Lipoprotein Lipase Sorting: Sphingomyelin and a Proteoglycan Show the Way

Vytas A Bankaitis; Yaxi Wang

doi:10.1016/j.tcb.2020.01.001

Lipoprotein Lipase Sorting: Sphingomyelin and a Proteoglycan Show the Way

Trends Cell Biol. 2020 Mar;30(3):170-172. doi: 10.1016/j.tcb.2020.01.001. Epub 2020 Jan 22.

Authors

Vytas A Bankaitis¹, Yaxi Wang²

Affiliations

¹ Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843-1114, USA; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. Electronic address: vytas@tamu.edu.
² Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA.

PMID: 31982238
DOI: 10.1016/j.tcb.2020.01.001

Abstract

A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al. reveal that sphingomyelin and a proteoglycan mediate lipoprotein lipase sorting in the TGN.

MeSH terms

Animals
Humans
Lipoprotein Lipase / metabolism*
Models, Biological
Protein Transport
Proteoglycans / metabolism*
Sphingomyelins / metabolism*
Syndecan-1 / metabolism

Substances

Proteoglycans
Sphingomyelins
Syndecan-1
Lipoprotein Lipase