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Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.
de Moura Sperotto ND, Deves Roth C, Rodrigues-Junior VS, Ev Neves C, Reisdorfer Paula F, da Silva Dadda A, Bergo P, Freitas de Freitas T, Souza Macchi F, Moura S, Duarte de Souza AP, Campos MM, Valim Bizarro C, Santos DS, Basso LA, Machado P. de Moura Sperotto ND, et al. Among authors: basso la. J Med Chem. 2019 Feb 14;62(3):1231-1245. doi: 10.1021/acs.jmedchem.8b01305. Epub 2019 Jan 17. J Med Chem. 2019. PMID: 30615449
Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution.
de Azevedo WF Jr, Canduri F, dos Santos DM, Silva RG, de Oliveira JS, de Carvalho LP, Basso LA, Mendes MA, Palma MS, Santos DS. de Azevedo WF Jr, et al. Among authors: basso la. Biochem Biophys Res Commun. 2003 Aug 29;308(3):545-52. doi: 10.1016/s0006-291x(03)01431-1. Biochem Biophys Res Commun. 2003. PMID: 12914785
Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.
dos Santos DM, Canduri F, Pereira JH, Vinicius Bertacine Dias M, Silva RG, Mendes MA, Palma MS, Basso LA, de Azevedo WF Jr, Santos DS. dos Santos DM, et al. Among authors: basso la. Biochem Biophys Res Commun. 2003 Aug 29;308(3):553-9. doi: 10.1016/s0006-291x(03)01433-5. Biochem Biophys Res Commun. 2003. PMID: 12914786
Structural basis for inhibition of human PNP by immucillin-H.
Filgueira de Azevedo W Jr, Canduri F, Marangoni dos Santos D, Pereira JH, Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Filgueira de Azevedo W Jr, et al. Among authors: basso la. Biochem Biophys Res Commun. 2003 Oct 3;309(4):917-22. doi: 10.1016/j.bbrc.2003.08.094. Biochem Biophys Res Commun. 2003. PMID: 13679061
188 results