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Did you mean carminomycin (461 results)?
Barminomycin, a model for the development of new anthracyclines.
Kimura K, Spencer DM, Bilardi R, Swift LP, Box AJ, Brownlee RT, Cutts SM, Phillips DR. Kimura K, et al. Anticancer Agents Med Chem. 2010 Jan;10(1):70-7. doi: 10.2174/1871520611009010070. Anticancer Agents Med Chem. 2010. PMID: 19807684 Review.
The imine form confers exceptional activity to barminomycin which is 1,000-fold more cytotoxic than doxorubicin. Barminomycin rapidly forms adducts with DNA, reacting with the exocyclic amino group of guanine residues and with high selectivity for 5'-GC-3' sequences …
The imine form confers exceptional activity to barminomycin which is 1,000-fold more cytotoxic than doxorubicin. Barminomycin …
Barminomycin functions as a potent pre-activated analogue of Adriamycin.
Moufarij MA, Cutts SM, Neumann GM, Kimura K, Phillips DR. Moufarij MA, et al. Chem Biol Interact. 2001 Nov 28;138(2):137-53. doi: 10.1016/s0009-2797(01)00267-8. Chem Biol Interact. 2001. PMID: 11672697
Surprisingly, barminomycin-DNA adducts are substantially more stable (essentially irreversible) than Adriamycin-DNA adducts (half life of approximately 25 h at 37 degrees C). Due to this understanding of the reactivity of barminomycin and its exceptional cytotoxicit …
Surprisingly, barminomycin-DNA adducts are substantially more stable (essentially irreversible) than Adriamycin-DNA adducts (half lif …
Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA.
Perrin LC, Cullinane C, Kimura K, Phillips DR. Perrin LC, et al. Nucleic Acids Res. 1999 Apr 15;27(8):1781-7. doi: 10.1093/nar/27.8.1781. Nucleic Acids Res. 1999. PMID: 10101184 Free PMC article.
The sequence specificity of the binding of barminomycin (SN-07 chromophore) to DNA was investigated using an in vitro transcription assay. ...Whereas adriamycin requires prior activation with formaldehyde in order to form adducts and crosslinks, barminomycin behaves …
The sequence specificity of the binding of barminomycin (SN-07 chromophore) to DNA was investigated using an in vitro transcription a …
New biosynthetic anthracyclines related to barminomycins incorporating barbiturates in their moiety.
Cassinelli G, Arlandini E, Ballabio M, Bordoni T, Geroni C, Giuliani F, Grein A, Merli S, Rivola G. Cassinelli G, et al. J Antibiot (Tokyo). 1990 Jan;43(1):19-28. doi: 10.7164/antibiotics.43.19. J Antibiot (Tokyo). 1990. PMID: 2307627 Free article.
Structural assignment, achieved through spectroscopic and degradative studies, that the new anthracyclines had a common barminomycin-like structure incorporating different barbiturate moieties. The new anthracyclines were found to display outstanding cytotoxicity and remar …
Structural assignment, achieved through spectroscopic and degradative studies, that the new anthracyclines had a common barminomycin- …
DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair.
Spencer DM, Bilardi RA, Koch TH, Post GC, Nafie JW, Kimura K, Cutts SM, Phillips DR. Spencer DM, et al. Mutat Res. 2008 Feb 1;638(1-2):110-21. doi: 10.1016/j.mrfmmm.2007.09.005. Epub 2007 Sep 16. Mutat Res. 2008. PMID: 17961607
The treatments used were doxorubicin, barminomycin (a model adduct-forming anthracycline) and doxoform (a doxorubicin-formaldehyde conjugate). ...Conversely, two HR deficient cell lines were shown to be more sensitive to barminomycin and doxoform than HR proficient …
The treatments used were doxorubicin, barminomycin (a model adduct-forming anthracycline) and doxoform (a doxorubicin-formaldehyde co …
Structural requirements for the formation of anthracycline-DNA adducts.
Cutts SM, Parker BS, Swift LP, Kimura KI, Phillips DR. Cutts SM, et al. Anticancer Drug Des. 2000 Oct;15(5):373-86. Anticancer Drug Des. 2000. PMID: 11354313
A series of anthracyclines (comprising carminomycins I, II and III, and barminomycin) were tested for their ability to react with DNA to form site-specific adducts using an in vitro transcription assay. The requirement for drug activation by formaldehyde was also assessed …
A series of anthracyclines (comprising carminomycins I, II and III, and barminomycin) were tested for their ability to react with DNA …
Detection of labile anthracycline-DNA adducts by real-time PCR.
Spencer DM, Cutts SM, Kimura K, Gray PJ, Phillips DR. Spencer DM, et al. Oncol Res. 2003;13(11):479-89. doi: 10.3727/000000003108748009. Oncol Res. 2003. PMID: 12812362
Barminomycin was employed as a model anthracycline that yields thermally stable drug-DNA adducts. Real-time PCR was utilized for the detection of these barminomycin-DNA adducts at drug levels as low as 100 nM in a cell-free assay system, with the lowest level of det …
Barminomycin was employed as a model anthracycline that yields thermally stable drug-DNA adducts. Real-time PCR was utilized for the …
New potent anthracyclines, barminomycins I and II.
Uchida T, Imoto M, Takahashi Y, Odagawa A, Sawa T, Tatsuta K, Naganawa H, Hamada M, Takeuchi T, Umezawa H. Uchida T, et al. J Antibiot (Tokyo). 1988 Mar;41(3):404-8. doi: 10.7164/antibiotics.41.404. J Antibiot (Tokyo). 1988. PMID: 3163334 Free article. No abstract available.
The structure of SN-07 chromophore.
Kimura K, Nakayama S, Miyata N, Takeshita Y, Kawanishi G. Kimura K, et al. J Antibiot (Tokyo). 1988 Mar;41(3):411-4. doi: 10.7164/antibiotics.41.411. J Antibiot (Tokyo). 1988. PMID: 3366698 Free article. No abstract available.
13 results