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Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.
Joshi D, Bahekar R, Soman S, Jadav P, Patel D, Goswami A, Pethani J, Kumar J, Patel J, Sundar R, Goswami P, Goshdastidar K, Patel H, Patel A, Bandyopadhyay D, Chattarjee A, Sharma M, Jain M, Desai R. Joshi D, et al. Among authors: bahekar r. Bioorg Chem. 2023 Jan;130:106238. doi: 10.1016/j.bioorg.2022.106238. Epub 2022 Nov 14. Bioorg Chem. 2023. PMID: 36403335
ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.
Ghoshdastidar K, Patel H, Bhayani H, Patel A, Thakkar K, Patel D, Sharma M, Singh J, Mohapatra J, Chatterjee A, Patel D, Bahekar R, Sharma R, Gupta L, Patel N, Giri P, Srinivas NR, Jain M, Bandyopadhyay D, Patel PR, Desai RC. Ghoshdastidar K, et al. Among authors: bahekar r. Pharmacol Res Perspect. 2020 Aug;8(4):e00565. doi: 10.1002/prp2.565. Pharmacol Res Perspect. 2020. PMID: 32790160 Free PMC article.
Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors.
Bahekar R, Panchal N, Soman S, Desai J, Patel D, Argade A, Gite A, Gite S, Patel B, Kumar J, S S, Patel H, Sundar R, Chatterjee A, Mahapatra J, Patel H, Ghoshdastidar K, Bandyopadhyay D, Desai RC. Bahekar R, et al. Bioorg Chem. 2020 Jun;99:103851. doi: 10.1016/j.bioorg.2020.103851. Epub 2020 Apr 18. Bioorg Chem. 2020. PMID: 32334196
Suicidal risk and demoralization in Parkinson disease.
Elfil M, Ahmed N, Alapati A, Bahekar R, Kandil M, Kim C, Schaefer S, Tinaz S, Patel AS, de Figueiredo JM, Louis ED, Koo BB. Elfil M, et al. Among authors: bahekar r. J Neurol. 2020 Apr;267(4):966-974. doi: 10.1007/s00415-019-09632-2. Epub 2019 Dec 4. J Neurol. 2020. PMID: 31802218
47 results