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cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity.
Ferris ST, Durai V, Wu R, Theisen DJ, Ward JP, Bern MD, Davidson JT 4th, Bagadia P, Liu T, Briseño CG, Li L, Gillanders WE, Wu GF, Yokoyama WM, Murphy TL, Schreiber RD, Murphy KM. Ferris ST, et al. Among authors: bagadia p. Nature. 2020 Aug;584(7822):624-629. doi: 10.1038/s41586-020-2611-3. Epub 2020 Aug 12. Nature. 2020. PMID: 32788723 Free PMC article.
Notch2-dependent DC2s mediate splenic germinal center responses.
Briseño CG, Satpathy AT, Davidson JT 4th, Ferris ST, Durai V, Bagadia P, O'Connor KW, Theisen DJ, Murphy TL, Murphy KM. Briseño CG, et al. Among authors: bagadia p. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10726-10731. doi: 10.1073/pnas.1809925115. Epub 2018 Oct 2. Proc Natl Acad Sci U S A. 2018. PMID: 30279176 Free PMC article.
WDFY4 is required for cross-presentation in response to viral and tumor antigens.
Theisen DJ, Davidson JT 4th, Briseño CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM. Theisen DJ, et al. Among authors: bagadia p. Science. 2018 Nov 9;362(6415):694-699. doi: 10.1126/science.aat5030. Science. 2018. PMID: 30409884 Free PMC article.
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.
Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. Bagadia P, et al. Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12. Nat Immunol. 2019. PMID: 31406377 Free PMC article.
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. Durai V, et al. Among authors: bagadia p. Nat Immunol. 2019 Sep;20(9):1161-1173. doi: 10.1038/s41590-019-0450-x. Epub 2019 Aug 12. Nat Immunol. 2019. PMID: 31406378 Free PMC article.
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