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A general method for detecting and sizing large plasmids.
Barton BM, Harding GP, Zuccarelli AJ. Barton BM, et al. Anal Biochem. 1995 Apr 10;226(2):235-40. doi: 10.1006/abio.1995.1220. Anal Biochem. 1995. PMID: 7793624
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
Kershaw NJ, McNaughton HJ, Hewitson KS, Hernández H, Griffin J, Hughes C, Greaves P, Barton B, Robinson CV, Schofield CJ. Kershaw NJ, et al. Among authors: barton b. Eur J Biochem. 2002 Apr;269(8):2052-9. doi: 10.1046/j.1432-1033.2002.02853.x. Eur J Biochem. 2002. PMID: 11985581
5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.
Tahlan K, Anders C, Wong A, Mosher RH, Beatty PH, Brumlik MJ, Griffin A, Hughes C, Griffin J, Barton B, Jensen SE. Tahlan K, et al. Among authors: barton b. Chem Biol. 2007 Feb;14(2):131-42. doi: 10.1016/j.chembiol.2006.11.012. Chem Biol. 2007. PMID: 17317567
Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.
Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner G. Smith DJ, et al. Among authors: barton b. EMBO J. 1990 Mar;9(3):741-7. EMBO J. 1990. PMID: 2107074 Free PMC article.
Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.
Jensen SE, Wong A, Griffin A, Barton B. Jensen SE, et al. Among authors: barton b. Antimicrob Agents Chemother. 2004 Feb;48(2):514-20. doi: 10.1128/aac.48.2.514-520.2004. Antimicrob Agents Chemother. 2004. PMID: 14742203 Free PMC article.
Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.
Jensen SE, Paradkar AS, Mosher RH, Anders C, Beatty PH, Brumlik MJ, Griffin A, Barton B. Jensen SE, et al. Among authors: barton b. Antimicrob Agents Chemother. 2004 Jan;48(1):192-202. doi: 10.1128/aac.48.1.192-202.2004. Antimicrob Agents Chemother. 2004. PMID: 14693539 Free PMC article.
Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus.
Mosher RH, Paradkar AS, Anders C, Barton B, Jensen SE. Mosher RH, et al. Among authors: barton b. Antimicrob Agents Chemother. 1999 May;43(5):1215-24. doi: 10.1128/AAC.43.5.1215. Antimicrob Agents Chemother. 1999. PMID: 10223939 Free PMC article.
Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.
Paradkar AS, Mosher RH, Anders C, Griffin A, Griffin J, Hughes C, Greaves P, Barton B, Jensen SE. Paradkar AS, et al. Among authors: barton b. Appl Environ Microbiol. 2001 May;67(5):2292-7. doi: 10.1128/AEM.67.5.2292-2297.2001. Appl Environ Microbiol. 2001. PMID: 11319114 Free PMC article.
Analysis of a commercially improved Penicillium chrysogenum strain series: involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster.
Newbert RW, Barton B, Greaves P, Harper J, Turner G. Newbert RW, et al. Among authors: barton b. J Ind Microbiol Biotechnol. 1997 Jul;19(1):18-27. doi: 10.1038/sj.jim.2900411. J Ind Microbiol Biotechnol. 1997. PMID: 9281849
Intramuscular Corticosteroids for Acute Upper Respiratory Infections Affects Healthcare Utilization.
Parsel SM, Mohammed AE, Fort D, Barton BM, McCoul ED. Parsel SM, et al. Among authors: barton bm. Ann Otol Rhinol Laryngol. 2020 Oct;129(10):988-995. doi: 10.1177/0003489420929717. Epub 2020 May 26. Ann Otol Rhinol Laryngol. 2020. PMID: 32456500
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