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Application of Proteomics in Sarcoidosis.
Guerrero CR, Maier LA, Griffin TJ, Higgins L, Najt CP, Perlman DM, Bhargava M. Guerrero CR, et al. Am J Respir Cell Mol Biol. 2020 Dec;63(6):727-738. doi: 10.1165/rcmb.2020-0070PS. Am J Respir Cell Mol Biol. 2020. PMID: 32804537 Review.
Studies leveraging MS-based proteomics in sarcoidosis have characterized BAL fluid (BALF), alveolar macrophages, plasma, and exosomes. These studies identified several differentially expressed proteins, including protocadherin-2 precursor, annexin A2, pulmonary surfactant …
Studies leveraging MS-based proteomics in sarcoidosis have characterized BAL fluid (BALF), alveolar macrophages, plasma, and exosomes …
Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion.
Alexander CM, Xiong KN, Velmurugan K, Xiong J, Osgood RS, Bauer AK. Alexander CM, et al. Exp Lung Res. 2016 Apr;42(3):154-73. doi: 10.3109/01902148.2016.1164263. Exp Lung Res. 2016. PMID: 27093379 Free PMC article.
Our study objective was to elucidate the underlying differences in Tlr4 mutant mice in innate immune cell populations, their functional responses, and the influence of these cellular differences on ADC progenitor (type II) cells following BHT-treatment. BALB (Tlr4-sufficient) and …
Our study objective was to elucidate the underlying differences in Tlr4 mutant mice in innate immune cell populations, their functional resp …
Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children.
Sinha A, Gulati A, Saini S, Blanc C, Gupta A, Gurjar BS, Saini H, Kotresh ST, Ali U, Bhatia D, Ohri A, Kumar M, Agarwal I, Gulati S, Anand K, Vijayakumar M, Sinha R, Sethi S, Salmona M, George A, Bal V, Singh G, Dinda AK, Hari P, Rath S, Dragon-Durey MA, Bagga A; Indian HUS Registry. Sinha A, et al. Kidney Int. 2014 May;85(5):1151-60. doi: 10.1038/ki.2013.373. Epub 2013 Oct 2. Kidney Int. 2014. PMID: 24088957 Free article.
Antibody titers were high (mean 7054 AU/ml) and correlated inversely with levels of complement C3, but not complement factor H. Homozygous deletion of the CFHR1 gene was found in 60 of 68 patients. ...Significant independent risk factors for adverse outcome were an antibod …
Antibody titers were high (mean 7054 AU/ml) and correlated inversely with levels of complement C3, but not complement factor H. Homoz …
Identification of proteomic signatures associated with lung cancer and COPD.
Pastor MD, Nogal A, Molina-Pinelo S, Meléndez R, Salinas A, González De la Peña M, Martín-Juan J, Corral J, García-Carbonero R, Carnero A, Paz-Ares L. Pastor MD, et al. J Proteomics. 2013 Aug 26;89:227-37. doi: 10.1016/j.jprot.2013.04.037. Epub 2013 May 9. J Proteomics. 2013. PMID: 23665002 Clinical Trial.
The aim of this study was to identify distinct proteomic profiles able to discriminate these two pathological entities. Protein content was assessed in the bronchoalveolar lavage (BAL) of 60 patients classified in four groups: COPD, COPD and LC, LC without COPD, and contro …
The aim of this study was to identify distinct proteomic profiles able to discriminate these two pathological entities. Protein content was …
Generation of C5a in the absence of C3: a new complement activation pathway.
Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, McGuire SR, Lambris JD, Warner RL, Flierl MA, Hoesel LM, Gebhard F, Younger JG, Drouin SM, Wetsel RA, Ward PA. Huber-Lang M, et al. Nat Med. 2006 Jun;12(6):682-7. doi: 10.1038/nm1419. Epub 2006 May 21. Nat Med. 2006. PMID: 16715088
Injury in lungs of C3-/- mice and C5a levels in bronchoalveolar lavage (BAL) fluids from these mice were greatly reduced in the presence of antithrombin III (ATIII) or hirudin but were not reduced in similarly treated C3+/+ mice. ...There were higher levels o …
Injury in lungs of C3-/- mice and C5a levels in bronchoalveolar lavage (BAL) fluids from these mice were greatly reduced in th …
[Effect of rhubarb on intestinal immune associated secretion in healthy mice and in burn mice].
Chen XL, Huang XL, Wu H. Chen XL, et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct;21(10):754-6. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001. PMID: 12575609 Chinese.
The animals were killed 24 hrs after burn, the intestinal juice was collected after intestinal lavage, and centrifuged for determination of IgA, total protein, C3 and high density lipoprotein. RESULTS: IgA content in intestinal juice of Group A, B, C and D were 93.5 …
The animals were killed 24 hrs after burn, the intestinal juice was collected after intestinal lavage, and centrifuged for determination of …