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The endothelin axis: emerging role in cancer.
Nelson J, Bagnato A, Battistini B, Nisen P. Nelson J, et al. Among authors: bagnato a. Nat Rev Cancer. 2003 Feb;3(2):110-6. doi: 10.1038/nrc990. Nat Rev Cancer. 2003. PMID: 12563310 Review.
Preliminary results from clinical trials, such as those with atrasentan--an ET(A)-receptor antagonist--in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation....
Preliminary results from clinical trials, such as those with atrasentan--an ET(A)-receptor antagonist--in prostate cancer, are encour …
Identification of the ETA receptor subtype that mediates endothelin induced autocrine proliferation of normal human keratinocytes.
Bagnato A, Venuti A, Di Castro V, Marcante ML. Bagnato A, et al. Biochem Biophys Res Commun. 1995 Apr 6;209(1):80-6. doi: 10.1006/bbrc.1995.1473. Biochem Biophys Res Commun. 1995. PMID: 7726867
Endothelin-1 has a wide range of pharmacological effects in various tissues and acts as autocrine/paracrine factor. The potential of ET-1 to function as an autocrine growth factor was evaluated in normal human keratinocytes. Radioligand binding studies showed that 125I-ET- …
Endothelin-1 has a wide range of pharmacological effects in various tissues and acts as autocrine/paracrine factor. The potential of …
Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells.
Bagnato A, Tecce R, Di Castro V, Catt KJ. Bagnato A, et al. Cancer Res. 1997 Apr 1;57(7):1306-11. Cancer Res. 1997. PMID: 9102218
ET-1 also stimulated the rapid expression of c-fos, an action mediated by ET(A) receptors. The mitogenic action of ET-1 was not mediated by a pertussis toxin-sensitive G protein. ...These findings also indicate that intracellular signaling between the ET(A) r …
ET-1 also stimulated the rapid expression of c-fos, an action mediated by ET(A) receptors. The mitogenic action of ET-1 was not media …
Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth.
Bagnato A, Salani D, Di Castro V, Wu-Wong JR, Tecce R, Nicotra MR, Venuti A, Natali PG. Bagnato A, et al. Cancer Res. 1999 Feb 1;59(3):720-7. Cancer Res. 1999. PMID: 9973223
ET(A)R mRNA was also detected in 84% of the carcinomas examined, whereas ET(B)R mRNA was expressed in 50% of the tumors. The in vivo presence of mature ET-1 and ET(A)R was confirmed by immunohistochemistry, demonstrating a higher expression in primary and met …
ET(A)R mRNA was also detected in 84% of the carcinomas examined, whereas ET(B)R mRNA was expressed in 50% of the tumors. The in vivo …
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
Vacca F, Bagnato A, Catt KJ, Tecce R. Vacca F, et al. Among authors: bagnato a. Cancer Res. 2000 Sep 15;60(18):5310-7. Cancer Res. 2000. PMID: 11016663
Endothelin (ET)-1 is produced in ovarian carcinoma cells and is known to act through ET(A) receptors as an autocrine growth factor in vitro and in vivo. ...In accord with this finding, the mitogenic action of ET-1 in OVCA 433 cells was also significantly reduced by a
Endothelin (ET)-1 is produced in ovarian carcinoma cells and is known to act through ET(A) receptors as an autocrine growth factor in …
Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy.
Venuti A, Salani D, Manni V, Poggiali F, Bagnato A. Venuti A, et al. Among authors: bagnato a. FASEB J. 2000 Nov;14(14):2277-83. doi: 10.1096/fj.00-0024com. FASEB J. 2000. PMID: 11053249
All HPV-positive cancer cells secreted ET-1 and expressed mRNA for ET-1 and its receptors, whereas a HPV-negative carcinoma cell line expressed only the ETBR mRNA and didn't secrete ET-1. ...ET-1 stimulated a marked dose-dependent increase in [3H]-thymidine incorpor …
All HPV-positive cancer cells secreted ET-1 and expressed mRNA for ET-1 and its receptors, whereas a HPV-negative carcinoma cell line …
Role of endothelin-1 in neovascularization of ovarian carcinoma.
Salani D, Di Castro V, Nicotra MR, Rosanò L, Tecce R, Venuti A, Natali PG, Bagnato A. Salani D, et al. Among authors: bagnato a. Am J Pathol. 2000 Nov;157(5):1537-47. doi: 10.1016/S0002-9440(10)64791-8. Am J Pathol. 2000. PMID: 11073813 Free PMC article.
Endothelin-1 (ET-1) is overexpressed in ovarian carcinomas and acts, via ET(A) receptors (ET(A)R), as an autocrine growth factor. ...The localization of functional ET(A)R and ET(A)R mRNA expression, as detected by autoradiography and in situ hybridizat …
Endothelin-1 (ET-1) is overexpressed in ovarian carcinomas and acts, via ET(A) receptors (ET(A)R), as an autocrine growth fact …
Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells.
Rosanò L, Varmi M, Salani D, Di Castro V, Spinella F, Natali PG, Bagnato A. Rosanò L, et al. Among authors: bagnato a. Cancer Res. 2001 Nov 15;61(22):8340-6. Cancer Res. 2001. PMID: 11719468
In these cells, ET-1 acts as an autocrine mitogenic and angiogenic factor selectively through the ET(A) receptor (ET(A)R). We investigated at mRNA and protein levels whether ET-1 could affect the expression and activation of metastasis-related proteinases and whethe …
In these cells, ET-1 acts as an autocrine mitogenic and angiogenic factor selectively through the ET(A) receptor (ET(A)R). We …
Endothelin-1 acts as a survival factor in ovarian carcinoma cells.
Del Bufalo D, Di Castro V, Biroccio A, Salani D, Rosanò L, Spinella F, Bagnato A. Del Bufalo D, et al. Among authors: bagnato a. Clin Sci (Lond). 2002 Aug;103 Suppl 48:302S-305S. doi: 10.1042/CS103S302S. Clin Sci (Lond). 2002. PMID: 12193109
ET-1 is a powerful mitogenic peptide produced by ovarian carcinomas and it acts as an autocrine growth factor, selectively through ET(A) receptor (ET(A)R), which is predominantly expressed in this tumour. ...Our results establish a novel role for ET-1 …
ET-1 is a powerful mitogenic peptide produced by ovarian carcinomas and it acts as an autocrine growth factor, selectively through ET …
Endothelin receptor blockade inhibits the growth of human papillomavirus-associated cervical carcinoma.
Venuti A, Salani D, Cirilli A, Simeone P, Muller A, Flamini S, Padley R, Bagnato A. Venuti A, et al. Among authors: bagnato a. Clin Sci (Lond). 2002 Aug;103 Suppl 48:310S-313S. doi: 10.1042/CS103S310S. Clin Sci (Lond). 2002. PMID: 12193111
In HPV-positive cancer cells, ET(A)R mediates the ET-1-induced mitogenic effect and sustains the basal growth rate of unstimulated cervical tumour cells. ...CaSki cells are HPV-16-positive, produce ET-1 and possess ET(A)R and ET(B)R, whereas the C33A line is HPV-neg …
In HPV-positive cancer cells, ET(A)R mediates the ET-1-induced mitogenic effect and sustains the basal growth rate of unstimulated ce …
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