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Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent.
Tonello G, Daglio M, Zaccarelli N, Sottofattori E, Mazzei M, Balbi A. Tonello G, et al. Among authors: balbi a. J Pharm Biomed Anal. 1996 Aug;14(11):1555-60. doi: 10.1016/0731-7085(96)01788-8. J Pharm Biomed Anal. 1996. PMID: 8877863
The polydeoxyribonucleotide (PDRN) fraction is an extract which forms the active component in a new formulation of the drug Placentex (a tissue repair stimulating agent), obtained from human placenta through an original proprietory extraction method. From a c …
The polydeoxyribonucleotide (PDRN) fraction is an extract which forms the active component in a new formulation of the drug Placentex …
Study of bioequivalence of magnesium and sodium valproates.
Balbi A, Sottofattori E, Mazzei M, Sannita WG. Balbi A, et al. J Pharm Biomed Anal. 1991;9(4):317-21. doi: 10.1016/0731-7085(91)80200-s. J Pharm Biomed Anal. 1991. PMID: 1911984
The two preparations were found to be bioequivalent; magnesium valproate appeared to be a drug without bioavailability problems and with reduced inter-subject variability, compared with that of sodium valproate. A reversed-phase HPLC method for the determination of …
The two preparations were found to be bioequivalent; magnesium valproate appeared to be a drug without bioavailability problems and w …
Simultaneous HPLC determination of multiple components in a commercial cosmetic cream.
Sottofattori E, Anzaldi M, Balbi A, Tonello G. Sottofattori E, et al. Among authors: balbi a. J Pharm Biomed Anal. 1998 Oct;18(1-2):213-7. doi: 10.1016/s0731-7085(98)00173-3. J Pharm Biomed Anal. 1998. PMID: 9863960
A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III), ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and ascorbyl palmita
A high-performance liquid chromatographic method for the simultaneous determination of magnesium ascorbyl phosphate (I), imidazolidin
Alkaline extraction and reverse-phase high-performance liquid chromatography of adenine and pyridine nucleotides in human platelets.
Leoncini G, Buzzi E, Maresca M, Mazzei M, Balbi A. Leoncini G, et al. Among authors: balbi a. Anal Biochem. 1987 Sep;165(2):379-83. doi: 10.1016/0003-2697(87)90285-5. Anal Biochem. 1987. PMID: 3425907
The levels of adenine (ATP, ADP, AMP) and pyridine (NAD, NADH) nucleotides in human platelets have been measured by a simple and reproducible method. A rapid alkaline extraction allows a complete recovery of the compounds concerned. The metabolic ATP and ADP …
The levels of adenine (ATP, ADP, AMP) and pyridine (NAD, NADH) nucleotides in human platelets have been measured by a simple and repr …
Synthesis and hybridization properties of the conjugates of oligonucleotides and stabilization agents. Part 3.
Sottofattori E, Anzaldi M, Mazzei M, Miele M, Balbi A, Pyshnyi DS, Zakharova OD, Abramova TV. Sottofattori E, et al. Among authors: balbi a. Bioorg Med Chem. 2005 Mar 1;13(5):1515-22. doi: 10.1016/j.bmc.2004.12.030. Bioorg Med Chem. 2005. PMID: 15698767
The effect of all these compounds on the stability of the oligonucleotide complexes (DeltaDeltaG at 37 degrees C ranged from -1.2 to -2.0 kcal/mol) was shown to be comparable to the effect of one nucleotide base pair and similar to the effect (DeltaDeltaG at 37 degrees C ranged f …
The effect of all these compounds on the stability of the oligonucleotide complexes (DeltaDeltaG at 37 degrees C ranged from -1.2 to -2.0 kc …
Synthesis in solution of oligodeoxynucleotides and some their 5'- and 3'-linked derivatives.
Mazzei M, Balbi A, Grandi T, Sottofattori E, Garzoglio R, Abramova T, Ivanova E. Mazzei M, et al. Among authors: balbi a. Farmaco. 1993 Dec;48(12):1649-61. Farmaco. 1993. PMID: 8135989
In view of performing more extensive pharmacological trials requiring relatively great amounts of ODNs, we used a method of ODN synthesis derived from the phosphotriester approach which allow to prepare ODNs covalently linking cholesteryl residue (in 5' or 3') and phenazin …
In view of performing more extensive pharmacological trials requiring relatively great amounts of ODNs, we used a method of ODN synth …
Formation of 2,6-dimethoxy-1,4-benzoquinone, a highly genotoxic compound, from the reaction of sodium nitrite with the sympathomimetic drug dimethophrine in acidic aqueous solution.
Mazzei M, Roma G, Balbi A, Sottofattori E, Robbiano L. Mazzei M, et al. Among authors: balbi a. Farmaco Sci. 1988 Jun;43(6):523-38. Farmaco Sci. 1988. PMID: 3208895
Actually, depending on the operating conditions, it was possible to detect variable amounts of 2,6-dimethoxy-1,4-benzoquinone (DMBQ), a highly genotoxic compound, but no N-nitrosoderivative. ...When DMP hydrochloride and NaNO2 (molar ratio 1:0.95) were allowed to react at …
Actually, depending on the operating conditions, it was possible to detect variable amounts of 2,6-dimethoxy-1,4-benzoquinone (DMBQ), a
HPLC analysis of the nitrosation products of chlordiazepoxide.
Mazzei M, Balbi A, Roma G, Di Braccio M, Robbiano L. Mazzei M, et al. Among authors: balbi a. Farmaco. 1989 Sep;44(9):883-91. Farmaco. 1989. PMID: 2604839
Since in the meantime the genotoxicity of (II) was proved, "in vivo" formation of N-nitrosochlordiazepoxide (II) represents a potential risk not to be underestimated....
Since in the meantime the genotoxicity of (II) was proved, "in vivo" formation of N-nitrosochlordiazepoxide (II) represents a potenti …
HPLC determination of azidothymidine (AZT) and its metabolite in human plasma.
Mazzei M, Balbi A, Sottofattori E, Bruzzo C, Palamone G, Nicolin A. Mazzei M, et al. Among authors: balbi a. Farmaco. 1990 Jun;45(6 Suppl):737-43. Farmaco. 1990. PMID: 2400523
In order to evaluate the amount of Azidothymidine (AZT) and its metabolite (GAZT) in human plasma, the HPLC retention times of both compounds on a C18 column as well as on an anionic column by using, as eluent, the same mobile phase have been studied. The two chromatograph …
In order to evaluate the amount of Azidothymidine (AZT) and its metabolite (GAZT) in human plasma, the HPLC retention times of both compound …
[Synthesis and preliminary pharmacological screening of 2,4-disubstituted N,N-dialkyl-1,8-naphthyridine-3-carboxamides].
Di Braccio M, Roma G, Balbi A, Sottofattori E, Carazzone M. Di Braccio M, et al. Among authors: balbi a. Farmaco. 1989 Sep;44(9):865-81. Farmaco. 1989. PMID: 2604838 Italian.
The reaction of compounds (II) with an excess of refluxing phosphorus oxychloride afforded N,N-dialkyl-2,4-dichloro-1,8-naphthyridine-3-carboxamides (III), which in turn were treated at room temperature with excess primary amines to give a mixture of isomeric N,N-dialkyl-2 …
The reaction of compounds (II) with an excess of refluxing phosphorus oxychloride afforded N,N-dialkyl-2,4-dichloro-1,8-naphthyridine-3-carb …
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