Barnett SF - Search Results

1

Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

Bilodeau MT, Balitza AE, Hoffman JM, Manley PJ, Barnett SF, Defeo-Jones D, Haskell K, Jones RE, Leander K, Robinson RG, Smith AM, Huber HE, Hartman GD. Bilodeau MT, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3178-82. doi: 10.1016/j.bmcl.2008.04.074. Epub 2008 May 1. Bioorg Med Chem Lett. 2008. PMID: 18479914

2

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

Lindsley CW, Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME. Lindsley CW, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. doi: 10.1016/j.bmcl.2004.11.011. Bioorg Med Chem Lett. 2005. PMID: 15664853

3

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.

Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME, Lindsley CW. Zhao Z, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2005 Feb 15;15(4):905-9. doi: 10.1016/j.bmcl.2004.12.062. Bioorg Med Chem Lett. 2005. PMID: 15686884

4

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members.

DeFeo-Jones D, Barnett SF, Fu S, Hancock PJ, Haskell KM, Leander KR, McAvoy E, Robinson RG, Duggan ME, Lindsley CW, Zhao Z, Huber HE, Jones RE. DeFeo-Jones D, et al. Among authors: barnett sf. Mol Cancer Ther. 2005 Feb;4(2):271-9. Mol Cancer Ther. 2005. PMID: 15713898

5

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation.

Barnett SF, Bilodeau MT, Lindsley CW. Barnett SF, et al. Curr Top Med Chem. 2005;5(2):109-25. doi: 10.2174/1568026053507714. Curr Top Med Chem. 2005. PMID: 15853641 Review.

6

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.

Zhao Z, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huber HE, Duggan ME, Lindsley CW. Zhao Z, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Jan 1;18(1):49-53. doi: 10.1016/j.bmcl.2007.11.015. Epub 2007 Nov 13. Bioorg Med Chem Lett. 2008. PMID: 18054229

7

Development of pyridopyrimidines as potent Akt1/2 inhibitors.

Wu Z, Hartnett JC, Neilson LA, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Hartman GD, Bilodeau MT. Wu Z, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1274-9. doi: 10.1016/j.bmcl.2008.01.054. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18249537

8

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.

Hartnett JC, Barnett SF, Bilodeau MT, Defeo-Jones D, Hartman GD, Huber HE, Jones RE, Kral AM, Robinson RG, Wu Z. Hartnett JC, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2194-7. doi: 10.1016/j.bmcl.2007.12.040. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18294842

9

Rapid assembly of diverse and potent allosteric Akt inhibitors.

Wu Z, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Kohl NE, Hartman GD, Bilodeau MT. Wu Z, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2211-4. doi: 10.1016/j.bmcl.2007.10.023. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18296048

10

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.

Siu T, Liang J, Arruda J, Li Y, Jones RE, Defeo-Jones D, Barnett SF, Robinson RG. Siu T, et al. Among authors: barnett sf. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4186-90. doi: 10.1016/j.bmcl.2008.05.085. Epub 2008 May 24. Bioorg Med Chem Lett. 2008. PMID: 18539456

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