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(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.
Molenaar P, Savarimuthu SM, Sarsero D, Chen L, Semmler AB, Carle A, Yang I, Bartel S, Vetter D, Beyerdörfer I, Krause EG, Kaumann AJ. Molenaar P, et al. Among authors: bartel s. Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):11-28. doi: 10.1007/s00210-007-0138-x. Epub 2007 Feb 13. Naunyn Schmiedebergs Arch Pharmacol. 2007. PMID: 17295024
Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-protein.
Molenaar P, Bartel S, Cochrane A, Vetter D, Jalali H, Pohlner P, Burrell K, Karczewski P, Krause EG, Kaumann A. Molenaar P, et al. Among authors: bartel s. Circulation. 2000 Oct 10;102(15):1814-21. doi: 10.1161/01.cir.102.15.1814. Circulation. 2000. PMID: 11023937
Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure.
Kaumann A, Bartel S, Molenaar P, Sanders L, Burrell K, Vetter D, Hempel P, Karczewski P, Krause EG. Kaumann A, et al. Among authors: bartel s. Circulation. 1999 Jan 5-12;99(1):65-72. doi: 10.1161/01.cir.99.1.65. Circulation. 1999. PMID: 9884381 Clinical Trial.
213 results