Barakat K - Search Results

1

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.

Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K. Ganesan A, et al. Among authors: barakat k. Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6. Sci Rep. 2019. PMID: 31455818 Free PMC article.

2

Discovery of small molecule inhibitors that interact with γ-tubulin.

Friesen DE, Barakat KH, Semenchenko V, Perez-Pineiro R, Fenske BW, Mane J, Wishart DS, Tuszynski JA. Friesen DE, et al. Chem Biol Drug Des. 2012 May;79(5):639-52. doi: 10.1111/j.1747-0285.2012.01340.x. Epub 2012 Feb 15. Chem Biol Drug Des. 2012. PMID: 22268380

3

A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant.

Barakat KH, Huzil JT, Jordan KE, Evangelinos C, Houghton M, Tuszynski J. Barakat KH, et al. Mol Pharm. 2013 Dec 2;10(12):4572-89. doi: 10.1021/mp4003893. Epub 2013 Nov 5. Mol Pharm. 2013. PMID: 24094068

4

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Barakat KH, Law J, Prunotto A, Magee WC, Evans DH, Tyrrell DL, Tuszynski J, Houghton M. Barakat KH, et al. J Chem Inf Model. 2013 Nov 25;53(11):3031-43. doi: 10.1021/ci4003969. Epub 2013 Oct 24. J Chem Inf Model. 2013. PMID: 24116674

5

Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus.

Egli A, Levin A, Santer DM, Joyce M, O'Shea D, Thomas BS, Lisboa LF, Barakat K, Bhat R, Fischer KP, Houghton M, Tyrrell DL, Kumar D, Humar A. Egli A, et al. Among authors: barakat k. J Infect Dis. 2014 Sep 1;210(5):717-27. doi: 10.1093/infdis/jiu144. Epub 2014 Mar 11. J Infect Dis. 2014. PMID: 24620020

6

A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

Barakat KH, Anwar-Mohamed A, Tuszynski JA, Robins MJ, Tyrrell DL, Houghton M. Barakat KH, et al. J Chem Inf Model. 2015 Feb 23;55(2):362-73. doi: 10.1021/ci400631n. Epub 2014 Apr 14. J Chem Inf Model. 2015. PMID: 24730573

7

Vaccine adjuvants--understanding molecular mechanisms to improve vaccines.

Egli A, Santer D, Barakat K, Zand M, Levin A, Vollmer M, Weisser M, Khanna N, Kumar D, Tyrrell L, Houghton M, Battegay M, O'Shea D. Egli A, et al. Among authors: barakat k. Swiss Med Wkly. 2014 May 20;144:w13940. doi: 10.4414/smw.2014.13940. eCollection 2014. Swiss Med Wkly. 2014. PMID: 24844935 Free article. Review.

8

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M. Anwar-Mohamed A, et al. Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007. Epub 2014 Aug 13. Toxicol Lett. 2014. PMID: 25127758

9

Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.

Ahmed M, Wang F, Levin A, Le C, Eltayebi Y, Houghton M, Tyrrell L, Barakat K. Ahmed M, et al. Among authors: barakat k. Drug Discov Today. 2015 May;20(5):548-61. doi: 10.1016/j.drudis.2015.01.008. Epub 2015 Jan 24. Drug Discov Today. 2015. PMID: 25622780 Review.

10

Human PD-1 binds differently to its human ligands: a comprehensive modeling study.

Viricel C, Ahmed M, Barakat K. Viricel C, et al. Among authors: barakat k. J Mol Graph Model. 2015 Apr;57:131-42. doi: 10.1016/j.jmgm.2015.01.015. Epub 2015 Feb 14. J Mol Graph Model. 2015. PMID: 25723350

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