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Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.
Massa L, Baltrusch S, Okar DA, Lange AJ, Lenzen S, Tiedge M. Massa L, et al. Diabetes. 2004 Apr;53(4):1020-9. doi: 10.2337/diabetes.53.4.1020. Diabetes. 2004. PMID: 15047617
Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.
Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L. Arden C, et al. Diabetes. 2004 Sep;53(9):2346-52. doi: 10.2337/diabetes.53.9.2346. Diabetes. 2004. PMID: 15331544
Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.
Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S. Baltrusch S, et al. Endocrinology. 2006 Dec;147(12):5768-76. doi: 10.1210/en.2006-0694. Epub 2006 Sep 15. Endocrinology. 2006. PMID: 16980436
Regulation of [Ca2+]i oscillations in mouse pancreatic islets by adrenergic agonists.
Baltrusch S, Lenzen S. Baltrusch S, et al. Biochem Biophys Res Commun. 2007 Nov 30;363(4):1038-43. doi: 10.1016/j.bbrc.2007.09.028. Epub 2007 Sep 18. Biochem Biophys Res Commun. 2007. PMID: 17923116
Kinetics of insulin secretion from MIN6 pseudoislets after encapsulation in a prototype device of a bioartificial pancreas.
Barrientos R, Baltrusch S, Sigrist S, Legeay G, Belcourt A, Lenzen S. Barrientos R, et al. Horm Metab Res. 2009 Jan;41(1):5-9. doi: 10.1055/s-0028-1087185. Epub 2008 Oct 14. Horm Metab Res. 2009. PMID: 18855306
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