Baer RJ - Search Results

1

Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.

Chiang HC, Zhang X, Zhao X, Zhang C, Chen J, Garza P, Smith S, Ludwig T, Baer RJ, Li R, Hu Y. Chiang HC, et al. Among authors: baer rj. Sci Rep. 2018 Feb 9;8(1):2731. doi: 10.1038/s41598-018-21044-2. Sci Rep. 2018. PMID: 29426838 Free PMC article.

2

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

Baer R, Ludwig T. Baer R, et al. Curr Opin Genet Dev. 2002 Feb;12(1):86-91. doi: 10.1016/s0959-437x(01)00269-6. Curr Opin Genet Dev. 2002. PMID: 11790560 Review.

3

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T. Shakya R, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28. Proc Natl Acad Sci U S A. 2008. PMID: 18443292 Free PMC article.

4

The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. Reczek CR, et al. Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605. Oncotarget. 2016. PMID: 27058754 Free PMC article.

5

53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1.

Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. Li M, et al. EMBO Rep. 2016 Nov;17(11):1532-1541. doi: 10.15252/embr.201642497. Epub 2016 Sep 26. EMBO Rep. 2016. PMID: 27670884 Free PMC article.

6

Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.

Laufer M, Nandula SV, Modi AP, Wang S, Jasin M, Murty VV, Ludwig T, Baer R. Laufer M, et al. J Biol Chem. 2007 Nov 23;282(47):34325-33. doi: 10.1074/jbc.M705198200. Epub 2007 Sep 11. J Biol Chem. 2007. PMID: 17848578 Free article.

7

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T. Reid LJ, et al. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. doi: 10.1073/pnas.0811203106. Epub 2008 Dec 16. Proc Natl Acad Sci U S A. 2008. PMID: 19088202 Free PMC article.

8

The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.

Wu-Baer F, Ludwig T, Baer R. Wu-Baer F, et al. Mol Cell Biol. 2010 Jun;30(11):2787-98. doi: 10.1128/MCB.01056-09. Epub 2010 Mar 29. Mol Cell Biol. 2010. PMID: 20351172 Free PMC article.

9

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. Shakya R, et al. Science. 2011 Oct 28;334(6055):525-8. doi: 10.1126/science.1209909. Science. 2011. PMID: 22034435 Free PMC article.

10

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R. Reczek CR, et al. J Cell Biol. 2013 May 27;201(5):693-707. doi: 10.1083/jcb.201302145. J Cell Biol. 2013. PMID: 23712259 Free PMC article.

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