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A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration.
Krinner EM, Hepp J, Hoffmann P, Bruckmaier S, Petersen L, Petsch S, Parr L, Schuster I, Mangold S, Lorenczewski G, Lutterbüse P, Buziol S, Hochheim I, Volkland J, Mølhøj M, Sriskandarajah M, Strasser M, Itin C, Wolf A, Basu A, Yang K, Filpula D, Sørensen P, Kufer P, Baeuerle P, Raum T. Krinner EM, et al. Protein Eng Des Sel. 2006 Oct;19(10):461-70. doi: 10.1093/protein/gzl031. Epub 2006 Jul 25. Protein Eng Des Sel. 2006. PMID: 16868004
A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.
Krinner EM, Raum T, Petsch S, Bruckmaier S, Schuster I, Petersen L, Cierpka R, Abebe D, Mølhøj M, Wolf A, Sørensen P, Locher M, Baeuerle PA, Hepp J. Krinner EM, et al. Among authors: baeuerle pa. Mol Immunol. 2007 Feb;44(5):916-25. doi: 10.1016/j.molimm.2006.03.020. Epub 2006 May 11. Mol Immunol. 2007. PMID: 16697465
Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model.
Plater-Zyberk C, Joosten LA, Helsen MM, Koenders MI, Baeuerle PA, van den Berg WB. Plater-Zyberk C, et al. Among authors: baeuerle pa. Ann Rheum Dis. 2009 May;68(5):721-8. doi: 10.1136/ard.2007.085431. Epub 2008 May 21. Ann Rheum Dis. 2009. PMID: 18495731
Constitutive nuclear NF-kappa B in cells of the monocyte lineage.
Frankenberger M, Pforte A, Sternsdorf T, Passlick B, Baeuerle PA, Ziegler-Heitbrock HW. Frankenberger M, et al. Among authors: baeuerle pa. Biochem J. 1994 Nov 15;304 ( Pt 1)(Pt 1):87-94. doi: 10.1042/bj3040087. Biochem J. 1994. PMID: 7998962 Free PMC article.
247 results