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LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.
Ossipova O, Bardeesy N, DePinho RA, Green JB. Ossipova O, et al. Nat Cell Biol. 2003 Oct;5(10):889-94. doi: 10.1038/ncb1048. Epub 2003 Sep 14. Nat Cell Biol. 2003. PMID: 12973359
Altered exocrine function can drive adipose wasting in early pancreatic cancer.
Danai LV, Babic A, Rosenthal MH, Dennstedt EA, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardeesy N, Fernandez-Del Castillo C, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG. Danai LV, et al. Nature. 2018 Jun;558(7711):600-604. doi: 10.1038/s41586-018-0235-7. Epub 2018 Jun 20. Nature. 2018. PMID: 29925948 Free PMC article.
Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.
Swisa A, Granot Z, Tamarina N, Sayers S, Bardeesy N, Philipson L, Hodson DJ, Wikstrom JD, Rutter GA, Leibowitz G, Glaser B, Dor Y. Swisa A, et al. J Biol Chem. 2015 Aug 21;290(34):20934-46. doi: 10.1074/jbc.M115.639237. Epub 2015 Jul 2. J Biol Chem. 2015. PMID: 26139601 Free PMC article.
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH. Nakada Y, et al. PLoS One. 2013 Sep 25;8(9):e73449. doi: 10.1371/journal.pone.0073449. eCollection 2013. PLoS One. 2013. PMID: 24086281 Free PMC article.
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. Shaw RJ, et al. Science. 2005 Dec 9;310(5754):1642-6. doi: 10.1126/science.1120781. Epub 2005 Nov 24. Science. 2005. PMID: 16308421 Free PMC article.
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. Shaw RJ, et al. Cancer Cell. 2004 Jul;6(1):91-9. doi: 10.1016/j.ccr.2004.06.007. Cancer Cell. 2004. PMID: 15261145
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP. Katajisto P, et al. Nat Genet. 2008 Apr;40(4):455-9. doi: 10.1038/ng.98. Epub 2008 Mar 2. Nat Genet. 2008. PMID: 18311138
LKB1 regulates pancreatic beta cell size, polarity, and function.
Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ Jr, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y. Granot Z, et al. Cell Metab. 2009 Oct;10(4):296-308. doi: 10.1016/j.cmet.2009.08.010. Cell Metab. 2009. PMID: 19808022 Free PMC article.
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK. Carretero J, et al. Cancer Cell. 2010 Jun 15;17(6):547-59. doi: 10.1016/j.ccr.2010.04.026. Cancer Cell. 2010. PMID: 20541700 Free PMC article.
YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29.
Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. Tumaneng K, et al. Nat Cell Biol. 2012 Dec;14(12):1322-9. doi: 10.1038/ncb2615. Nat Cell Biol. 2012. PMID: 23143395 Free PMC article.
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