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Paraquat disrupts the anti-inflammatory action of cortisol in human macrophages in vitro: therapeutic implications for paraquat intoxications.
Veríssimo G, Bast A, Weseler AR. Veríssimo G, et al. Among authors: bast a. Toxicol Res (Camb). 2017 Feb 2;6(2):232-241. doi: 10.1039/c6tx00406g. eCollection 2017 Mar 1. Toxicol Res (Camb). 2017. PMID: 30090494 Free PMC article.
However, it is still widely used in Middle/South America and in Asia where it is annually associated with a high incidence of unintentional and intentional poisoning. ...However, a polyphenolic extract of grape seeds consisting of monomeric and oligomeric flavan-3-o …
However, it is still widely used in Middle/South America and in Asia where it is annually associated with a high incidence of uninten …
Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells.
Michels G, Wätjen W, Niering P, Steffan B, Thi QH, Chovolou Y, Kampkötter A, Bast A, Proksch P, Kahl R. Michels G, et al. Among authors: bast a. Toxicology. 2005 Jan 31;206(3):337-48. doi: 10.1016/j.tox.2004.07.022. Toxicology. 2005. PMID: 15588924
In a time course experiment caspase-9 is activated after 6h, while caspase-2 and -3/7 are activated after 12 h. After 24 h, caspase-8/10 also displays activation. We found a concentration-dependent increase in malondialdehyde release suggesting a prooxidative …
In a time course experiment caspase-9 is activated after 6h, while caspase-2 and -3/7 are activated after 12 h. After 24 h, caspase-8 …
Antibiotics exposure and health risks: chloramphenicol.
Hanekamp JC, Bast A. Hanekamp JC, et al. Among authors: bast a. Environ Toxicol Pharmacol. 2015 Jan;39(1):213-20. doi: 10.1016/j.etap.2014.11.016. Epub 2014 Dec 4. Environ Toxicol Pharmacol. 2015. PMID: 25528412 Review.
Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific data hampers setting of an Acceptable Daily Intake (ADI). Consequently, a maximum residue limit (MRL) in food could not be establishe …
Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific …
Peroxynitrite scavenging of flavonoids: structure activity relationship.
Heijnen CG, Haenen GR, Vekemans JA, Bast A. Heijnen CG, et al. Among authors: bast a. Environ Toxicol Pharmacol. 2001 Sep;10(4):199-206. doi: 10.1016/s1382-6689(01)00083-7. Environ Toxicol Pharmacol. 2001. PMID: 21782577
A good correlation was found between the peroxynitrite scavenging activity of the substituted phenols and the Hammett σ or the E(HOMO). Flavonols containing a catechol group (3'- and 4'-OH) in ring B (rutin and monohydroxyethyl rutoside) or an AC-ring with three OH
A good correlation was found between the peroxynitrite scavenging activity of the substituted phenols and the Hammett σ or the E(HOMO
Protection against chemotaxis in the anti-inflammatory effect of bioactives from tomato ketchup.
Hazewindus M, Haenen GR, Weseler AR, Bast A. Hazewindus M, et al. Among authors: bast a. PLoS One. 2014 Dec 31;9(12):e114387. doi: 10.1371/journal.pone.0114387. eCollection 2014. PLoS One. 2014. PMID: 25551565 Free PMC article.
Chemotaxis was effectively impeded as demonstrated by a reduced monocyte migration. This effect correlated with the reduction of IL-8 production in the presence of the test compounds and extracts. ...Such a pleotropic mode of action exemplifies its potential mitigat …
Chemotaxis was effectively impeded as demonstrated by a reduced monocyte migration. This effect correlated with the reduction of IL-8 …
Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep.
Bieghs V, Vlassaks E, Custers A, van Gorp PJ, Gijbels MJ, Bast A, Bekers O, Zimmermann LJ, Lütjohann D, Voncken JW, Gavilanes AW, Kramer BW, Shiri-Sverdlov R. Bieghs V, et al. Among authors: bast a. Pediatr Res. 2010 Dec;68(6):466-72. doi: 10.1203/PDR.0b013e3181f70eeb. Pediatr Res. 2010. PMID: 20717072
Chorioamnionitis frequently induces a fetal inflammatory response syndrome (FIRS), characterized by an elevation of proinflammatory mediators and systemic inflammation. ...
Chorioamnionitis frequently induces a fetal inflammatory response syndrome (FIRS), characterized by an elevation of proinflammatory m …
Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms.
Ruijters EJ, Haenen GR, Willemsen M, Weseler AR, Bast A. Ruijters EJ, et al. Among authors: bast a. Int J Mol Sci. 2016 Feb 15;17(2):239. doi: 10.3390/ijms17020239. Int J Mol Sci. 2016. PMID: 26891295 Free PMC article.
In this exploratory study we screened a broad range of food-derived bioactives for their antioxidant and anti-inflammatory effects in order to investigate whether their antioxidant effects are associated with the ability to preserve the anti-inflammatory effects of cortiso …
In this exploratory study we screened a broad range of food-derived bioactives for their antioxidant and anti-inflammatory effects in …
The cocoa flavanol (-)-epicatechin protects the cortisol response.
Ruijters EJ, Haenen GR, Weseler AR, Bast A. Ruijters EJ, et al. Among authors: bast a. Pharmacol Res. 2014 Jan;79:28-33. doi: 10.1016/j.phrs.2013.11.004. Epub 2013 Nov 20. Pharmacol Res. 2014. PMID: 24269961
The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stress and consequential GC resistance and provides a fundament for the rational use of dietary antioxidants....
The observed effect of the cocoa flavanol EC will especially be of relevance in pathophysiological conditions with increased oxidative stres …
Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health--a randomized controlled clinical pilot study.
Weseler AR, Ruijters EJ, Drittij-Reijnders MJ, Reesink KD, Haenen GR, Bast A. Weseler AR, et al. Among authors: bast a. PLoS One. 2011;6(12):e28460. doi: 10.1371/journal.pone.0028460. Epub 2011 Dec 8. PLoS One. 2011. PMID: 22174811 Free PMC article. Clinical Trial.
BACKGROUND: Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep desire for healthy ageing. ...However, integrating all measured effects into a global, so-called vascular health index revealed a
BACKGROUND: Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep des …
Dietary supplement intake during pregnancy; better safe than sorry?
de Boer A, Bast A, Godschalk R. de Boer A, et al. Among authors: bast a. Regul Toxicol Pharmacol. 2018 Jun;95:442-447. doi: 10.1016/j.yrtph.2018.03.014. Epub 2018 Mar 20. Regul Toxicol Pharmacol. 2018. PMID: 29567330
We therefore call for both conducting research in birth cohorts and animal studies to identify potential health effects in progeny of supplement consuming mothers as well as the establishment of a nutrivigilance scheme to identify favorable and adverse effects post-marketi …
We therefore call for both conducting research in birth cohorts and animal studies to identify potential health effects in progeny of supple …
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