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Molecular architecture of native HIV-1 gp120 trimers.
Liu J, Bartesaghi A, Borgnia MJ, Sapiro G, Subramaniam S. Liu J, et al. Among authors: bartesaghi a. Nature. 2008 Sep 4;455(7209):109-13. doi: 10.1038/nature07159. Epub 2008 Jul 30. Nature. 2008. PMID: 18668044 Free PMC article.
Env is a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120), and forms trimers on the surface of the viral membrane. ...We demonstrate that CD4 binding results in a major reorganization of the Env trimer, causing an o …
Env is a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120), and forms trimers on th …
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.
Sougrat R, Bartesaghi A, Lifson JD, Bennett AE, Bess JW, Zabransky DJ, Subramaniam S. Sougrat R, et al. Among authors: bartesaghi a. PLoS Pathog. 2007 May 4;3(5):e63. doi: 10.1371/journal.ppat.0030063. PLoS Pathog. 2007. PMID: 17480119 Free PMC article.
The trimeric viral envelope glycoprotein surface spikes are heterogeneous in appearance and typically approximately 120 A long and approximately 120 A wide at the distal end. Docking of SIV or HIV-1 on the T cell surface occurs via a neck-shaped contact regio …
The trimeric viral envelope glycoprotein surface spikes are heterogeneous in appearance and typically approximately 120 A long and ap …
Electron tomography of viruses.
Subramaniam S, Bartesaghi A, Liu J, Bennett AE, Sougrat R. Subramaniam S, et al. Among authors: bartesaghi a. Curr Opin Struct Biol. 2007 Oct;17(5):596-602. doi: 10.1016/j.sbi.2007.09.009. Epub 2007 Oct 25. Curr Opin Struct Biol. 2007. PMID: 17964134 Free PMC article. Review.
Understanding the molecular architectures of enveloped and complex viruses is a challenging frontier in structural biology. In these viruses, the structural and compositional variation from one viral particle to another generally precludes the use of either crystallization …
Understanding the molecular architectures of enveloped and complex viruses is a challenging frontier in structural biology. In these …
Classification and 3D averaging with missing wedge correction in biological electron tomography.
Bartesaghi A, Sprechmann P, Liu J, Randall G, Sapiro G, Subramaniam S. Bartesaghi A, et al. J Struct Biol. 2008 Jun;162(3):436-50. doi: 10.1016/j.jsb.2008.02.008. Epub 2008 Mar 21. J Struct Biol. 2008. PMID: 18440828 Free PMC article.
In contrast, electron tomographic approaches have often been used to study the 3D structures of heterogeneous, one-of-a-kind objects such as whole cells where image-averaging strategies are not applicable. ...Modeling the missing data as a multiplying mask in recipr …
In contrast, electron tomographic approaches have often been used to study the 3D structures of heterogeneous, one-of-a-kind objects …
Membrane protein structure determination using cryo-electron tomography and 3D image averaging.
Bartesaghi A, Subramaniam S. Bartesaghi A, et al. Curr Opin Struct Biol. 2009 Aug;19(4):402-7. doi: 10.1016/j.sbi.2009.06.005. Epub 2009 Jul 29. Curr Opin Struct Biol. 2009. PMID: 19646859 Free PMC article. Review.
The vast majority of membrane protein complexes of biological interest cannot be purified to homogeneity, or removed from a physiologically relevant context without loss of function. ...
The vast majority of membrane protein complexes of biological interest cannot be purified to homogeneity, or removed from a physiolog …
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.
White TA, Bartesaghi A, Borgnia MJ, Meyerson JR, de la Cruz MJ, Bess JW, Nandwani R, Hoxie JA, Lifson JD, Milne JL, Subramaniam S. White TA, et al. Among authors: bartesaghi a. PLoS Pathog. 2010 Dec 23;6(12):e1001249. doi: 10.1371/journal.ppat.1001249. PLoS Pathog. 2010. PMID: 21203482 Free PMC article.
Strikingly, in SIV CP-MAC, a CD4-independent strain, trimeric Env is in a constitutively "open" conformation with gp120 trimers splayed out in a conformation similar to that seen for HIV-1 BaL Env when it is complexed with sCD4 and the CD4i antibody 17b. Our …
Strikingly, in SIV CP-MAC, a CD4-independent strain, trimeric Env is in a constitutively "open" conformation with gp120 trimer …
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
Harris A, Borgnia MJ, Shi D, Bartesaghi A, He H, Pejchal R, Kang YK, Depetris R, Marozsan AJ, Sanders RW, Klasse PJ, Milne JL, Wilson IA, Olson WC, Moore JP, Subramaniam S. Harris A, et al. Among authors: bartesaghi a. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11440-5. doi: 10.1073/pnas.1101414108. Epub 2011 Jun 27. Proc Natl Acad Sci U S A. 2011. PMID: 21709254 Free PMC article.
The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120). ...We show that unliganded gp140 trimers a …
The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a het …
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
White TA, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Nandwani R, Hoxie JA, Bess JW, Lifson JD, Milne JL, Subramaniam S. White TA, et al. Among authors: bartesaghi a. J Virol. 2011 Dec;85(23):12114-23. doi: 10.1128/JVI.05297-11. Epub 2011 Sep 21. J Virol. 2011. PMID: 21937655 Free PMC article.
Although binding of gp120 to cell surface CD4 and a chemokine receptor is known to elicit conformational changes in gp120 and gp41, changes in quaternary structure of the trimer have only recently been elucidated. For the HIV-1 BaL isolate, CD4 attachment results in a
Although binding of gp120 to cell surface CD4 and a chemokine receptor is known to elicit conformational changes in gp120 and gp41, c …
Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.
Meyerson JR, White TA, Bliss D, Moran A, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Schauder D, Hartnell LM, Nandwani R, Dawood M, Kim B, Kim JH, Sununu J, Yang L, Bhatia S, Subramaniam C, Hurt DE, Gaudreault L, Subramaniam S. Meyerson JR, et al. Among authors: bartesaghi a. J Vis Exp. 2011 Dec 1;(58):2770. doi: 10.3791/2770. J Vis Exp. 2011. PMID: 22158337 Free PMC article.
This interaction induces a conformational change in the spike, which promotes interaction with a second cell surface co-receptor (5,9). ...This approach is not limited to resolving HIV Envelope structures, and can be extended to other viral membrane proteins and pro …
This interaction induces a conformational change in the spike, which promotes interaction with a second cell surface co-recept …
Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging.
Frank GA, Bartesaghi A, Kuybeda O, Borgnia MJ, White TA, Sapiro G, Subramaniam S. Frank GA, et al. Among authors: bartesaghi a. J Struct Biol. 2012 May;178(2):165-76. doi: 10.1016/j.jsb.2012.01.004. Epub 2012 Jan 10. J Struct Biol. 2012. PMID: 22248450 Free PMC article.
We have previously used cryo-electron tomography combined with sub-volume averaging and classification to obtain 3D structures of macromolecular assemblies in cases where a single dominant species was present, and applied these methods to the analysis of a variety o …
We have previously used cryo-electron tomography combined with sub-volume averaging and classification to obtain 3D structures of macromolec …
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