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18 results
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Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner.
Baptiste-Okoh N, Barsotti AM, Prives C. Baptiste-Okoh N, et al. Among authors: barsotti am. Cell Cycle. 2008 May 1;7(9):1133-8. doi: 10.4161/cc.7.9.5805. Epub 2008 Feb 19. Cell Cycle. 2008. PMID: 18418048
Pro-proliferative FoxM1 is a target of p53-mediated repression.
Barsotti AM, Prives C. Barsotti AM, et al. Oncogene. 2009 Dec 3;28(48):4295-305. doi: 10.1038/onc.2009.282. Epub 2009 Sep 14. Oncogene. 2009. PMID: 19749794 Free PMC article.
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP 4th, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C. Moon SH, et al. Among authors: barsotti am. Cell. 2019 Jan 24;176(3):564-580.e19. doi: 10.1016/j.cell.2018.11.011. Epub 2018 Dec 20. Cell. 2019. PMID: 30580964 Free PMC article.
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Singer S, et al. Among authors: barsotti am. Mol Cell. 2012 Dec 14;48(5):799-810. doi: 10.1016/j.molcel.2012.09.020. Epub 2012 Oct 24. Mol Cell. 2012. PMID: 23102701 Free PMC article.
p53-Dependent induction of PVT1 and miR-1204.
Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ, Prives C. Barsotti AM, et al. J Biol Chem. 2012 Jan 20;287(4):2509-19. doi: 10.1074/jbc.M111.322875. Epub 2011 Nov 22. J Biol Chem. 2012. PMID: 22110125 Free PMC article.
Noncoding RNAs: the missing "linc" in p53-mediated repression.
Barsotti AM, Prives C. Barsotti AM, et al. Cell. 2010 Aug 6;142(3):358-60. doi: 10.1016/j.cell.2010.07.029. Cell. 2010. PMID: 20691894
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
Baptiste-Okoh N, Barsotti AM, Prives C. Baptiste-Okoh N, et al. Among authors: barsotti am. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1937-42. doi: 10.1073/pnas.0711800105. Epub 2008 Jan 31. Proc Natl Acad Sci U S A. 2008. PMID: 18238895 Free PMC article.
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Freed-Pastor WA, et al. Cell. 2012 Jan 20;148(1-2):244-58. doi: 10.1016/j.cell.2011.12.017. Cell. 2012. PMID: 22265415 Free PMC article.
Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.
Barsotti AM, Ryskin M, Zhong W, Zhang WG, Giannakou A, Loreth C, Diesl V, Follettie M, Golas J, Lee M, Nichols T, Fan C, Li G, Dann S, Fantin VR, Arndt K, Verhelle D, Rollins RA. Barsotti AM, et al. Oncotarget. 2015 Feb 20;6(5):2928-38. doi: 10.18632/oncotarget.2758. Oncotarget. 2015. PMID: 25671303 Free PMC article.
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
Barsotti AM, Ryskin M, Rollins RA. Barsotti AM, et al. Epigenomics. 2015 Aug;7(5):687-90. doi: 10.2217/epi.15.27. Epub 2015 Aug 28. Epigenomics. 2015. PMID: 26317265 No abstract available.
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