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Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2.
Barbu A, Welsh N, Saldeen J. Barbu A, et al. Mol Cell Endocrinol. 2002 Apr 25;190(1-2):75-82. doi: 10.1016/s0303-7207(02)00009-6. Mol Cell Endocrinol. 2002. PMID: 11997180
A nitric oxide synthase-, but not a ROS-inhibitor, prevented cytokine-induced loss of Deltapsi(m). Overexpression of the anti-apoptotic protein Bcl-2 increased both JC-1 and DCFH-DA fluorescence, which was paralleled by protection against cytokine-induced apoptosis
A nitric oxide synthase-, but not a ROS-inhibitor, prevented cytokine-induced loss of Deltapsi(m). Overexpression of the anti-
Accelerated proliferation and differential global gene expression in pancreatic islets of five-week-old heterozygous Men1 mice: Men1 is a haploinsufficient suppressor.
Lejonklou MH, Barbu A, Stålberg P, Skogseid B. Lejonklou MH, et al. Among authors: barbu a. Endocrinology. 2012 Jun;153(6):2588-98. doi: 10.1210/en.2011-1924. Epub 2012 Apr 4. Endocrinology. 2012. PMID: 22492302
Individuals carrying heterozygous (hz) MEN1 (Multiple Endocrine Neoplasia Syndrome Type 1) germ line mutations develop endocrine tumors as a result of somatic loss of the wild-type (wt) allele. ...To study downstream molecular effects of the hz haplotype, a germ lin …
Individuals carrying heterozygous (hz) MEN1 (Multiple Endocrine Neoplasia Syndrome Type 1) germ line mutations develop endocrine tumors as …
Overexpression of the nuclear factor-κB subunit c-Rel protects against human islet cell death in vitro.
Mokhtari D, Barbu A, Mehmeti I, Vercamer C, Welsh N. Mokhtari D, et al. Among authors: barbu a. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1067-77. doi: 10.1152/ajpendo.00212.2009. Epub 2009 Aug 25. Am J Physiol Endocrinol Metab. 2009. PMID: 19706790
The transcription factor nuclear factor (NF)-κB is known to modulate rates of apoptosis and may therefore play a role in the increased β-cell death that occurs in type 1 and type 2 diabetes. ...We conclude that rpS3 participates in NF-κB signaling and that a genetic …
The transcription factor nuclear factor (NF)-κB is known to modulate rates of apoptosis and may therefore play a role in the increase …
Pref-1 and adipokine expression in adipose tissues of GK and Zucker rats.
Barbu A, Hedlund GP, Lind J, Carlsson C. Barbu A, et al. Mol Cell Endocrinol. 2009 Feb 27;299(2):163-71. doi: 10.1016/j.mce.2008.11.019. Epub 2008 Nov 25. Mol Cell Endocrinol. 2009. PMID: 19084046
Lipofection of insulin-producing RINm5F cells: methodological improvements.
Barbu A, Welsh N. Barbu A, et al. J Liposome Res. 2007;17(2):49-62. doi: 10.1080/01676830701374986. J Liposome Res. 2007. PMID: 17613696
In addition, we have determined the influences of centrifugation, serum and a nuclear localization signal peptide on the lipofection efficiency. ...Finally, both centrifugation and a nuclear localization signal peptide increased transfection efficiency....
In addition, we have determined the influences of centrifugation, serum and a nuclear localization signal peptide on the lipofection …
Pancreatic islet blood flow and its measurement.
Jansson L, Barbu A, Bodin B, Drott CJ, Espes D, Gao X, Grapensparr L, Källskog Ö, Lau J, Liljebäck H, Palm F, Quach M, Sandberg M, Strömberg V, Ullsten S, Carlsson PO. Jansson L, et al. Among authors: barbu a. Ups J Med Sci. 2016 May;121(2):81-95. doi: 10.3109/03009734.2016.1164769. Epub 2016 Apr 28. Ups J Med Sci. 2016. PMID: 27124642 Free PMC article. Review.
Multiple microvascular alterations in pancreatic islets and neuroendocrine tumors of a Men1 mouse model.
Chu X, Gao X, Jansson L, Quach M, Skogseid B, Barbu A. Chu X, et al. Among authors: barbu a. Am J Pathol. 2013 Jun;182(6):2355-67. doi: 10.1016/j.ajpath.2013.02.023. Epub 2013 Apr 12. Am J Pathol. 2013. PMID: 23583653
We highlight structural, molecular, and functional microvascular aberrations contributing to development and maintenance of pancreatic neuroendocrine tumors (NETs), with special reference to multiple endocrine neoplasia 1 (MEN1) syndrome, using a Men1 mouse model. ...
We highlight structural, molecular, and functional microvascular aberrations contributing to development and maintenance of pancreatic neuro …
Activated pancreatic stellate cells can impair pancreatic islet function in mice.
Zang G, Sandberg M, Carlsson PO, Welsh N, Jansson L, Barbu A. Zang G, et al. Among authors: barbu a. Ups J Med Sci. 2015;120(3):169-80. doi: 10.3109/03009734.2015.1032453. Epub 2015 Apr 8. Ups J Med Sci. 2015. PMID: 25854824 Free PMC article.
Increased islet cell caspase-3 activation and a decreased islet cell replication were consistently observed after co-culture for 2 or 7 days. ...
Increased islet cell caspase-3 activation and a decreased islet cell replication were consistently observed after co-culture for 2 or …
Novel experimental strategies to prevent the development of type 1 diabetes mellitus.
Sandler S, Andersson AK, Barbu A, Hellerström C, Holstad M, Karlsson E, Sandberg JO, Strandell E, Saldeen J, Sternesjö J, Tillmar L, Eizirik DL, Flodström M, Welsh N. Sandler S, et al. Among authors: barbu a. Ups J Med Sci. 2000;105(2):17-34. doi: 10.1517/03009734000000053. Ups J Med Sci. 2000. PMID: 11095103 Review.
However, other induced proteins SUCH AS heat shock protein 70 and superoxide dismutase may reflect a defense reaction elicited in the beta-cells by the cytokines. ...
However, other induced proteins SUCH AS heat shock protein 70 and superoxide dismutase may reflect a defense reaction elicited in the …
A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans.
Barbu AR, Bodin B, Welsh M, Jansson L, Welsh N. Barbu AR, et al. Diabetologia. 2006 Oct;49(10):2388-91. doi: 10.1007/s00125-006-0390-5. Epub 2006 Aug 30. Diabetologia. 2006. PMID: 16944093
AIMS/HYPOTHESIS: Successful gene transfer to pancreatic islets might be a powerful tool for dissecting the biological pathways involved in the functional impairment and destruction of beta cells in type 1 diabetes. ...We present here a whole-pancreas perfusion-based …
AIMS/HYPOTHESIS: Successful gene transfer to pancreatic islets might be a powerful tool for dissecting the biological pathways involv …
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