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A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours.
Wilky BA, Rudek MA, Ahmed S, Laheru DA, Cosgrove D, Donehower RC, Nelkin B, Ball D, Doyle LA, Chen H, Ye X, Bigley G, Womack C, Azad NS. Wilky BA, et al. Br J Cancer. 2015 Jan 6;112(1):24-31. doi: 10.1038/bjc.2014.515. Epub 2014 Sep 30. Br J Cancer. 2015. PMID: 25268371 Free PMC article. Clinical Trial.
Notch in malignancy.
Ball DW, Leach SD. Ball DW, et al. Cancer Treat Res. 2003;115:95-121. doi: 10.1007/0-306-48158-8_4. Cancer Treat Res. 2003. PMID: 12613194 Review. No abstract available.
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