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The pharmacology of the antioxidant lipoic acid.
Biewenga GP, Haenen GR, Bast A. Biewenga GP, et al. Gen Pharmacol. 1997 Sep;29(3):315-31. doi: 10.1016/s0306-3623(96)00474-0. Gen Pharmacol. 1997. PMID: 9378235 Review.
Antioxidant activity is a relative concept: it depends on the kind of oxidative stress and the kind of oxidizable substrate (e.g., DNA, lipid, protein). 3. ...As a metal chelator, lipoic acid was shown to provide antioxidant activity by chelating Fe2+ and Cu2+; DHLA …
Antioxidant activity is a relative concept: it depends on the kind of oxidative stress and the kind of oxidizable substrate (e.g., DN …
Inhibition of rat hepatic microsomal lipid peroxidation by mesna via glutathione.
Bast A, Haenen GR, Savenije-Chapel EM. Bast A, et al. Arzneimittelforschung. 1987 Sep;37(9):1043-5. Arzneimittelforschung. 1987. PMID: 3124863
The inhibition by GSH seems specific since the sulfhydryl agent sodium 2-mercaptoethanesulfonate (mesna) gave a slight stimulation of lipid peroxidation. This stimulation is probably explained by a reduction by mesna of dehydroascorbic acid which is formed during th …
The inhibition by GSH seems specific since the sulfhydryl agent sodium 2-mercaptoethanesulfonate (mesna) gave a slight stimulation of …
Effect of thiols on lipid peroxidation in rat liver microsomes.
Haenen GR, Vermeulen NP, Timmerman H, Bast A. Haenen GR, et al. Chem Biol Interact. 1989;71(2-3):201-12. doi: 10.1016/0009-2797(89)90035-5. Chem Biol Interact. 1989. PMID: 2598297
Cysteamine afforded a pronounced protection against in vitro lipid peroxidation. In contrast to the labile character of the glutathione dependent protection, the protection by cysteamine was not affected by heat-pretreatment of the liver microsomes or alkylating protein su …
Cysteamine afforded a pronounced protection against in vitro lipid peroxidation. In contrast to the labile character of the glutathio …
Molecular pharmacological aspects of antiarrhythmic activity. I. Class I and class III compounds and lipid peroxidation.
Rekka E, Mannhold RM, Bast A, Timmerman H. Rekka E, et al. Biochem Pharmacol. 1990 Jan 1;39(1):95-100. doi: 10.1016/0006-2952(90)90652-2. Biochem Pharmacol. 1990. PMID: 2297363
There is a trend toward a parabolic relationship between antioxidant potency and lipophilicity. Three of the tested antiarrhythmics, namely the lipophilic amiodarone, aprindine and asocainol, were very potent antioxidants, and a further investigation of conce …
There is a trend toward a parabolic relationship between antioxidant potency and lipophilicity. Three of the tested antiarrhyt …
The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant.
Aarts L, van der Hee R, Dekker I, de Jong J, Langemeijer H, Bast A. Aarts L, et al. FEBS Lett. 1995 Jan 2;357(1):83-5. doi: 10.1016/0014-5793(94)01337-z. FEBS Lett. 1995. PMID: 8001686
The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to alpha-tocopherol, since it also contains a phenolic OH-group. ...These results suggest that propofol acts similarly to alpha-tocopherol as a chain breaking anti …
The anesthetic agent propofol (2,6-diisopropylphenol) has a chemical structure which is similar to alpha-tocopherol, since it also co …
Molecular pharmacology of vitamin E: structural aspects of antioxidant activity.
van Acker SA, Koymans LM, Bast A. van Acker SA, et al. Free Radic Biol Med. 1993 Sep;15(3):311-28. doi: 10.1016/0891-5849(93)90078-9. Free Radic Biol Med. 1993. PMID: 8406131 Review.
A molecular explanation for the antioxidant activity often is based on molecular parameters, such as Hammett sigma and Brown sigma +. ...
A molecular explanation for the antioxidant activity often is based on molecular parameters, such as Hammett sigma and Brown sigma +.
Progressively motile human spermatozoa are well protected against in vitro lipid peroxidation imposed by induced oxidative stress.
Rhemrev JP, Vermeiden JP, Haenen GR, De Bruijne JJ, Rekers-Mombarg LT, Bast A. Rhemrev JP, et al. Andrologia. 2001 May;33(3):151-8. doi: 10.1046/j.1439-0272.2001.00430.x. Andrologia. 2001. PMID: 11380330
These 24 samples appeared to show a large variation in motility percentages and numbers. Spermatozoa of these semen samples were isolated from the seminal plasma and exposed to induced radical oxygen stress imposed by iron/ascorbate. ...
These 24 samples appeared to show a large variation in motility percentages and numbers. Spermatozoa of these semen samples were isol …
Frequency-dependent autoinhibition of histamine release from rat cortical slices: a possible role for H3 receptor reserve.
Van der Vliet A, Van der Werf JF, Bast A, Timmerman H. Van der Vliet A, et al. J Pharm Pharmacol. 1988 Aug;40(8):577-9. doi: 10.1111/j.2042-7158.1988.tb05308.x. J Pharm Pharmacol. 1988. PMID: 2466977
The pA2 value of the H3 antagonist impromidine was, however, not altered at different stimulation frequencies; for a partial agonist only the maximal effect was influenced. These results indicate the existence of a receptor reserve at the H3 autoreceptor....
The pA2 value of the H3 antagonist impromidine was, however, not altered at different stimulation frequencies; for a partial agonist …
Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain.
Jansen FP, Wu TS, Voss HP, Steinbusch HW, Vollinga RC, Rademaker B, Bast A, Timmerman H. Jansen FP, et al. Br J Pharmacol. 1994 Oct;113(2):355-62. doi: 10.1111/j.1476-5381.1994.tb16995.x. Br J Pharmacol. 1994. PMID: 7834183 Free PMC article.
The binding of the first selective radiolabelled histamine H3-receptor antagonist [125I]-iodophenpropit to rat cerebral cortex membranes was characterized. 2. [125I]-iodophenpropit, radiolabelled to a high specific activity of 1900 Ci mmol-1, saturably bound to a si …
The binding of the first selective radiolabelled histamine H3-receptor antagonist [125I]-iodophenpropit to rat cerebral cortex membranes was …
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