epub 2010 Dec 3. J Immunol. 2011. PMID: 21131424 Free article.
Vitamin D: modulator of the immune system.
Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Baeke F, et al. Curr Opin Pharmacol. 2010 Aug;10(4):482-96. doi: 10.1016/j.coph.2010.04.001. Epub 2010 Apr 27. Curr Opin Pharmacol. 2010. PMID: 20427238 Review.
Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system.
Baeke F, Korf H, Overbergh L, van Etten E, Verstuyf A, Gysemans C, Mathieu C. Baeke F, et al. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):221-7. doi: 10.1016/j.jsbmb.2010.03.037. Epub 2010 Mar 17. J Steroid Biochem Mol Biol. 2010. PMID: 20302932
Vitamin D insufficiency: implications for the immune system.
Baeke F, Gysemans C, Korf H, Mathieu C. Baeke F, et al. Pediatr Nephrol. 2010 Sep;25(9):1597-606. doi: 10.1007/s00467-010-1452-y. Epub 2010 Feb 24. Pediatr Nephrol. 2010. PMID: 20180136 Review.
Vitamin D3 and the immune system: maintaining the balance in health and disease.
Baeke F, Etten EV, Overbergh L, Mathieu C. Baeke F, et al. Nutr Res Rev. 2007 Jun;20(1):106-18. doi: 10.1017/S0954422407742713. Nutr Res Rev. 2007. PMID: 19079863
High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.
Lehouck A, Mathieu C, Carremans C, Baeke F, Verhaegen J, Van Eldere J, Decallonne B, Bouillon R, Decramer M, Janssens W. Lehouck A, et al. Among authors: baeke f. Ann Intern Med. 2012 Jan 17;156(2):105-14. doi: 10.7326/0003-4819-156-2-201201170-00004. Ann Intern Med. 2012. PMID: 22250141 Clinical Trial.
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Takiishi T, Ding L, Baeke F, Spagnuolo I, Sebastiani G, Laureys J, Verstuyf A, Carmeliet G, Dotta F, Van Belle TL, Gysemans CA, Mathieu C. Takiishi T, et al. Among authors: baeke f. Diabetes. 2014 Jun;63(6):2026-36. doi: 10.2337/db13-1559. Epub 2014 Feb 18. Diabetes. 2014. PMID: 24550187 Free article.
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