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Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.
Crewe HK, Barter ZE, Yeo KR, Rostami-Hodjegan A. Crewe HK, et al. Among authors: barter ze. Biopharm Drug Dispos. 2011 Sep;32(6):303-18. doi: 10.1002/bdd.760. Epub 2011 Jul 4. Biopharm Drug Dispos. 2011. PMID: 21725985
Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.
Barter ZE, Perrett HF, Yeo KR, Allorge D, Lennard MS, Rostami-Hodjegan A. Barter ZE, et al. Biopharm Drug Dispos. 2010 Nov;31(8-9):516-32. doi: 10.1002/bdd.732. Biopharm Drug Dispos. 2010. PMID: 21104927
Disparity in holoprotein/apoprotein ratios of different standards used for immunoquantification of hepatic cytochrome P450 enzymes.
Perrett HF, Barter ZE, Jones BC, Yamazaki H, Tucker GT, Rostami-Hodjegan A. Perrett HF, et al. Among authors: barter ze. Drug Metab Dispos. 2007 Oct;35(10):1733-6. doi: 10.1124/dmd.107.015743. Epub 2007 Jun 28. Drug Metab Dispos. 2007. PMID: 17600083
Covariation of human microsomal protein per gram of liver with age: absence of influence of operator and sample storage may justify interlaboratory data pooling.
Barter ZE, Chowdry JE, Harlow JR, Snawder JE, Lipscomb JC, Rostami-Hodjegan A. Barter ZE, et al. Drug Metab Dispos. 2008 Dec;36(12):2405-9. doi: 10.1124/dmd.108.021311. Epub 2008 Sep 5. Drug Metab Dispos. 2008. PMID: 18775982
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A. Barter ZE, et al. Curr Drug Metab. 2007 Jan;8(1):33-45. doi: 10.2174/138920007779315053. Curr Drug Metab. 2007. PMID: 17266522 Review.
Age related changes in fractional elimination pathways for drugs: assessing the impact of variable ontogeny on metabolic drug-drug interactions.
Salem F, Johnson TN, Barter ZE, Leeder JS, Rostami-Hodjegan A. Salem F, et al. Among authors: barter ze. J Clin Pharmacol. 2013 Aug;53(8):857-65. doi: 10.1002/jcph.100. Epub 2013 May 30. J Clin Pharmacol. 2013. PMID: 23720017
Response to "Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in Chinese population: opportunities and challenges".
Barter ZE, Tucker GT, Rowland-Yeo K. Barter ZE, et al. Clin Pharmacokinet. 2014 Feb;53(2):203. doi: 10.1007/s40262-013-0118-x. Clin Pharmacokinet. 2014. PMID: 24255012 No abstract available.
Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model.
Cubitt HE, Yeo KR, Howgate EM, Rostami-Hodjegan A, Barter ZE. Cubitt HE, et al. Among authors: barter ze. Xenobiotica. 2011 Aug;41(8):623-38. doi: 10.3109/00498254.2011.560294. Epub 2011 Mar 24. Xenobiotica. 2011. PMID: 21434772
Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based pharmacokinetic modelling.
Barter ZE, Tucker GT, Rowland-Yeo K. Barter ZE, et al. Clin Pharmacokinet. 2013 Dec;52(12):1085-100. doi: 10.1007/s40262-013-0089-y. Clin Pharmacokinet. 2013. PMID: 23818090
Bottom-up modeling and simulation of tacrolimus clearance: prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power.
Ohtani H, Barter Z, Minematsu T, Makuuchi M, Sawada Y, Rostami-Hodjegan A. Ohtani H, et al. Among authors: barter z. Biopharm Drug Dispos. 2011 Dec;32(9):498-506. doi: 10.1002/bdd.777. Epub 2011 Nov 8. Biopharm Drug Dispos. 2011. PMID: 22028295 Clinical Trial.
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