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Big conductance calcium-activated potassium channel openers control spasticity without sedation.
Baker D, Pryce G, Visintin C, Sisay S, Bondarenko AI, Vanessa Ho WS, Jackson SJ, Williams TE, Al-Izki S, Sevastou I, Okuyama M, Graier WF, Stevenson LA, Tanner C, Ross R, Pertwee RG, Henstridge CM, Irving AJ, Schulman J, Powell K, Baker MD, Giovannoni G, Selwood DL. Baker D, et al. Among authors: baker md. Br J Pharmacol. 2017 Aug;174(16):2662-2681. doi: 10.1111/bph.13889. Epub 2017 Jul 7. Br J Pharmacol. 2017. PMID: 28677901 Free PMC article. Clinical Trial.
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN. Maresz K, et al. Among authors: baker d. Nat Med. 2007 Apr;13(4):492-7. doi: 10.1038/nm1561. Epub 2007 Apr 1. Nat Med. 2007. PMID: 17401376
Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors.
Brooks JW, Pryce G, Bisogno T, Jaggar SI, Hankey DJ, Brown P, Bridges D, Ledent C, Bifulco M, Rice AS, Di Marzo V, Baker D. Brooks JW, et al. Among authors: baker d. Eur J Pharmacol. 2002 Mar 29;439(1-3):83-92. doi: 10.1016/s0014-2999(02)01369-9. Eur J Pharmacol. 2002. PMID: 11937096
5,620 results