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Checking on DNA damage in S phase.
Bartek J, Lukas C, Lukas J. Bartek J, et al. Nat Rev Mol Cell Biol. 2004 Oct;5(10):792-804. doi: 10.1038/nrm1493. Nat Rev Mol Cell Biol. 2004. PMID: 15459660 Review.
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.
Chroma K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, Skrott Z, Vrtel R, Bartkova J, Kramara J, Bartek J. Chroma K, et al. Oncogene. 2017 Apr 27;36(17):2405-2422. doi: 10.1038/onc.2016.392. Epub 2016 Nov 14. Oncogene. 2017. PMID: 27841863
IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z. Hubackova S, et al. Oncogene. 2016 Mar 10;35(10):1236-49. doi: 10.1038/onc.2015.162. Epub 2015 May 18. Oncogene. 2016. PMID: 25982278
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response.
Schepeler T, Lamy P, Hvidberg V, Laurberg JR, Fristrup N, Reinert T, Bartkova J, Tropia L, Bartek J, Halazonetis TD, Pan CC, Borre M, Dyrskjøt L, Orntoft TF. Schepeler T, et al. Oncogene. 2013 Aug 1;32(31):3577-86. doi: 10.1038/onc.2012.381. Epub 2012 Aug 27. Oncogene. 2013. PMID: 22926521
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.
Bartkova J, Hamerlik P, Stockhausen MT, Ehrmann J, Hlobilkova A, Laursen H, Kalita O, Kolar Z, Poulsen HS, Broholm H, Lukas J, Bartek J. Bartkova J, et al. Oncogene. 2010 Sep 9;29(36):5095-102. doi: 10.1038/onc.2010.249. Epub 2010 Jun 28. Oncogene. 2010. PMID: 20581868
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer.
Tommiska J, Bartkova J, Heinonen M, Hautala L, Kilpivaara O, Eerola H, Aittomäki K, Hofstetter B, Lukas J, von Smitten K, Blomqvist C, Ristimäki A, Heikkilä P, Bartek J, Nevanlinna H. Tommiska J, et al. Oncogene. 2008 Apr 10;27(17):2501-6. doi: 10.1038/sj.onc.1210885. Epub 2007 Nov 5. Oncogene. 2008. PMID: 17982490
DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.
Bartkova J, Horejsí Z, Sehested M, Nesland JM, Rajpert-De Meyts E, Skakkebaek NE, Stucki M, Jackson S, Lukas J, Bartek J. Bartkova J, et al. Oncogene. 2007 Nov 22;26(53):7414-22. doi: 10.1038/sj.onc.1210553. Epub 2007 Jun 4. Oncogene. 2007. PMID: 17546051
What a 'Ku'incidence!: parallel discoveries of a new DNA repair factor.
Mistrik M, Bartek J. Mistrik M, et al. Cell Death Differ. 2015 Jun;22(6):888-9. doi: 10.1038/cdd.2015.32. Cell Death Differ. 2015. PMID: 25941165 Free PMC article. No abstract available.
Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.
Bartkova J, Moudry P, Hodny Z, Lukas J, Rajpert-De Meyts E, Bartek J. Bartkova J, et al. Int J Androl. 2011 Aug;34(4 Pt 2):e103-13. doi: 10.1111/j.1365-2605.2010.01096.x. Epub 2010 Aug 1. Int J Androl. 2011. PMID: 20695923
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