Bai RL - Search Results

1

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

Bai RL, Lin CM, Nguyen NY, Liu TY, Hamel E. Bai RL, et al. Biochemistry. 1989 Jun 27;28(13):5606-12. doi: 10.1021/bi00439a040. Biochemistry. 1989. PMID: 2775724

2

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64. doi: 10.1016/0006-2952(90)90367-t. Biochem Pharmacol. 1990. PMID: 2242019

3

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739

4

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. J Biol Chem. 1990 Oct 5;265(28):17141-9. J Biol Chem. 1990. PMID: 2211617

5

Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.

Bai R, Durso NA, Sackett DL, Hamel E. Bai R, et al. Biochemistry. 1999 Oct 26;38(43):14302-10. doi: 10.1021/bi991323e. Biochemistry. 1999. PMID: 10572005

6

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

Bai R, Schwartz RE, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Cancer Res. 1996 Oct 1;56(19):4398-406. Cancer Res. 1996. PMID: 8813133

7

Identification of cysteine 354 of beta-tubulin as part of the binding site for the A ring of colchicine.

Bai R, Pei XF, Boyé O, Getahun Z, Grover S, Bekisz J, Nguyen NY, Brossi A, Hamel E. Bai R, et al. J Biol Chem. 1996 May 24;271(21):12639-45. doi: 10.1074/jbc.271.21.12639. J Biol Chem. 1996. PMID: 8647876

8

Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E. Bai R, et al. Biochem Pharmacol. 1993 Apr 6;45(7):1503-15. doi: 10.1016/0006-2952(93)90051-w. Biochem Pharmacol. 1993. PMID: 8471072

9

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E. Bai R, et al. Mol Pharmacol. 1993 Oct;44(4):757-66. Mol Pharmacol. 1993. PMID: 8232226

10

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.

Bai R, Taylor GF, Schmidt JM, Williams MD, Kepler JA, Pettit GR, Hamel E. Bai R, et al. Mol Pharmacol. 1995 May;47(5):965-76. Mol Pharmacol. 1995. PMID: 7746283

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