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GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss.
Addington AM, Gornick M, Duckworth J, Sporn A, Gogtay N, Bobb A, Greenstein D, Lenane M, Gochman P, Baker N, Balkissoon R, Vakkalanka RK, Weinberger DR, Rapoport JL, Straub RE. Addington AM, et al. Among authors: balkissoon r. Mol Psychiatry. 2005 Jun;10(6):581-8. doi: 10.1038/sj.mp.4001599. Mol Psychiatry. 2005. PMID: 15505639 Clinical Trial.
Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS).
Gornick MC, Addington AM, Sporn A, Gogtay N, Greenstein D, Lenane M, Gochman P, Ordonez A, Balkissoon R, Vakkalanka R, Weinberger DR, Rapoport JL, Straub RE. Gornick MC, et al. Among authors: balkissoon r. J Autism Dev Disord. 2005 Dec;35(6):831-8. doi: 10.1007/s10803-005-0028-3. J Autism Dev Disord. 2005. PMID: 16283082
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.
Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Egan MF, et al. Among authors: balkissoon r. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9. doi: 10.1073/pnas.0405077101. Epub 2004 Aug 13. Proc Natl Acad Sci U S A. 2004. PMID: 15310849 Free PMC article.
Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
Callicott JH, Straub RE, Pezawas L, Egan MF, Mattay VS, Hariri AR, Verchinski BA, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg TE, Weinberger DR. Callicott JH, et al. Among authors: balkissoon r. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8627-32. doi: 10.1073/pnas.0500515102. Epub 2005 Jun 6. Proc Natl Acad Sci U S A. 2005. PMID: 15939883 Free PMC article.
Serine racemase binds to PICK1: potential relevance to schizophrenia.
Fujii K, Maeda K, Hikida T, Mustafa AK, Balkissoon R, Xia J, Yamada T, Ozeki Y, Kawahara R, Okawa M, Huganir RL, Ujike H, Snyder SH, Sawa A. Fujii K, et al. Among authors: balkissoon r. Mol Psychiatry. 2006 Feb;11(2):150-7. doi: 10.1038/sj.mp.4001776. Mol Psychiatry. 2006. PMID: 16314870 Clinical Trial.
Evidence of association between bipolar disorder and Citron on chromosome 12q24.
Lyons-Warren A, Chang JJ, Balkissoon R, Kamiya A, Garant M, Nurnberger J, Scheftner W, Reich T, McMahon F, Kelsoe J, Gershon E, Coryell W, Byerley W, Berrettini W, Depaulo R, McInnis M, Sawa A. Lyons-Warren A, et al. Among authors: balkissoon r. Mol Psychiatry. 2005 Sep;10(9):807-9. doi: 10.1038/sj.mp.4001703. Mol Psychiatry. 2005. PMID: 15983625 No abstract available.
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