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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.
Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Samuel MS, et al. Among authors: barker n. Cancer Cell. 2011 Jun 14;19(6):776-91. doi: 10.1016/j.ccr.2011.05.008. Cancer Cell. 2011. PMID: 21665151 Free PMC article.
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.
Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E. Flanagan DJ, et al. Among authors: barker n. Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16. Stem Cell Reports. 2015. PMID: 25892522 Free PMC article.
The Yin-Yang of TCF/beta-catenin signaling.
Barker N, Morin PJ, Clevers H. Barker N, et al. Adv Cancer Res. 2000;77:1-24. doi: 10.1016/s0065-230x(08)60783-6. Adv Cancer Res. 2000. PMID: 10549354 Review.
Mining the Wnt pathway for cancer therapeutics.
Barker N, Clevers H. Barker N, et al. Nat Rev Drug Discov. 2006 Dec;5(12):997-1014. doi: 10.1038/nrd2154. Nat Rev Drug Discov. 2006. PMID: 17139285 Review.
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.
Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, Sapkota GP, Purdie KJ, Proby CM, Harwood CA, Leigh IM, Clevers H, Barker N, Karlsson S, Pritchard C, Marais R, Chelala C, South AP, Sansom OJ, Inman GJ. Cammareri P, et al. Among authors: barker n. Nat Commun. 2016 Aug 25;7:12493. doi: 10.1038/ncomms12493. Nat Commun. 2016. PMID: 27558455 Free PMC article.
448 results