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The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.
Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen AG, Holderfield M, Satchell KJF. Biancucci M, et al. Among authors: banerjee a. Sci Signal. 2018 Oct 2;11(550):eaat8335. doi: 10.1126/scisignal.aat8335. Sci Signal. 2018. PMID: 30279169 Free PMC article.
The higher level of complexity of K-Ras4B activation at the membrane.
Jang H, Banerjee A, Chavan TS, Lu S, Zhang J, Gaponenko V, Nussinov R. Jang H, et al. Among authors: banerjee a. FASEB J. 2016 Apr;30(4):1643-55. doi: 10.1096/fj.15-279091. Epub 2015 Dec 30. FASEB J. 2016. PMID: 26718888 Free PMC article.
Importantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activation.-Jang, H., Banerjee, A., Chavan, T. S, Lu, S., Zhang, J., Gaponenko, V., Nussinov, R. ...
Importantly, K-Ras4B-GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activation.-Jang, H., Ba
Calmodulin and PI3K Signaling in KRAS Cancers.
Nussinov R, Wang G, Tsai CJ, Jang H, Lu S, Banerjee A, Zhang J, Gaponenko V. Nussinov R, et al. Among authors: banerjee a. Trends Cancer. 2017 Mar;3(3):214-224. doi: 10.1016/j.trecan.2017.01.007. Epub 2017 Feb 18. Trends Cancer. 2017. PMID: 28462395 Free PMC article. Review.
5,731 results