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C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage.
Johanssen VA, Johanssen T, Masters CL, Hill AF, Barnham KJ, Collins SJ. Johanssen VA, et al. Among authors: barnham kj. Biochem J. 2014 Apr 1;459(1):103-15. doi: 10.1042/BJ20131378. Biochem J. 2014. PMID: 24438129
The Val-210-Ile pathogenic Creutzfeldt-Jakob disease mutation increases both the helical and aggregation propensities of a sequence corresponding to helix-3 of PrP(C).
Thompson AJ, Barnham KJ, Norton RS, Barrow CJ. Thompson AJ, et al. Among authors: barnham kj. Biochim Biophys Acta. 2001 Jan 12;1544(1-2):242-54. doi: 10.1016/s0167-4838(00)00225-9. Biochim Biophys Acta. 2001. PMID: 11341933
Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.
Jobling MF, Huang X, Stewart LR, Barnham KJ, Curtain C, Volitakis I, Perugini M, White AR, Cherny RA, Masters CL, Barrow CJ, Collins SJ, Bush AI, Cappai R. Jobling MF, et al. Among authors: barnham kj. Biochemistry. 2001 Jul 10;40(27):8073-84. doi: 10.1021/bi0029088. Biochemistry. 2001. PMID: 11434776
Iron inhibits neurotoxicity induced by trace copper and biological reductants.
White AR, Barnham KJ, Huang X, Voltakis I, Beyreuther K, Masters CL, Cherny RA, Bush AI, Cappai R. White AR, et al. Among authors: barnham kj. J Biol Inorg Chem. 2004 Apr;9(3):269-80. doi: 10.1007/s00775-004-0521-8. Epub 2004 Feb 3. J Biol Inorg Chem. 2004. PMID: 14758525
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
Ciccotosto GD, Tew D, Curtain CC, Smith D, Carrington D, Masters CL, Bush AI, Cherny RA, Cappai R, Barnham KJ. Ciccotosto GD, et al. Among authors: barnham kj. J Biol Chem. 2004 Oct 8;279(41):42528-34. doi: 10.1074/jbc.M406465200. Epub 2004 Jul 28. J Biol Chem. 2004. PMID: 15292164
Biological activity and ferric ion binding of fragments of glycine-extended gastrin.
He H, Shehan BP, Barnham KJ, Norton RS, Shulkes A, Baldwin GS. He H, et al. Among authors: barnham kj. Biochemistry. 2004 Sep 21;43(37):11853-61. doi: 10.1021/bi0495984. Biochemistry. 2004. PMID: 15362871
Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.
Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barnham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, Masters CL, Trounce IA. Crouch PJ, et al. Among authors: barnham kj. J Neurosci. 2005 Jan 19;25(3):672-9. doi: 10.1523/JNEUROSCI.4276-04.2005. J Neurosci. 2005. PMID: 15659604 Free PMC article.
Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine.
Ali FE, Leung A, Cherny RA, Mavros C, Barnham KJ, Separovic F, Barrow CJ. Ali FE, et al. Among authors: barnham kj. Free Radic Res. 2006 Jan;40(1):1-9. doi: 10.1080/10715760500329721. Free Radic Res. 2006. PMID: 16298754
Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
Lau TL, Ambroggio EE, Tew DJ, Cappai R, Masters CL, Fidelio GD, Barnham KJ, Separovic F. Lau TL, et al. Among authors: barnham kj. J Mol Biol. 2006 Feb 24;356(3):759-70. doi: 10.1016/j.jmb.2005.11.091. Epub 2005 Dec 20. J Mol Biol. 2006. PMID: 16403524
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.
Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, Lau TL, Tew DJ, Perez K, Wade JD, Bush AI, Drew SC, Separovic F, Masters CL, Cappai R, Barnham KJ. Smith DP, et al. Among authors: barnham kj. J Biol Chem. 2006 Jun 2;281(22):15145-54. doi: 10.1074/jbc.M600417200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595673
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